（±）-丙酰肉碱氯化物 | 18828-58-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: （±）-丙酰肉碱氯化物
• 英文名称: propionylcarnitine hydrochloride
• 英文别名: O-Propionylcarnitinhydrochlorid；(+/-)-propionylcarnitine chloride；3-Propanoyloxy-4-(trimethylazaniumyl)butanoate;hydrochloride
• CAS: 18828-58-5
• 化学式: C₁₀H₂₀NO₄*Cl
• 分子量: 253.726
• InChiKey: KTFMPDDJYRFWQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.51
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  甲醇 、 （±）-丙酰肉碱氯化物 在 盐酸 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Kinetic and molecular orbital analyses of dicarboxylic acylcarnitine methylesterification show that derivatization may affect the screening of newborns by tandem mass spectrometry

  摘要：

  Newborns are routinely screened for organic acidemias by acylcarnitine analysis. We previously reported the partial catalytic methylesterification of dicarboxylic acylcarnitines by benzenesulfonic acid moiety in the solid extraction cartridge during extraction from serum. Since the diagnosis of organic acidemias by tandem mass spectrometry is affected by the higher molecular weight of these derivatized acylcarnitines, we investigated the methylesterification conditions. The kinetic constants for the methylesterification of carboxyl groups on the acyl and carnitine sides of carnitine were 2.5 and 0.24 h (1), respectively. The physical basis underlying this difference in methylesterification rates was clarified theoretically, illustrating that methylesterification during extraction proceeds easily and must be prevented. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.11.016
• 作为产物：
  描述：

  DL-肉碱 、 丙酰氯 生成 （±）-丙酰肉碱氯化物
  参考文献：
  名称：

  CAVAZZA, C.

  摘要：

  DOI：

文献信息

• [EN] L-CARNITINE AND ALKANOYL L-CARNITINE PHYTATES AND PROCESS FOR PREPARING THE SAME<br/>[FR] PHYTATES DE L-CARNITINE ET D'ALCANOYLE L-CARNITINE, ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：SCIAN LAB LLC

  公开号：WO2010005465A1

  公开（公告）日：2010-01-14

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1 :1 to 6:1, wherein: n = 1-6; R1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和烷酰基L-肉碱盐与一般公式(I)的植酸，以及制备这些化合物的过程，其中L-肉碱或其烷酰衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n = 1-6；R1为植酸阴离子；R为氢、具有2-12个碳原子的直链烷酰基团或具有2-12个碳原子的支链烷酰基团。
• L-carnitine and alkanoyl L-carnitine phytates and process for preparing the same
  申请人：Chen Jian

  公开号：US20100317890A1

  公开（公告）日：2010-12-16

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1:1 to 6:1, wherein: n=1-6; R 1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和辛酰基L-肉碱盐与通式(I)的植酸，以及其制备方法，其中L-肉碱或其辛酰基衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n=1-6；R1是植酸阴离子；R是氢，具有2-12个碳原子的直链辛酰基或具有2-12个碳原子的支链辛酰基。
• Use of L-Carnitine, salts and derivatives thereof for reducing or preventing fatigue and improving cognitive function
  申请人：Lonza Ltd

  公开号：EP2508179A1

  公开（公告）日：2012-10-10

  The invention relates to the use of L-carnitine, a salt of L-carnitine, a derivative of L-carnitine and/or salt of a derivative of L-carnitine, as well as respective methods and compositions, for reducing or preventing fatigue and/or for improving cognitive function in an animal. The animal is preferably a healthy individual and the use is preferably a non-therapeutic use.

  本发明涉及使用左旋肉碱、左旋肉碱盐、左旋肉碱衍生物和/或左旋肉碱衍生物盐，以及相应的方法和组合物，用于减轻或预防动物的疲劳和/或改善认知功能。该动物最好是健康个体，使用最好是非治疗性使用。
• SALTS OF CARNITINE DERIVATIVES AND METHODS OF PRODUCTION
  申请人：ThermoLife International, LLC

  公开号：US20150166466A1

  公开（公告）日：2015-06-18

  Disclosed are salts, such as nitrates, of acetyl-L-carnitine and propionyl-L-carnitine and methods of making the compounds.

  本发明涉及乙酰-L-肉碱和丙酰-L-肉碱的盐，如硝酸盐，以及制备这些化合物的方法。
• [EN] ANIONIC HYDROGEL MATRICES WITH PH DEPENDENT MODIFIED RELEASE AS DRUG CARRIERS<br/>[FR] MATRICES D'HYDROGEL ANIONIQUE A LIBERATION MODIFIEE DEPENDANT DU PH COMME VECTEURS DE MEDICAMENT
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2005094792A1

  公开（公告）日：2005-10-13

  Compositions with pH-dependent modified release are described, consisting of hydrogel matrices containing one or more active ingredients, in which said matrices are suitable for releasing said active ingredients in a prolonged manner in given sites of the body.

  本发明描述了具有pH依赖性改性释放的组合物，包括含有一种或多种活性成分的水凝胶基质，其中所述基质适用于在身体的给定部位以延长的方式释放所述活性成分。