manganese;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid | 6485-39-8

• 物质功能分类: 食品添加剂 - 营养强化剂 - 无机盐类
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: manganese;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
• CAS: 6485-39-8
• 化学式: C₁₂H₂₄MnO₁₄
• 分子量: 447.25
• InChiKey: MFRCYNUFJYLVKK-IYEMJOQQSA-N

物化性质

• 闪点：
  100.0
• 溶解度：
  易溶于水，几乎不溶于无水乙醇，不溶于二氯甲烷。
• LogP：
  -3.175 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.99
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  277
• 氢给体数：
  12
• 氢受体数：
  14

ADMET

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要进行治疗……。监测休克，如有必要进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的咳嗽反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。/锰及其相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Manganese and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于失去意识或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。监测心率和必要时治疗心律失常... . 开通静脉通道，使用5%葡萄糖盐水/生理盐水维持静脉通路："保持开放"，最低流量/。如果出现低血容量的迹象，使用乳酸钠林格液。考虑使用药物治疗肺水肿... . 对于伴有低血容量迹象的低血压，谨慎给予液体。如果液体量正常但仍有低血压，考虑使用血管加压药。注意液体过载的迹象... . 使用丙美卡因盐酸协助眼部冲洗... . /锰及其相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Manganese and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 帕金森病

Neurotoxin - Parkinsonism

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，并在必要时进行治疗……。监测休克，并在必要时进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽，有强烈的咳嗽反射，并且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。/锰及其相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Manganese and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于失去意识或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。监测心率和必要时治疗心律失常... . 开通静脉通道，使用5%葡萄糖盐水/生理盐水维持静脉通路："保持开放"，最低流量/。如果出现低血容量的迹象，使用乳酸钠林格液。考虑使用药物治疗肺水肿... . 对于伴有低血容量迹象的低血压，谨慎给予液体。如果液体量正常但仍然存在低血压，考虑使用血管加压药。注意观察液体过载的迹象... . 使用丙美卡因氢氯化物辅助眼部冲洗... . /锰及其相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Manganese and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2918160000
• 危险性防范说明：
  P264,P280,P305+P351+P338,P337+P313
• 危险性描述：
  H319
• 储存条件：
  库房应保持低温、通风和干燥的环境。

SDS

---

Section 1. Chemical Product and Company Identification
Manganese gluconate
Common Name/
Trade Name
Manganese gluconate

---

Section 4. First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
Eye Contact
15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Skin Contact
Cold water may be used.
Serious Skin Contact Not available.
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
Inhalation
medical attention.
Not available.
Serious Inhalation
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
Ingestion
unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms
appear.
Not available.
Serious Ingestion

---

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2). Some metallic oxides.
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Non-flammable in presence of shocks.
Various Substances
Slightly explosive in presence of open flames and sparks.
Explosion Hazards in
Non-explosive in presence of shocks.
Presence of Various
Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
As with most organic solids, fire is possible at elevated temperatures
Special Remarks on
Fire Hazards
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
Special Remarks on
explosion hazard.
Explosion Hazards

---

Section 6. Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
Small Spill
water on the contaminated surface and dispose of according to local and regional authority requirements.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on
Large Spill
the contaminated surface and allow to evacuate through the sanitary system. Be careful that the product is not
present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.
Manganese gluconate

---

Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label.
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Storage

---

Section 8. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering Controls
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
of a Large Spill
handling this product.
Exposure Limits TWA: 5 (mg(Mn)/m3) from ACGIH (TLV) [United States] Inhalation (as Mn, Dust and Compounds)
TWA: 1 STEL: 3 (mg(Mn)/m3) from ACGIH (TLV) [United States] Inhalation(as Mn, Fume)
Consult local authorities for acceptable exposure limits.

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Section 9. Physical and Chemical Properties
Solid. (Powdered solid.) Not available.
Physical state and O dor
appearance
Not available.
Taste
445.23 g/mole
Molecular Weight
White to very light pink (Light.)
Color
Not available.
pH (1% soln/water)
Not available.
Boiling Point
Not available.
Melting Point
Not available.
Critical Temperature
Not available.
Specific Gravity
Not applicable.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
Not available.
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
See solubility in water.
Dispersion Properties
Easily soluble in cold water.
Solubility
Insoluble in alcohol, benzene.
Manganese gluconate

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Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Conditions of Instability Excess heat, incompatible materials
Incompatibility with various Not available.
substances
Non-corrosive in presence of glass.
Corrosivity
No information found at this time.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
Will not occur.
Polymerization

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Section 11. Toxicological Information
Inhalation. Ingestion.
Routes of Entry
Toxicity to Animals Acute oral toxicity (LD50): 5850 mg/kg [Rat].
Chronic Effects on Humans Not available.
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Other Toxic Effects on
Humans
Not available.
Special Remarks on
Toxicity to Animals
Not available.
Special Remarks on
Chronic Effects on Humans
Acute Potential Health Effects:
Special Remarks on other
Skin: May cause skin irritation.
Toxic Effects on Humans
Eyes: Dust may cause eye irritation.
Inhalation: Dust may cause respiratory tract irritation.
Ingestion: Ingestion of small amounts during normal handling is not likely to be harmful.

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Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The product itself and its products of degradation are not toxic.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
Manganese gluconate

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Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental control
Waste Disposal
regulations.

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Section 14. Transport Information
Not a DOT controlled material (United States).
DO T Cl assi fi cati on
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DO T (Pi ctograms)

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Section 15. Other Regulatory Information and Pictograms
FDA: Direct Food Additives GRAS list (21CFR 184.1452). This CFR section should always be consulted for the
Federal and State
complete context before any conclusion is made as to the allowed regulated use.
Regulations
FDA: Everything Added to Food in the United States (EAFUS) list (21 CFR: 184.1452, and 582.80). These CFR
sections should always be consulted for the complete context before any conclusion is made as to the allowed
regulated use.
California prop. 65: This product contains the following ingredients for which the State of California has found to
California
cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: No products were found.
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
Other Regulations
229-350-4).
Canada: Listed on Canadian Domestic Substance List (DSL).
China: Not listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Not listed on National Inventory (KECI).
Philippines: Not listed on National Inventory (PICCS).
Australia: Listed on AICS.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC) This product is not classified according Not applicable.
to the EU regulations.
Health Hazard
HMIS (U.S.A.) 1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
Manganese gluconate
DSCL (Europe)
(Pictograms)
TDG(Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or equivalent.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途

葡萄糖酸锰主要用作营养品和膳食添加剂，有助于预防皮肤炎、关节痛等疾病。

作用

葡萄糖酸锰可以激活身体的酶，从而促进新陈代谢能力，支持身体生长。此外，它对骨骼发育也有积极作用。我们知道锰是人体必需的微量元素，其缺乏会导致生长缓慢，并影响生殖功能。除此之外，葡萄糖酸锰还可以用作营养强化剂，帮助消除疲劳和改善消化等。

适用范围

锰可以激活大量酶并参与人体代谢活动，促进正常生长与成骨。缺乏锰会引发生长迟缓及生殖功能障碍。它是一种很好的食物强化剂。根据GB2760-1996标准，在乳制品中的用量为1.08～4.32毫克/千克；在婴儿配方食品中剂量则为1.32～5.26毫克/千克。

含量分析

精确称取约600mg试样，放入250ml瓷皿中，加入水溶解。然后加盐酸羟胺1g、氨一氯化铵缓冲液(TS-12)10ml和羊毛铬黑试液(TS-97)5滴后，用0.05mol/L的EDTA二钠滴定至深蓝色。每毫升0.05mol/L的EDTA二钠相当于葡萄糖酸锰(C12H22MnO14·2H2O)24.06mg。

毒性

GRAS(FDA，§182．5452，2000)。

使用限量

• FDA，§184．1452(2000)：适用于焙烤制品、无醇饮料、乳制品、鱼制品、肉制品、禽制品以及婴儿配方食品等，以GMP为限。
• GB 2760—1996(mg/kg)：在乳制品中的用量为1.08～4.32；在婴幼儿配方食品中剂量则为1.32～5.26。

化学性质

葡萄糖酸锰是一种浅粉红色粉末，极易溶于热水，极难溶于乙醇。

用途

• 营养增补剂（作为锰强化剂）。
• 葡萄糖酸锰用作营养强化剂，我国规定可用于婴幼儿配方食品，使用量为1.32～5.26mg/kg(以锰计)；在乳制品中为1.08～4.32mg/kg。
• 可用于增强食物中的营养价值。

用途

锰可激活大量酶并参与机体代谢活动，促进人体生长和正常的成骨作用。缺乏时会导致生长迟缓及生殖功能障碍，是一种良好的食品强化剂。

生产方法

限于酶法生产的产品：葡萄糖经黑曲霉菌转化为葡萄糖酸内酯，再与硫酸锰反应制得成品。

生产方法

由葡萄糖酸与氢氧化锰反应而得。

类别

有毒物质。

可燃性危险特性

可燃，在火场排出含锰辛辣刺激烟雾。

储运特性

库房低温、通风、干燥。

灭火剂

水、二氧化碳、干粉、泡沫。