/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
解毒与急救
/SRP:/ 高级治疗：对于无意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注D5W /SRP: "保持开放"，最低流量/。如果出现低血容量的迹象，使用0.9%生理盐水（NS）或乳酸林格氏液。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。使用地西泮或劳拉西泮治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。 /Poisons A and B/
/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/
/BIOMONITORING/ As concern regarding the toxic effects of bisphenol A (BPA) grows, BPA in many consumer products is gradually being replaced with compounds such as bisphenol S (BPS). Nevertheless, data on the occurrence of BPS in human specimens are limited. In this study, 315 urine samples, collected from the general populations in the United States, China, India, Japan, Korea, Kuwait, Malaysia, and Vietnam, were analyzed for the presence of total BPS (free plus conjugated) concentrations by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). BPS was detected in 81% of the urine samples analyzed at concentrations ranging from below the limit of quantitation (LOQ; 0.02 ng/mL) to 21 ng/mL (geometric mean: 0.168 ng/mL). The urinary BPS concentration varied among countries, and the highest geometric mean concentration (1.18 ng/mLor 0.933 ug/g creatinine (Cre)) of BPS was found in urine samples from Japan, followed by the United States (0.299 ng/mL, 0.304 ug/g Cre), China (0.226 ng/mL, 0.223 ug/g Cre), Kuwait (0.172 ng/mL, 0.126 ug/g Cre), and Vietnam (0.160 ng/mL, 0.148 ug/g Cre). Median concentrations of BPS in urine samples from the Asian countries were 1 order of magnitude lower than the median concentrations reported earlier for BPA in the same set of samples, with the exception of samples from Japan. There were no significant differences in BPS concentrations between genders (male versus female), or among age groups (categorized as = 19, 20-29, 30-39, 40-49, and = 50 years), or races (Caucasian versus Asian). The daily intake (EDI) of BPS was estimated on the basis of urinary concentrations using a simple pharmacokinetic approach. The median EDI values of BPS in Japan, China, United States, Kuwait, Vietnam, Malaysia, India, and Korea were 1.67, 0.339, 0.316, 0.292, 0.217, 0.122, 0.084, and 0.023 ug/person, respectively.
/OTHER TOXICITY INFORMATION/ In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles. In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some insights about the structure-activity relationships of these two chemicals and their metabolites could be gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver phase-I biotransformation.
2,2'-磺酰基二苯酚 以
甲醇 、 水 为溶剂，
生成 4-hydroxycyclohexa-2,5-dien-1-one, sodium salt
参考文献：
名称：
燃料电池膜离聚物的氧化和光化学稳定性
摘要：
为了预测基于磺化聚醚酮（PEK）和聚砜（PSU）的新型质子传导聚合物膜的羟基自由基引发的降解，选择了三种非氟化芳族化合物作为EPR实验的模型化合物，旨在鉴定HO的产物。与这些单体的自由基反应。H 2 O 2的光解被选为HO的来源。部首。区分HO 。在存在和不存在H 2 O 2的条件下，进行了单体直接光解引起的自由基自由基攻击。对4,4'-磺酰基双[苯酚]（SBP），双酚A（= 4,4'-亚丙基双[苯酚]；BPA）和[1,1'-联苯] -4,4'-二醇（BPD）。在pH≥HO的p K A时。和H 2 O 2，模型化合物与O 2 .-或1 O 2之间的反应是在我们的EPR光谱中在此pH范围内观察到的最可能的苯氧基和“半醌”自由基的方法。大量新的自由基提供了芳环多羟基化的证据。在低pH下进行的研究对于理解聚合物电解质燃料电池（PEFC）的降解特别重要。但是，化学反应强烈依赖于pH值，考虑到高电流
A novel series of pivaloyloxy benzene derivatives has been identified as potent and selective human neutrophil elastase (HNE) inhibitors. Convergent syntheses were developed in order to identify the inhibitors which are intravenously effective in an animal model. A compound of particular interest is the sulfonanilide-containing analogues. Structure-activity relationships are discussed. Structural requirements
Electrophotographic photoconductor, process for forming an image, image forming apparatus and a process cartridge for the same
申请人：——
公开号：US20030190540A1
公开（公告）日：2003-10-09
Providing an electrophotographic photoconductor comprising a conductive support and a photoconductive layer disposed on the photoconductive support; wherein the photoconductive layer contains an azo compound expressed by a general formula <<1>>.
Ar &Parenopenst;N═N—Cp)
n
general formula <<1>>
(in the general formula <<1>>, Ar expresses one of a substituted or non-substituted aromatic carbon hydride group and heterocyclic ring aromatic series group which can be combined by way of a bond group; Cp expresses a coupler residual group; n expresses an integer of one of 1, 2, 3, and 4; at least one of the Cp is a coupler residual group selected from one of the following general formulae <<2>>, <<3>>, and <<4>>.)
1
Polybenzoxazines are phenolic-like materials that possess dimensional and thermal stability, and they release no by-products during their polymerization. In this study, a new class of benzoxazine-containing monomers has been prepared from renewable resource (eugenol, a natural phenol obtained from clove oil), paraformaldehyde and various aromatic diamines. The structures of the monomers were supported by Fourier Transform Infrared (FT-IR), 1H-NMR and 13C-NMR spectral analysis, proving the existence of the benzoxazine ring containing eugenol moiety in its molecular structure. The monomers were polymerized/cured via ring-opening polymerization by heating as indicated by FT-IR and Differential Scanning Calorimetry (DSC). This is confirmed by the disappearance of the peaks due to oxazine ring (942 cm−1). The exothermic peak associated with curing was observed from 170 °C to 250 °C. The thermal and mechanical properties of the polybenzoxazines were investigated through thermogravimetric analysis (TGA) and dynamic mechanical analysis (DMA). The temperatures corresponding to 5% and 10% weight loss is from 240 to 295 °C and from 290 to 340 °C, respectively. The completely cured materials could achieve char yields up to 36.5% at 800 °C in nitrogen atmosphere. DMA revealed that the glass transition temperatures of PBz-SUL and PBz-PHE were higher than that of PBz-DDS and PBz-OXY.
申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
公开号：US20160130205A1
公开（公告）日：2016-05-12
The present invention concerns a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C—HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C—HE bond, wherein the reaction takes place in the presence of an effective quantity of a. a catalytic system comprising a ligand and at least a metal-based catalyst, such a metal catalyst being chosen among iron or copper compounds proviso that only a single metal is present.
