3-(2-甲氧乙氧基)溴丙烷 | 59551-75-6

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 烃类卤化物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-(2-甲氧乙氧基)溴丙烷
• 中文别名: 3-(2-甲氧基乙氧基)丙酰溴；乙二醇-3-溴丙基甲醚；1-溴-3-(2-甲氧基乙氧基)丙烷
• 英文名称: 1-bromo-3-(2-methoxyethoxy)propane
• 英文别名: 3-(2-methoxyethoxy)propyl bromide
• CAS: 59551-75-6
• 化学式: C₆H₁₃BrO₂
• 分子量: 197.072
• InChiKey: XXRSNYDVVFLAPC-UHFFFAOYSA-N

物化性质

• 稳定性/保质期：
  避免直接接触水和氧化物。

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  3
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2909199090

SDS

3-(2-Methoxyethoxy)propyl Bromide
SAFETY DATA SHEET

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Section 1. IDENTIFICATION OF THE SUBSTANCE OR MIXTURE AND OF THE SUPPLIER
Product name: 3-(2-Methoxyethoxy)propyl Bromide

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Section 2. HAZARDS IDENTIFICATION
Classification of the GHS
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS Not classified
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements
None
Pictograms or hazard symbols
Signal word Warning
Combustible liquid
Hazard statement
Precautionary statements
Keep away from flames and hot surfaces.
[Prevention]
Wear protective gloves and eye/face protection.
Store in a well-ventilated place. Keep cool.
[Storage]
[Disposal] Dispose of contents/container through a waste management company authorized by
the local government

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Component(s): 3-(2-Methoxyethoxy)propyl Bromide
Percent: >95.0%(GC)
CAS Number: 59551-75-6
1-Bromo-3-(2-methoxyethoxy)propane , Ethylene Glycol 3-Bromopropyl Methyl Ether
Synonyms:
Chemical Formula: C6H13BrO2

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Get medical advice/attention if you feel unwell. Rinse mouth.
Ingestion:
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
3-(2-Methoxyethoxy)propyl Bromide

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Section 5. FIRE-FIGHTING MEASURES
Specific hazards: Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
Specific methods: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in a suitable absorbent (e.g. rag, dry sand, earth, saw-dust).
containment and cleaning In case of large amount of spillage, contain a spill by bunding. Adhered or collected
up: material should be promptly disposed of, in accordance with appropriate laws and
regulations.
Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
hazards: case of a fire. Use spark-proof tools and explosion-proof equipment.

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Section 7. HANDLING AND STORAGE
Handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapor or mist. Keep away from flames and hot surfaces. Take
measures to prevent the build up of electrostatic charge. Use explosion-proof
equipment. Wash hands and face thoroughly after handling.
Use a closed system, ventilation.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Storage
Storage conditions: Keep container tightly closed. Store in a refrigerator.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Law is followed.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: clear
Color: Colorless - Slightly pale yellow
Odor: No data available
pH: No data available
Melting point/freezing point:No data available
Boiling Point/Range: No data available
Flash Point: No data available
Explosive limits
Lower: No data available
Upper: No data available
Density: No data available
3-(2-Methoxyethoxy)propyl Bromide

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Solubility: No data available

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Section 10. STABILITY AND REACTIVITY
Stability: Stable under proper conditions.
Reactivity: No special reactivity has been reported.
Conditions to avoid: Heat-sensitive
Incompartible materials: oxidizing agents
Hazardous Decomposition Carbon monoxide, Carbon dioxide, Hydrogen bromide
Products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
No data available
NTP =
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
Crustacea: No data available
Algae: No data available
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobillity in soil
log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not Listed

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26,
2002): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were
prescribed.
3-(2-Methoxyethoxy)propyl Bromide

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-(2-甲氧乙氧基)溴丙烷 在 18-冠醚-6 、 乙酸酐 、 potassium carbonate 、 溶剂黄146 、 三乙胺 、 magnesium chloride 作用下， 以 乙醇 、 水 、 丙酮 、 乙腈 为溶剂， 反应 7.0h， 生成 7-fluoro-8-(3-(2-methoxyethoxy)propoxy)-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione
  参考文献：
  名称：

  METHODS OF TREATING CANCER WITH SMALL MOLECULE NF-kB INHIBITORS

  摘要：

  本发明提供了一种能够抑制NF-κB的化合物，还提供了含有这些化合物的药物组合物以及使用这些化合物的方法。此外，还提供了用于治疗癌症和实体肿瘤的方法和试剂盒，以及利用本文描述的NF-κB抑制剂诱导癌细胞死亡和凋亡的方法和试剂盒。

  公开号：

  US20190000851A1
• 作为产物：
  描述：

  3-(2-甲氧基乙氧基)-1-丙烯 在 硼烷 、 溴 、 sodium methylate 作用下， 生成 3-(2-甲氧乙氧基)溴丙烷
  参考文献：
  名称：

  水溶性氢化锡试剂

  摘要：

  已经合成了带有三个甲氧基乙氧基丙基的水溶性氢化锡。它可以还原水或有机溶剂中的各种烷基卤。

  DOI：

  10.1016/s0040-4039(00)88997-2

文献信息

• FLUORENE-TYPE COMPOUND, PHOTOPOLYMERIZATION INITIATOR COMPRISING SAID FLUORENE-TYPE COMPOUND, AND PHOTOSENSITIVE COMPOSITION CONTAINING SAID PHOTOPOLYMERIZATION INITIATOR
  申请人：Daito Chemix Corporation

  公开号：US20150259321A1

  公开（公告）日：2015-09-17

  According to an embodiment of the present invention, there is provided a novel fluorene-based compound and a photopolymerization initiator using the fluorene-based compound. The fluorene-based compound according to an embodiment of the present invention is represented by the general formula (1). A photopolymerization initiator having additionally high sensitivity can be provided by using the fluorene-based compound. In addition, a photopolymerization initiator that can impart additionally excellent characteristics can be provided by appropriately selecting, for example, a substituent.

  根据本发明实施例，提供了一种新的基于芴的化合物和使用该基于芴的化合物的光聚合引发剂。根据本发明实施例，基于芴的化合物由通式（1）表示。通过使用基于芴的化合物，可以提供具有更高灵敏度的光聚合引发剂。此外，通过适当选择例如取代基，可以提供具有额外优异特性的光聚合引发剂。
• Approaches to new water-soluble phosphines
  作者：Terence N. Mitchell、Kerstin Heesche-Wagner

  DOI：10.1016/0022-328x(92)85025-r

  日期：1992.9

  Approaches to water-soluble phosphines are described which involve conversion of ethylene glycol derivatives and sugar diacetonides into monoallyl ethers, and hydrophosphorylation of the latter. In the case of the sugars, water-solubility is conferred by a subsequent hydrolysis.

  描述了水溶性膦的方法，该方法涉及将乙二醇衍生物和糖二丙酮化物转化为单烯丙基醚，以及后者的磷酸化。在糖的情况下，通过随后的水解赋予水溶性。
• Inhibitors of checkpoint kinases (Wee1 and Chk1)
  申请人：Booth John Richard

  公开号：US20050250836A1

  公开（公告）日：2005-11-10

  This invention relates to substituted indacene molecules that specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1 and are useful in the treatment of proliferative disorders.

  这项发明涉及替代的吲哚烯分子，特异性地抑制检查点激酶Wee1和Chk1中的一个或两个，并在治疗增殖性疾病中有用。
• FUSED INDAZOLE PYRIDONE COMPOUNDS AS ANTIVIRALS
  申请人：Novartis AG

  公开号：US20180312507A1

  公开（公告）日：2018-11-01

  The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

  这项发明提供了如下所述的化合物的化学式(I)，以及药用盐、含有这些化合物的药物组合物，以及使用这些化合物、盐和组合物治疗病毒感染，特别是由乙型肝炎病毒引起的感染，并减少与HBV相关的严重病情发生的方法。
• Fused ring compound and use thereof
  申请人：Suzuki Hideo

  公开号：US20100190747A1

  公开（公告）日：2010-07-29

  The present invention provides a compound represented by the formula: wherein the symbols are as described in the specification, or a salt thereof, which is useful for preventing/treating eicosanoid-associated diseases such as atherosclerosis, diabetes, obesity, atherothrombosis, asthma, fever, pain, cancer, rheumatism, osteoarthritis and atopic dermatitis, and which has an excellent pharmacological action, physicochemical properties, etc.

  本发明提供一种化合物，其化学式如下： 其中符号如规范中所述，或其盐，用于预防/治疗与前列腺素相关的疾病，如动脉粥样硬化、糖尿病、肥胖、动脉血栓形成、哮喘、发热、疼痛、癌症、风湿病、骨关节炎和特应性皮炎等，并具有优异的药理作用、理化性质等。

表征谱图