4-乙基双环己基酮 | 149975-97-3

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-乙基双环己基酮
• 英文名称: (1’r,4’r)-4’-ethyl-[1,1’-bi(cyclohexan)]-4-one
• 英文别名: 4-(4-ethylcyclohexyl)cyclohexan-1-one
• CAS: 149975-97-3；150763-13-6
• 化学式: C₁₄H₂₄O
• 分子量: 208.344
• InChiKey: ICCIOWLZPJIEBA-UHFFFAOYSA-N

物化性质

• 沸点：
  299.4±8.0 °C(Predicted)
• 密度：
  0.944

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

制备方法与用途

用途

4-乙基双环己基酮是一种酮类衍生物，主要用作医药中间体。

反应信息

• 作为反应物：
  描述：

  4-乙基双环己基酮 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium acetate 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 8.5h， 生成 rac-2-((1RS,1‘r,4’RS)-4’-ethyl-[1,1‘-bi(cyclohexan)]-3-en-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  参考文献：
  名称：

  [EN] DIMETHYLAMINOETHANOL SALT OF A GLP-1 RECEPTOR MODULATOR
  [FR] SEL DE DIMÉTHYLAMINOÉTHANOL D'UN MODULATEUR DU RÉCEPTEUR GLP -1

  摘要：

  Crystalline 2-羟基-N,N-二甲基乙铵1-(2-(5-(叔丁基)-噻吩-2-甲酰胺基)-3-(4-(5-(4'-乙基-[1,1'-双(环己烷)]-3-烯-4-基)嘧啶-2-基)苯基)丙酰基)氮杂环丁烷-3-羧酸盐，以及与同一化合物的合成和治疗方法相关的方法。

  公开号：

  WO2018064476A1

文献信息

• Electrochemical dehydrogenative cross-coupling of xanthenes with ketones
  作者：Yong-Zheng Yang、Yan-Chen Wu、Ren-Jie Song、Jin-Heng Li

  DOI：10.1039/d0cc02580a

  日期：——

  functionalized 9-alkyl-9H-xanthenes was developed. This method enables the formation of a new C(sp3)–C(sp3) bond through release of H2 as the major byproduct at room temperature, and features mild conditions, high atom economy, excellent functional-group tolerance, scalability and facile applications in pharmaceutical chemistry.

  开发了一种新的无氧黄酮和酮的无外部氧化剂的电化学脱氢交联反应，用于制备功能化的9-烷基-9 H-黄嘌呤。该方法能够通过在室温下释放H 2作为主要副产物而形成新的C（sp 3）–C（sp 3）键，并且具有温和的条件，高原子经济性，出色的官能团耐受性，可扩展性和在药物化学中的简便应用。
• Fluorinated anthracenes, and their use in liquid-crystal mixtures
  申请人：Clariant International Ltd.

  公开号：US20030118749A1

  公开（公告）日：2003-06-26

  The invention relates to compounds of the formula (I) and to liquid-crystal mixtures comprising these compounds and to the use thereof in liquid-crystal displays.

  该发明涉及公式（I）的化合物，以及包含这些化合物的液晶混合物和在液晶显示器中使用它们的方法。
• DIFLUOROBENZENE DERIVATIVE AND NEMATIC LIQUID CRYSTAL COMPOSITION USING THE SAME
  申请人：Kawakami Shotaro

  公开号：US20090050843A1

  公开（公告）日：2009-02-26

  A nematic liquid crystal composition of the present invention includes 10 to 80% by mass of either one or at least two compounds represented by general formula (I) as a first component; and 20 to 70% by mass of either one or at least two compounds represented by general formula (II) as a second component, wherein a dielectric constant anisotropy is negative. The use of this nematic liquid crystal composition can provide a highly reliable liquid crystal display element capable of maintaining a high voltage-holding ratio even in a high temperature region, and achieving quick responsiveness without reducing the cell gap.

  本发明的向列型液晶组合物包括以下成分：第一成分为一种或至少两种由通式（I）表示的化合物，质量百分含量为10%至80%；第二成分为一种或至少两种由通式（II）表示的化合物，质量百分含量为20%至70%。其中，介电常数各向异性为负。使用这种向列型液晶组合物可以提供高度可靠的液晶显示元件，即使在高温区域也能保持高电压保持比，并实现快速响应，而不降低单元间距。
• Nematic Liquid Crystal Composition And Liquid Crystal Display Device Using The Same
  申请人：Kawakami Shotaro

  公开号：US20080111107A1

  公开（公告）日：2008-05-15

  The present invention provides a liquid crystal composition having a negative dielectric anisotropy whose absolute value is large, and a low viscosity, and also provides a VA type liquid crystal element using the same. Disclosed is a liquid crystal composition containing a compound represented by the general formula (I) and an alkenyl compound represented by the general formula (II): By combining the liquid compounds according to the present invention, a liquid crystal composition having a low viscosity and a negative dielectric anisotropy could be obtained while nearly maintaining physical properties such as refractive anisotropy. By using the composition, a liquid crystal element having excellent reliability, capable of maintaining a high voltage retention until a high temperature region, is provided, and the display is very applicable as a VA type, ECB type, or IPS type liquid crystal display, and is particularly effective for speeding up response without thinning cell gaps.

  本发明提供了一种具有较大绝对值的负介电各向异性和低粘度的液晶组合物，并且还提供了使用该组合物的VA型液晶元件。本发明揭示了一种包含通式（I）所代表的化合物和通式（II）所代表的烯基化合物的液晶组合物。通过将本发明中的液态化合物组合，可以获得具有低粘度和负介电各向异性的液晶组合物，同时几乎保持折射各向异性等物理性质。通过使用该组合物，提供了具有优异可靠性的液晶元件，能够保持高电压保持能力直至高温区域，并且在VA型、ECB型或IPS型液晶显示器中非常适用，特别是在不减小单元间距的情况下加速响应。
• FIVE-RING LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：Kobayashi Masahide

  公开号：US20120074355A1

  公开（公告）日：2012-03-29

  The invention provides a liquid crystal compound having a high stability to heat, light or the like, a nematic phase in a wide temperature range, a small viscosity, a suitable optical anisotropy (especially, a relatively small optical anisotropy), a large elastic constant K 33 and a suitable dielectric anisotropy (especially, a relatively large dielectric anisotropy), which is represented by formula (1-1). For example, R 1 and R 2 are alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkoxy having 1 to 9 carbons; the ring A 1 and the ring A 2 is 1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene or 3,5-difluoro-1,4-phenylene; and m and n are 0, 1, 2 or 3, and the sum of m and n is 3.

  本发明提供了一种液晶化合物，具有高稳定性，耐热、耐光等性能，在广泛的温度范围内具有向列相、粘度小、适当的光学各向异性（尤其是相对较小的光学各向异性）、大的弹性常数K33和适当的介电各向异性（尤其是相对较大的介电各向异性），其由式（1-1）所表示。例如，R1和R2为具有1-10个碳原子的烷基、具有2-10个碳原子的烯基或具有1-9个碳原子的烷氧基；环A1和环A2为1,4-苯撑、2-氟-1,4-苯撑、3-氟-1,4-苯撑或3,5-二氟-1,4-苯撑；m和n为0、1、2或3，且m和n的和为3。