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(1S,2R)-1-((2R,3R,4S)-3-乙酰氨基-4-乙酰氧基-6-氯-6-(甲氧基羰基 | 132883-18-2

分子结构分类

有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物

中文名称

(1S,2R)-1-((2R,3R,4S)-3-乙酰氨基-4-乙酰氧基-6-氯-6-(甲氧基羰基

中文别名

——

英文名称

methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-2-chloro-2,3,5-trideoxy-D-glycero-D-galacto-2-nonulopyranosonate

英文别名

(1S,2R)-1-((2R,3R,4S)-3-acetamido-4-acetoxy-6-chloro-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate；methyl (4S,5R,6R)-5-acetamido-4-acetyloxy-2-chloro-6-[(1S,2R)-1,2,3-triacetyloxypropyl]oxane-2-carboxylate

(1S,2R)-1-((2R,3R,4S)-3-乙酰氨基-4-乙酰氧基-6-氯-6-(甲氧基羰基化学式

CAS

132883-18-2

化学式

C₂₀H₂₈ClNO₁₂

mdl

——

分子量

509.895

InChiKey

QGJGGAMXXWIKJR-VXUROWNDSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

582.1±50.0 °C(Predicted)
密度：

1.34±0.1 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

1
重原子数：

34
可旋转键数：

14
环数：

1.0
sp3杂化的碳原子比例：

0.7
拓扑面积：

170
氢给体数：

1
氢受体数：

12

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester	67670-69-3	C₂₀H₂₈ClNO₁₂	509.895
——	methyl S-4-methylphenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-2-nonulopyranosidonate	167084-05-1	C₂₇H₃₅NO₁₂S	597.64
——	N-acetyl neuraminic acid	131-48-6	C₁₁H₁₉NO₉	309.273
——	methyl 3,5--dideoxy--D--glycero--α,β--D--galaco--2--nonulsopyranosonate amino glycoside	73159-08-7	C₂₀H₂₉NO₁₃	491.449

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	(S)-2-O-benzyl-1-O--3-O-monochloroacetylglycerol	132928-97-3	C₃₂H₄₂ClNO₁₆	732.136
——	methyl (4-pentenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-D-galacto-nonulopyranosid)onate	875136-17-7	C₂₅H₃₇NO₁₃	559.568
——	allyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,54-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosonic acid methyl ester	73159-07-6	C₂₃H₃₃NO₁₃	531.514
——	methyl (2R,4S,5R,6R)-5-[[2-[(2R,4S,5R,6R)-5-acetamido-4-acetyloxy-2-methoxycarbonyl-6-[(1S,2R)-1,2,3-triacetyloxypropyl]oxan-2-yl]oxyacetyl]amino]-4-hydroxy-2-prop-2-enoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate	474452-49-8	C₃₅H₅₂N₂O₂₂	852.798
——	methyl (2R,4S,5R,6R)-5-[[2-[(2R,4S,5R,6R)-5-acetamido-4-acetyloxy-2-methoxycarbonyl-6-[(1S,2R)-1,2,3-triacetyloxypropyl]oxan-2-yl]oxyacetyl]amino]-4-acetyloxy-2-prop-2-enoxy-6-[(1S,2R)-1,2,3-triacetyloxypropyl]oxane-2-carboxylate	474452-50-1	C₄₃H₆₀N₂O₂₆	1020.95
——	Neu5Ac(2-6)Gal	875136-19-9	C₃₂H₄₇NO₁₈	733.721
——	O--(2-3)-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl trichloroacetimidate	113421-35-5	C₃₄H₄₅Cl₃N₂O₂₁	924.091
——	O--(2-3)-2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl trichloroacetimidate	113421-28-6	C₃₄H₄₅Cl₃N₂O₂₁	924.091
——	(2R,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((S)-2-benzyloxy-3-hexadecanoyloxy-propoxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester	126568-80-7	C₄₆H₇₁NO₁₆	894.067
——	(2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((S)-2-benzyloxy-3-hexadecanoyloxy-propoxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester	126568-92-1	C₄₆H₇₁NO₁₆	894.067
——	(2R,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((R)-2-benzyloxy-3-hexadecanoyloxy-propoxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester	126568-81-8	C₄₆H₇₁NO₁₆	894.067
——	(2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((R)-2-benzyloxy-3-hexadecanoyloxy-propoxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester	126568-89-6	C₄₆H₇₁NO₁₆	894.067
——	(2R,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((S)-2-benzyloxy-3-dodecanoyloxy-propoxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester	126610-80-8	C₄₂H₆₃NO₁₆	837.959
——	(2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((S)-2-benzyloxy-3-dodecanoyloxy-propoxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester	126568-93-2	C₄₂H₆₃NO₁₆	837.959
——	(2R,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((S)-2-benzyloxy-3-octanoyloxy-propoxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester	126568-90-9	C₃₈H₅₅NO₁₆	781.852
——	(2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((S)-2-benzyloxy-3-octanoyloxy-propoxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester	126568-94-3	C₃₈H₅₅NO₁₆	781.852
——	2-(trimethylsilyl)ethyl O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2→3)-β-D-galactopyranoside	1572266-27-3	C₃₁H₅₁NO₁₈Si	753.827
——	2-(trimethylsilyl)ethyl O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)(2→3)-2,4,6-tri-O-acetyl-β-D-galactopyranoside	223452-42-4	C₃₇H₅₇NO₂₁Si	879.939
——	(R)-2-O-benzyl-3-O-tert-butyldimethylsilyl-1-O-glycerol	132928-95-1	C₃₆H₅₅NO₁₅Si	769.916
——	methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-3-C-(prop-2'-enyl)-β-D-erythro-L-gluconon-2-ulopyranosonate	132591-29-8	C₂₃H₃₃NO₁₃	531.514
——	2-(trimethylsilyl)ethyl O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)(2→3)-2,6-di-O-benzyl-β-D-galactopyranoside	177280-26-1	C₄₅H₆₃NO₁₈Si	934.077
——	(1S,2R)-1-((3aR,4R,6R,7aS)-6-(methoxycarbonyl)-6-(octyloxy)-2-oxohexahydro-4H-pyrano[3,4-d]oxazol-4-yl)propane-1,2,3-triyl triacetate	1590365-41-5	C₂₅H₃₉NO₁₂	545.584
——	(1S,2R)-1-((3aR,4R,6R,7aS)-6-(cyclohexyloxy)-6-(methoxycarbonyl)-2-oxohexahydro-4H-pyrano[3,4-d]oxazol-4-yl)propane-1,2,3-triyl triacetate	1590365-43-7	C₂₃H₃₃NO₁₂	515.515
——	methyl (octyl 5-acetamido-7,8,9-tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-D-glycero-α-D-galactonon-2-ulopyranoside)onate	934592-14-0	C₂₇H₄₁NO₁₃	587.621
——	methyl (cyclohexyl 5-acetamido-7,8,9-tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranoside)onate	1590365-50-6	C₂₅H₃₅NO₁₃	557.552
——	O-[methyl (7,8,9-tri-O-acetyl-4,5-O,N-carbonyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosyl)onate]-(2->6)-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose	929882-36-0	C₂₉H₄₁NO₁₇	675.641
——	O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2→3)-(2,4,6-tri-O-acetyl-β-D-galactopyranosyl)-(1→1)-(2S,3R,4E)-2-azido-3-O-benzoyl-4-octadecene-1,3-diol	1572266-36-4	C₅₇H₈₂N₄O₂₃	1191.29
——	methyl (phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-selenononulopyranosid)onate	131569-89-6	C₂₆H₃₃NO₁₂Se	630.508
——	2,6-anhydro-3,5-dideoxy-5-acetamido D-erythro-L-manno-nononic acid	119068-34-7	C₁₁H₁₉NO₈	293.274
——	methyl (methyl 5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate	643751-69-3	C₁₃H₂₃NO₉	337.327
——	methyl {2-O-[2-(difluoromethyl)-4-aminophenyl]-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-galacto-2-nonulopyranosid}onate	873014-23-4	C₂₇H₃₄F₂N₂O₁₃	632.569
——	Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-2,6-anhydro-3,5-dideoxy-D-glycero-D-talo-non-2-enonate	78918-92-0	C₂₀H₂₇NO₁₂	473.434
——	methyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate	73960-72-2	C₂₀H₂₇NO₁₂	473.434
——	methyl {2-O-[2-(difluoromethyl)-4-nitrophenyl]-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid}onate	864933-93-7	C₂₇H₃₂F₂N₂O₁₅	662.552
——	methyl [2-O-(2-formyl-4-nitrophenyl)-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-galacto-2-nonulopyranosid]onate	864933-92-6	C₂₇H₃₂N₂O₁₆	640.555
——	methyl 5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-3,5-dideoxy-D-glycero-D-talo-non-2-enoate	80973-54-2	C₁₈H₂₅NO₁₁	431.397
——	methyl N-acetylneuraminic acid	202343-13-3	C₁₂H₂₁NO₉	323.3
——	4-acetoxy-5-(acetylamino)-2-{4-[(3-carboxypropionyl)amino]-2-(difluoromethyl)phenoxy}-6-(1,2,3-triacetoxypropyl)tetrahydropyran-2-carboxylic acid methyl ester	873014-24-5	C₃₁H₃₈F₂N₂O₁₆	732.643
——	methyl 5-N-acetyl-3,5-dideoxy-2-O-(3-methoxy-2-pyridyl)-4,7,8,9-tetra-O-acetyl-D-glycero-D-galacto-2-nonulopyranosonate	496924-66-4	C₂₆H₃₄N₂O₁₄	598.561
——	O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-(β-D-galactopyranosyl)-(1→1)-(2S,3R,4E)-2-azido-4-octadecene-1,3-diol	1572266-41-1	C₃₅H₆₂N₄O₁₅	778.895
——	O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-(β-D-galactopyranosyl)-(1→1)-(2S,3R,4E)-2-amino-4-octadecene-1,3-diol	1572266-43-3	C₃₅H₆₄N₂O₁₅	752.898
——	methyl (3aR,4R,6S,7aS)-3-acetyl-6-(4-methylphenyl)sulfanyl-2-oxo-4-[(1S,2R)-1,2,3-triacetyloxypropyl]-3a,4,7,7a-tetrahydropyrano[3,4-d][1,3]oxazole-6-carboxylate	1151942-33-4	C₂₆H₃₁NO₁₂S	581.598
——	methyl (4-methylcoumarin-7-yl-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate	59361-08-9	C₃₀H₃₅NO₁₅	649.606
——	methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-2,6-anhydro-3,5-dideoxy-3-C-(prop-2′-enyl)-D-glycero-D-galacto-non-2-enonate	1262101-29-0	C₂₃H₃₁NO₁₂	513.499
——	4-acetoxy-5-(acetylamino)-2-[2-(difluoromethyl)-4-(3-{6-[5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoylamino]hexylcarbamoyl}propionylamino)phenoxy]-6-(1,2,3-triacetoxypropyl)tetrahydropyran-2-carboxylic acid methyl ester	873014-25-6	C₄₇H₆₆F₂N₆O₁₇S	1057.13
5-乙酰氨基-7,8,9-O-三乙酰基-2,6-脱水-4-叠氮-3,4,5-三脱氧-D-甘油-D-半乳-2-壬烯酸甲酯	methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate	130525-58-5	C₁₈H₂₄N₄O₁₀	456.409
——	methyl 5-N-acetyl-3,5-dideoxy-2-O-(3-methoxy-2-pyridyl)-D-glycero-D-galacto-2-nonulopyranosonate	496924-67-5	C₁₈H₂₆N₂O₁₀	430.412
——	allyl 2',3'-O,N⁴-triacetylcytidin-5'-yl methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphite	188786-06-3	C₃₈H₅₁N₄O₂₂P	946.81
——	2',3'-O,N⁴-triacetylcytidin-5'-yl methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate	149002-88-0	C₃₅H₄₇N₄O₂₃P	922.745
——	methyl (2R,4S,5R,6R)-5-acetamido-2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-3,4-diacetyloxyoxolan-2-yl]methoxy-prop-2-enoxyphosphoryl]oxy-4-acetyloxy-6-[(1S,2R)-1,2,3-triacetyloxypropyl]oxane-2-carboxylate	194665-72-0	C₃₈H₅₁N₄O₂₃P	962.81
——	4-MUNANA	59322-44-0	C₂₁H₂₅NO₁₁	467.43
——	cytidine-5'-monophosphono-N-acetylneuraminic acid	3063-71-6	C₂₀H₃₁N₄O₁₆P	614.457
扎那米韦	zanamivir	139110-80-8	C₁₂H₂₀N₄O₇	332.313
甲基(3aR,4R,7aR)-2-甲基-4-[(1S,2R)-1,2,3-三乙酰氧基丙基]-3a,7a-二氢-4H-吡喃并[3,4-d][1,3]恶唑-6-羧酸酯	methyl (3aS,4R,7aR)-4-[(1S,2R)-1,2,3-triacetoxy-propyl]-2-methyl-3a,7a-dihydro-4H-pyrano[3,4-d][1,3]oxazole-6-carboxylate	78850-37-0	C₁₈H₂₃NO₁₀	413.381

反应信息

作为反应物：

描述：

(1S,2R)-1-((2R,3R,4S)-3-乙酰氨基-4-乙酰氧基-6-氯-6-(甲氧基羰基在 palladium on activated charcoal 二乙胺基三氟化硫、四丁基溴化铵、氢气、 sodium carbonate 、 1-羟基苯并三唑、 caesium carbonate 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺、三乙胺、 N,N-二异丙基乙胺作用下，以甲醇、二氯甲烷、氯仿、水、 N,N-二甲基甲酰胺为溶剂，反应 33.0h，生成

参考文献：

名称：

基于机制的神经氨酸酶捕获流感病毒探针的设计。

摘要：

DOI：

10.1002/anie.200501738
作为产物：

描述：

(1S,2R)-1-((2R,3R,4S,6R)-3-acetamido-4,6-diacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate 在盐酸、乙酰氯作用下，以乙醚为溶剂，生成 (1S,2R)-1-((2R,3R,4S)-3-乙酰氨基-4-乙酰氧基-6-氯-6-(甲氧基羰基

参考文献：

名称：

Bandgar, Babasaheb P.; Hartmann, Michael; Schmid, Walther, Liebigs Annalen der Chemie, 1990, # 12, p. 1185 - 1195

摘要：

DOI：

点击查看最新优质反应信息

文献信息

Use of Phenyl 2-α-Selenoglycosides of N-Acetylneuraminic Acid as a Glycosyl Donor for the Glycosylation Reactions

作者：Kiyoshi Ikeda、Yuji Sugiyama、Kiyoshi Tanaka、Masayuki Sato

DOI：10.1016/s0960-894x(02)00400-6

日期：2002.9

Phenyl 2-alpha-selenoglycosides of Neu5Ac were successfully prepared from the corresponding peracetylated chloro derivative of Neu5Ac 1 and phenylselenol in the presence of N,N-di-isopropylethylamine in excellent yields. The reaction of with various alcohols was effectively catalyzed by NIS/TfOH or DMTST to produce a variety of glycosides in moderate yields. Selective activation of over phenyl 2-alpha-thioglycoside

在N，N-二异丙基乙胺存在下，由Neu5Ac 1和苯硒酚的相应的过乙酰化氯代衍生物成功制备了Neu5Ac的苯基2-α-硒代糖苷。NIS / TfOH或DMTST有效地催化了与各种醇的反应，从而以中等收率产生了多种糖苷。还实现了Neu5Ac的苯基2-α-硫代糖苷与AgOTf / K（2）CO（3）的选择性活化。
Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

作者：Daniel E. K. Kabotso、David Smiley、John P. Mayer、Vasily M. Gelfanov、Diego Perez-Tilve、Richard D. DiMarchi、Nicola L. B. Pohl、Fa Liu

DOI：10.1021/acs.jmedchem.0c00266

日期：2020.6.11

that strengthen its physical stability without compromising its biological properties. Complex polysialic acids (PSAs) exist naturally and provide a means to enhance the physical properties of peptide therapeutics. A set of insulin analogues site-specifically derivatized with sialic acid were prepared in an overall yield of 50–60%. Addition of a single or multiple sialic acids conferred remarkable

天然胰岛素易受生物物理聚集和原纤维形成的影响，手动搅拌和升高的温度会促进天然胰岛素的生成。可以通过鉴定在不损害其生物学特性的情况下增强其物理稳定性的化学修饰来增强药物的安全性以及将其应用于其他给药方式。复杂的聚唾液酸（PSA）自然存在，并提供增强肽治疗剂物理特性的手段。制备了一组用唾液酸位点特异性衍生的胰岛素类似物，总产率为50-60％。添加一种或多种唾液酸可显着增强人胰岛素的生物物理稳定性，同时保持其效力。相对于天然激素来说，开始纤维化的时间延长了十倍以上。这些结果表明，简化的唾液酸缀合物在增加治疗性肽的稳定性方面代表了复杂的天然PSA的可行替代方案。
Fluorogenic sialic acid glycosides for quantification of sialidase activity upon unnatural substrates

作者：Cristina Y. Zamora、Marc d’Alarcao、Krishna Kumar

DOI：10.1016/j.bmcl.2013.03.076

日期：2013.6

Herein we report the synthesis of N-acetyl neuraminic acid derivatives as 4-methylumbelliferyl glycosides and their use in fluorometrically quantifying human and bacterial sialidase activity and substrate specificities. We found that sialidases in the human promyelocytic leukemic cell line HL60 were able to cleave sialic acid substrates with fluorinated C-5 modifications, in some cases to a greater

在本文中，我们报告了N-乙酰神经氨酸衍生物作为 4-甲基伞形酮糖苷的合成及其在荧光定量人类和细菌唾液酸酶活性和底物特异性中的用途。我们发现人早幼粒细胞白血病细胞系 HL60 中的唾液酸酶能够切割带有氟化 C-5 修饰的唾液酸底物，在某些情况下比天然N-乙酰基官能团的切割程度更大。人类唾液酸酶亚型还能够切割具有庞大和疏水性 C-5 修饰的非天然底物。相比之下，我们发现从产气荚膜梭菌中分离的细菌唾液酸酶在这个位置对唾液酸衍生化的耐受性较低，几乎没有观察到这些糖苷的裂解。根据我们的结果，我们得出结论，人类唾液酸酶活性是利用非天然唾液酸衍生物进行唾液酸代谢糖工程研究的一个重要因素。我们的荧光探针有助于进一步了解细胞环境中人类唾液酸酶的活性和底物特异性。
One-Step Stereocontrolled Synthesis of α-Anomeric Carboxylic Acid Esters from Unprotected Glycosyl Donors: A Water-Soluble Aspirin Pro-Drug Analogue

作者：Stephen Hanessian、Vincent Mascitti、Pu-Ping Lu、Hideki Ishida

DOI：10.1055/s-2002-34372

日期：——

The reaction of 2-(3-methoxypyridyl) Î²-d-gluco- and d-galactopyranosides with various carboxylic acids affords the corresponding Î±-1-esters in high yields. Aspirin can be solubilized in water as the Î±-d-galactopyranosyl ester.

2-(3-甲氧基吡啶基)的β-D-葡萄糖苷和D-半乳糖苷与多种羧酸反应，以高产率生成相应的α-1-酯。阿司匹林可以作为α-D-半乳糖苷酯在水中的可溶形式存在。
Synthesis of CMP-sialic acid conjugates: Substrates for the enzymatic synthesis of natural and designed sialyl oligosaccharides

作者：Mark D. Chappell、Randall L. Halcomb

DOI：10.1016/s0040-4020(97)00370-0

日期：1997.8

The syntheses of several congeners of CMP-NeuAc are described. These compounds are substrates for enzymatic glycosylation.

描述了CMP-NeuAc的几种同源物的合成。这些化合物是酶促糖基化的底物。