It undergoes hydroxylation and N-acetylation, and the primary metabolites found in urine /of rats/ are 2,6-diacetylaminotoluene and 6-acetylamino-2-amino-3-hydroxytoluene.
... Resolution of the urine by reverse phase HPLC demonstrated the presence of four metabolites, but none of the parent 2,6-DAT. Therefore, the lack of carcinogenicity of 2,6-DAT /in rats/ is not due to lack of biotransformation in vivo. Following separation by HPLC, the metabolites were analyzed by electron impact and fast atom bombardment mass spectroscopy and by NMR spectroscopy. The metabolites were identified as a) 3-hydroxy-2,6-DAT, b) 4-hydroxy-2-acetylamino-6-aminotoluene, c) 2-acetylamino-6-aminotoluene, and d) 2,6-di(acetylamino)-toluene. ...
Male F344-rats were randomly assigned to treatment groups and given a single 10 milligram dose of carbon-14 tagged 2,6-diaminotoluene by gavage. ...Four unique metabolites of 2,6-diaminotoluene were identified in the 24 hour urine specimens by reverse phase HPLC. The metabolites, identified by spectroscopic data, were 3-hydroxy-2,6-diaminotoluene, 5-hydroxy-2-acetylamino-6-aminotoluene, 2-acetylamino-6-aminotoluene, and 2,6-di(acetylamino)-toluene; the latter two metabolites caused significant mutagenicity in the presence of S9 activation. ...
来源:Hazardous Substances Data Bank (HSDB)
毒理性
暴露途径
这种物质可以通过吸入、皮肤接触和摄入被身体吸收。
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
毒理性
吸入症状
蓝色嘴唇、手指甲和皮肤。咳嗽。头晕。头痛。呼吸急促。混乱。抽搐。恶心。失去意识。
Blue lips, fingernails and skin. Cough. Dizziness. Headache. Shortness of breath. Confusion. Convulsions. Nausea. Unconsciousness.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
毒理性
皮肤症状
红色。
Redness.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
毒理性
眼睛症状
红肿。疼痛。
Redness. Pain.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
毒理性
摄入症状
进一步参阅吸入部分。
Further see Inhalation.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
2,6-TDA is rapidly absorbed in the digestive tract. ... Rats given 10-milligram oral doses of (14)C-2,6-TDA eliminated 85% of the radioactivity in urine within 24 hours. No unmetabolized 2,6-TDA was found in the urine. After 6 days, 1% of the radioactivity could still be detected in tissues.
... 2,6-Diaminotoluene was rapidly and extensively absorbed following oral administration, indicating that its lack of carcinogenicity is not due to poor absorption from the gastrointestinal tract. 2,6-DAT was also rapidly excreted, with 85% of 2,6-DAT-associated radioactivity being recovered in the urine within 24 hr. ...
METHOD FOR PRODUCING CIS- AND TRANS-ENRICHED MDACH
申请人：BASF SE
公开号：US20170260115A1
公开（公告）日：2017-09-14
A process for preparing trans-enriched MDACH, including: distilling an MDACH starting mixture in the presence of an auxiliary, which is an organic compound having a molar mass of 62 to 500 g/mol, a boiling point at least 5° C. above the boiling point of cis,cis-2,6-diamino-1-methylcyclohexane, and 2 to 4 functional groups, each of which is independently an alcohol group or a primary, secondary or tertiary amino group. The MDACH starting mixture includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, based on the total amount of MDACH present in the MDACH starting mixture. The MDACH starting mixture includes both trans and cis isomers. Trans-enriched MDACH includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, where the proportion of trans isomers in the mixture is higher than the proportion of trans isomers in the MDACH starting mixture.
Diamine Compound Having Phosphorylcholine Group, Polymer Thereof, and Process for Producing the Polymer
申请人：Nagase Yu
公开号：US20100036081A1
公开（公告）日：2010-02-11
Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.
Compositions for oxidatively dyeing keratin fibers and methods for using such compositions
申请人：Lim Mu'Ill
公开号：US20070209123A1
公开（公告）日：2007-09-13
Compositions for dyeing keratin fibers comprise (a) at least one keratin dyeing compound selected from aromatic systems which comprise at least one boronic acid or boronic ester moiety and which are capable of forming upon oxidation a nucleophile or an electrophile, (b) at least one additional keratin dyeing compound selected from the group consisting of auxiliary developers and auxiliary couplers, and (c) a cosmetically suitable medium. Methods for oxidatively dyeing keratin fibers comprise the steps of applying such compositions in the presence of an oxidizing agent and rinsing the hair. A hair coloring product in kit form comprises a first separately packaged container comprising a composition as described above and a second separately packaged container comprising an oxidizing agent.
[EN] PROCESS FOR PREPARING ISOCYANATE COMPOUND<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ ISOCYANATE
申请人：BASF SE
公开号：WO2016177761A1
公开（公告）日：2016-11-10
The present invention relates to a process for the preparation of an isocyanate compound comprising the steps of: a) Reacting an amine compound A having at least one primary amino group with CO2 and an organotin compound S having at least one radical OR3 attached to the tin atom of the organotin compound, wherein R3 is a C-bound organic radical having from 1 to 30 carbon atoms, wherein 1, 2 or 3 carbon atoms may be replaced by oxygen or nitrogen, to convert at least one of the primary amino groups in the amine compound A into a carbamate group, thereby obtaining a carbamate compound C; b) cleavage of the carbamate groups in the carbamate compound C obtained in step a) to form the isocyanate compound and an alcohol R3OH, without separation of the tin compound formed in step a); c) obtaining the isocyanate compound from the reaction mixture of step b).
Synthesis of substituted quinolines by the electrophilic cyclization of n-(2-alkynyl)anilines
作者：Xiaoxia Zhang、Tuanli Yao、Marino A. Campo、Richard C. Larock
DOI：10.1016/j.tet.2009.12.012
日期：2010.2
A wide variety of substituted quinolines are readily synthesized under mild reaction conditions by the 6-endo-dig electrophilic cyclization of N-(2-alkynyl)anilines by ICl, I2, Br2, PhSeBr, and p-O2NC6H4SCl. The reaction affords 3-halogen-, selenium- and sulfur-containing quinolines in moderate to good yields in the presence of various functional groups. Analogous quinolines bearing a hydrogen in the
