申请人：University of Kentucky
公开号：US20150259356A1
公开（公告）日：2015-09-17
The present invention provides compounds of the formula (I)
wherein:
X
1
, X
2
and X
3
are heteroatoms;
R
4
, R
5
, R
6
, R
7
, R
8
, R
9
and R
10
are independently selected from H, halo, —OH, —NO
2
, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and
Z is optionally substituted C
1-8
straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR
1
—, —C(O)NR
1
NR
2
—, —C(O)O—, —OC(O)—, —NR
1
CO
2
—, —O—, —NR
1
C(O)NR
2
—, —OC(O)NR
1
—, —NR
1
NR
2
—, —NR
1
C(O)—, —S—, —SO—, —SO
2
—, —NR
1
—, —SO
2
NR
1
—, —NR
1
R
2
, or —NR
1
SO
2
—, wherein R
1
and R
2
are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR
1
R
2
, R
1
and R
2
optionally together with the nitrogen atom form an optionally substituted 5-12 membered ring, said ring optionally comprising 1 or more heteroatoms or a group selected from —CO—, —SO—, —SO
2
— and —PO—; or
a pharmaceutically acceptable salt, ester or prodrug thereof.
本发明提供了以下式（I）的化合物：
其中：
X1，X2和X3是杂原子；
R4，R5，R6，R7，R8，R9和R10分别选自H，卤素，—OH，—NO2，—CN和可选地取代的脂肪族，环烷基，杂环烷基，芳基或杂芳基；以及
Z是可选地取代的C1-8直链或支链脂肪族，可选地含有1个或多个双键或三键，其中一个或多个碳原子可选地被R*取代，其中R*是可选地取代的环烷基，杂环烷基，芳基或杂芳基；氨基酸残基，H，—CN，—C（O）—，—C（O）C（O）—，—C（O）NR1—，—C（O）NR1NR2—，—C（O）O—，—OC（O）—，—NR1CO2—，—O—，—NR1C（O）NR2—，—OC（O）NR1—，—NR1NR2—，—NR1C（O）—，—S—，—SO—，—SO2—，—NR1—，—SO2NR1—，—NR1R2，或—NR1SO2—，其中R1和R2分别选自H和可选地取代的脂肪族，环烷基，杂环烷基，芳基或杂芳基；或者当R*为NR1R2时，R1和R2可选地与氮原子一起形成一个可选地取代的5-12成员环，所述环可选地包含1个或多个杂原子或从—CO—，—SO—，—SO2—和—PO—中选择的基团；或者其药学上可接受的盐，酯或前药。
