DL-重酒石酸胆碱 | 14307-43-8

• 物质功能分类: 有机原料 - 有机金属盐
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: DL-重酒石酸胆碱
• 英文名称: diammonium tartate
• 英文别名: L-(+)-tartaric acid ammonium salt；ammonium L-(+)-tartrate；ammonium tartrate；L_g-tartaric acid ; diammonium-L_g-tartrate；L_g-Weinsaeure; Diammonium-L_g-tartrat；L_g-Weinsaeure; Diammoniumtartrat；Ammonium hydrogen l-tartrate；azanium;(2R,3R)-2,3,4-trihydroxy-4-oxobutanoate
• CAS: 14307-43-8；3164-29-2
• 化学式: C₄H₆O₆*2H₃N
• 分子量: 184.149
• InChiKey: ZMFVLYPTTFPBNG-ZVGUSBNCSA-N

物化性质

• 物理描述：
  Ammonium tartrate is a white crystalline solid. It is soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used to manufacture fabrics and in medicine.
• 密度：
  1.6 at 77 °F (USCG, 1999)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.96
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  116
• 氢给体数：
  5
• 氢受体数：
  7

制备方法与用途

用途：用作分析试剂，也广泛应用于制药工业。

反应信息

• 作为反应物：
  描述：

  DL-重酒石酸胆碱 在 硫酸 作用下， 以 丙酮 为溶剂， 生成 L-酒石酸
  参考文献：
  名称：

  一种D-乙酯生产中回收和套用L-(+)-酒石酸的 方法

  摘要：

  本发明公开了一种D‑乙酯生产中回收和套用L‑(+)‑酒石酸的方法，包括如下步骤：1）、L‑乙酯母液回收L‑(+)‑酒石酸钙晶体；2）、D‑乙酯母液回收L‑(+)‑酒石酸双盐水溶液；3）、L‑(+)‑酒石酸双盐酸化；4）、L‑(+)‑酒石酸单盐酸化回收L‑(+)‑酒石酸；5）、减压浓缩、结晶、分离、干燥等处理。本发明采用惰性有机溶剂取代常规水相法回收L‑(+)‑酒石酸，避免了发生副反应的几率，所得产品的纯度和比旋光度均可达到原料质量标准，可直接循环用于D‑乙酯的手性拆分。本发明对D‑乙酯生产过程中的两种组分不同的母液釆取不同的回收处理工艺，显著提高了产品的品质，整个回收条件温和，操作较简单，易于控制。

  公开号：

  CN104355990B
• 作为产物：
  描述：

  L-(+)-酒石酸二乙酯 在 ammonium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 生成 DL-重酒石酸胆碱
  参考文献：
  名称：

  一种D-乙酯生产中回收和套用L-(+)-酒石酸的 方法

  摘要：

  本发明公开了一种D‑乙酯生产中回收和套用L‑(+)‑酒石酸的方法，包括如下步骤：1）、L‑乙酯母液回收L‑(+)‑酒石酸钙晶体；2）、D‑乙酯母液回收L‑(+)‑酒石酸双盐水溶液；3）、L‑(+)‑酒石酸双盐酸化；4）、L‑(+)‑酒石酸单盐酸化回收L‑(+)‑酒石酸；5）、减压浓缩、结晶、分离、干燥等处理。本发明采用惰性有机溶剂取代常规水相法回收L‑(+)‑酒石酸，避免了发生副反应的几率，所得产品的纯度和比旋光度均可达到原料质量标准，可直接循环用于D‑乙酯的手性拆分。本发明对D‑乙酯生产过程中的两种组分不同的母液釆取不同的回收处理工艺，显著提高了产品的品质，整个回收条件温和，操作较简单，易于控制。

  公开号：

  CN104355990B
• 作为试剂：
  描述：

  2-碘苯甲醛 、 3',5'-di-O-acetyl-3-buta-2,3-dien-1-ylthymidine 在 tris-(dibenzylideneacetone)dipalladium(0) 、 三(2-呋喃基)膦 、 potassium carbonate 、 DL-重酒石酸胆碱 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以50%的产率得到3',5'-di-O-acetyl-3-[2-(6-bromoisoquinolin-4-yl)ethyl]thymidine
  参考文献：
  名称：

  简便的钯催化的三组分级联途径合成功能化的异喹啉酮和异喹啉

  摘要：

  钯催化的三组分级联过程，涉及将2-碘代苯甲酸酯，-苯甲醛或苯乙酮与取代的丙二烯和酒石酸铵作为铵替代物的偶联，提供了一种新颖且简便的方法以...

  DOI：

  10.1039/c5cc07526b

文献信息

• Process for synthesis of D1 receptor antagonists
  申请人：Schering Corporation

  公开号：US20030199690A1

  公开（公告）日：2003-10-23

  In one embodiment, the present invention describes the synthesis of a compound of formula 1 and intermediates therefor.

  在一种实施方式中，本发明描述了化合物formula1的合成及其中间体。
• Solvent-Free Synthesis of Tartramides Under Microwave Activation
  作者：R. Plantier-Royon、C. Portella、F. Massicot、D. Saleur、A. Sudha

  DOI：10.1055/s-2001-18724

  日期：——

  The preparation of aliphatic, aromatic or functionalized tartramides directly from tartaric acid and amines under microwave activation is described. The inexpensive, solvent free and fast reaction conditions are the important features of the procedure.

  描述了在微波激活下直接从酒石酸和胺制备脂肪族、芳香族或功能化酒石酰胺的方法。这种方法的主要特点是反应条件廉价、无溶剂且迅速。
• シス−１−アミノ−４−ヒドロキシメチル−２−シクロペンテンまたはその塩の製造方法
  申请人：株式会社クラレ

  公开号：JP2005298405A

  公开（公告）日：2005-10-27

  PROBLEM TO BE SOLVED: To provide a method capable of producing cis-1-amino-4-hydroxymethyl-2-cyclopentene or its salt with high selectivity and a high yield by using inexpensive reactants easily handleable.

  SOLUTION: Cis-1-amino-4-hydroxymethyl-2-cyclopentene represented by formula (II) or its salt is produced by mixing a cis-4-amino-2-cyclopentene-1-carboxylic ester salt represented by general formula (I) (wherein R1is an optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, or aralkyl group; and A is an inorganic or organic acid residue) with a metal boron hydride complex compound under the condition that the stoichiometric ratio of the amount of the metal boron hydride complex compound to the amount of the cis-4-amino-2-cyclopentene-1-carboxylic ester salt is 1-10.

  COPYRIGHT: (C)2006,JPO&NCIPI

  需要解决的问题：提供一种能够使用廉价易处理的反应物高选择性和高收率地生产顺式-1-氨基-4-羟甲基-2-环戊烯或其盐的方法。 解决方案：通过将通式（I）表示的顺式-4-氨基-2-环戊烯-1-羧酸酯盐（其中R1是可选取代的烷基、环烷基、烯基、炔基、芳基或芳烷基；A是无机或有机酸残基）与金属硼氢化合物复合物混合，在金属硼氢化合物复合物的量与顺式-4-氨基-2-环戊烯-1-羧酸酯盐的量的化学计量比为1-10的条件下，制备由式（II）表示的顺式-1-氨基-4-羟甲基-2-环戊烯或其盐。 版权所有：(C)2006，JPO&NCIPI
• 2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase
  作者：Timothy J. Hagen、Arija A. Bergmanis、Steven W. Kramer、Kam F. Fok、Albert E. Schmelzer、Barnett S. Pitzele、Lydia Swenton、Gina M. Jerome、Christine M. Kornmeier、William M. Moore、Linda F. Branson、Jane R. Connor、Pamela T. Manning、Mark G. Currie、E. Ann Hallinan

  DOI：10.1021/jm970840x

  日期：1998.9.1

  A series of substituted 2-iminopyrrolidines has been prepared and shown to be potent and selective inhibitors of the human inducible nitric oxide synthase (hiNOS) isoform versus the human endothelial nitric oxide synthase (heNOS) and the human neuronal nitric oxide synthase (hnNOS). Simple substitutions at the 3-, 4-, or 5-position afforded more potent analogues than the parent 2-iminopyrrolidine 1. The effect of ring substitutions on both potency and selectivity for the different NOS isoforms is described. Substitution at the 4- and 5-positions of the 2-iminopyrrolidine yielded both potent and selective inhibitors of hiNOS. In particular, (+)-cis-4-methyl-5-pentylpyrrolidin-2-imine, monohydrochloride (20), displayed potent inhibition of hiNOS (IC50 = 0.25 mu M) and selectivities of 897 (heNOS IC50/hiNOS IC50) and 13 (hnNOS IC50/hiNOS IC50) Example 20 was shown to be an efficacious inhibitor of NO production in the mouse endotoxin assay. Furthermore, 20 displayed in vivo selectivity, versus heNOS isoform, by not elevating blood pressure at multiples of the effective dose in the mouse.
• An extensive investigation on nucleation, growth parameters, crystalline perfection, spectroscopy, thermal, optical, microhardness, dielectric and SHG studies on potential NLO crystal – Ammonium Hydrogen l-tartarte
  作者：Redrothu Hanumantharao、S. Kalainathan、G. Bhagavannarayana、U. Madhusoodanan

  DOI：10.1016/j.saa.2012.10.044

  日期：2013.2

  Ammonium Hydrogen L-tartarte (AMT), an organic nonlinear optical crystal was grown by slow evaporation method at ambient temperature. Solubility, metastable zone width and induction period of Ammonium Hydrogen L-tartarte in aqueous solution were determined. Good quality crystals were selected and characterized by Single crystal XRD, HR-XRD, FT-IR, H-1 NMR, Mass, TGA-DTA, SEM, EDAX, optical and NLO studies. Single crystal XRD analysis revealed that the crystal system belongs to orthorhombic with cell parameters a = 7.65 angstrom, b = 7.85 angstrom and c = 11.07 angstrom. High-resolution-X-ray diffraction (HR-XRD) analysis was carried out to study the crystalline perfection of the grown crystal. H-1 NMR and FTIR spectrum thus confirmed the presence of functional groups of the grown crystal. Molecular mass of AMT was measured accurately by mass spectroscopic analysis. Surface features of the grown crystal were analyzed by SEM, AFM, chemical etching and the presence of elements in the compound was identified by EDAX analysis. Thermal behavior of the grown crystal has been studied by TG/DTA analysis. The recorded UV-Vis-NIR spectrum shows excellent transmission in the region of 190-1100 nm. The Vickers and Knoop's microhardness studies have been carried out on AMT crystals over a range of 10-50 g. Hardness anisotropy has been observed in accordance with the orientation of the crystal. Fluorescence spectral studies were carried in the range of 280-500 nm for the grown crystal. The SHG conversion efficiency and laser damage threshold were measured using an Nd: YAG laser (1064 nm). (c) 2012 Elsevier B.V. All rights reserved.