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黄酮,5-氨基-6-羟基-(5CI) | 39909-28-9

中文名称
黄酮,5-氨基-6-羟基-(5CI)
中文别名
——
英文名称
2-(2-Aminopropyl)aniline
英文别名
——
黄酮,5-氨基-6-羟基-(5CI)化学式
CAS
39909-28-9
化学式
C9H14N2
mdl
MFCD08453763
分子量
150.22
InChiKey
YDAUEYCIHZEQIH-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.7
  • 重原子数:
    11
  • 可旋转键数:
    2
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.333
  • 拓扑面积:
    52
  • 氢给体数:
    2
  • 氢受体数:
    2

反应信息

  • 作为反应物:
    描述:
    参考文献:
    名称:
    KEMPTER G.; ZIEGNER H.-J.; MOSER G.; NATHO W., WISS. Z. PAED. HOCHSCH. K. LIEBKNECHT POTSDAM (TEIL 1), 1977, 21, NO 1, 5+
    摘要:
    DOI:
点击查看最新优质反应信息

文献信息

  • [EN] AMINOETHYLAROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR<br/>[FR] COMPOSES AMINOETHYLAROMATIQUES PERMETTANT DE TRAITER DES TROUBLES REPONDANT A UNE MODULATION DU RECEPTEUR D3 DE LA DOPAMINE
    申请人:ABBOTT GMBH & CO KG
    公开号:WO2006040179A1
    公开(公告)日:2006-04-20
    The present invention relates to aromatic compounds of the formula (I) wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry 1 or 2 radicals Rb; X is N or CH; E is CR6R7 or NR3; R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated Cl-C4­-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4­-alkenyl, formyl or C1-C3-alkylcarbonyl; R1a is H, C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-­C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3­-C4-alkenyl, or R1a and R2 together are (CH2)n with n being 2, 3 or 4, or R1a and R2a together are (CH2)n with n being 2, 3 or 4; R2 and R2a are independently of each other H, C1-C4-alkyl or fluorinated C1-C4-alkyl or R2a and R2 together are (CH2)m with m being 1, 2, 3, 4 or 5; R3 is H or C1-C4-alkyl; R6, R7 independently of each other are selected from H, fluorine, C1-C4-alkyl and fluorinated C1-C4-alkyl or together form a moiety (CH2)p with p being 2, 3, 4 or 5; and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula (I) or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.
    本发明涉及公式(I)的芳香族化合物,其中Ar为苯基或芳香族5-或6-成员C-键合杂环基,其中Ar可能携带1个基团Ra,Ar也可能携带1个或2个基团Rb;X为N或CH;E为CR6R7或NR3;R1为C1-C4-烷基,C3-C4-环烷基,C3-C4-环烷基甲基,C3-C4-烯基,代的Cl-C4-烷基,代的C3-C4-环烷基,代的C3-C4-环烷基甲基,代的C3-C4-烯基,甲酰基或C1-C3-烷基羰基;R1a为H,C1-C4-烷基,C3-C4-环烷基,C3-C4-环烷基甲基,C3-C4-烯基,代的C1-C4-烷基,代的C3-C4-环烷基,代的C3-C4-环烷基甲基,代的C3-C4-烯基,或R1a和R2一起为(CH2)n,其中n为2、3或4,或R1a和R2a一起为( )n,其中n为2、3或4;R2和R2a彼此独立为H,C1-C4-烷基或代的C1-C4-烷基,或R2a和R2一起为( )m,其中m为1、2、3、4或5;R3为H或C1-C4-烷基;R6、R7彼此独立地选自H、、C1-C4-烷基和代的C1-C4-烷基,或一起形成一个( )p的基团,其中p为2、3、4或5;以及其生理耐受的酸盐。该发明还涉及使用公式(I)的化合物或其药学上可接受的盐来制备用于治疗可用多巴胺D3受体配体治疗的医疗疾病的药物组合物。
  • Aminoethylaromatic Compounds Suitable For Treating Disorders That Respond To Modulation Of The Dopamine D3 Receptor
    申请人:Drescher Karla
    公开号:US20080096934A1
    公开(公告)日:2008-04-24
    The present invention relates to aromatic compounds of the formula I wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R a and wherein Ar may also carry 1 or 2 radicals R b ; X is N or CH; E is CR 6 R 7 or NR 3 ; R 1 is C 1 -C 4 -alkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -cycloalkylmethyl, C 3 -C 4 -alkenyl, fluorinated C 1 -C 4 -alkyl, fluorinated C 3 -C 4 -cycloalkyl, fluorinated C 3 -C 4 -cycloalkylmethyl, fluorinated C 3 -C 4 -alkenyl, formyl or C 1 -C 3 -alkylcarbonyl; R 1a is H, C 1 -C 4 -alkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -cycloalkylmethyl, C 3 -C 4 -alkenyl, fluorinated C 1 -C 4 -alkyl, fluorinated C 3 -C 4 -cycloalkyl, fluorinated C 3 -C 4 -cycloalkylmethyl, fluorinated C 3 -C 4 -alkenyl, or R 1a and R 2 together are (CH 2 ) n with n being 2, 3 or 4, or R 1a and R 2a together are (CH 2 ) n with n being 2, 3 or 4; R 2 and R 2a are are independently of each other H, C 1 -C 4 -alkyl or fluorinated C 1 -C 4 -alkyl or R 2a and R 2 together are (CH 2 ) m with m being 1, 2, 3, 4 or 5; R 3 is H or C 1 -C 4 -alkyl; R 6 , R 7 independently of each other are selected from H, fluorine, C 1 -C 4 -alkyl and fluorinated C 1 -C 4 -alkyl or together form a moiety (CH 2 ) p with p being 2, 3, 4 or 5; and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.
    本发明涉及式I的芳香族化合物,其中Ar是苯基或芳香族5-或6-成员C-连接的杂环基,其中Ar可以携带1个基团Ra,且Ar还可以携带1或2个基团Rb;X是N或CH;E是CR6R7或NR3;R1是C1-C4烷基、C3-C4环烷基、C3-C4环烷基甲基、C3-C4烯基、代C1-C4烷基、代C3-C4环烷基、代C3-C4环烷基甲基、代C3-C4烯基、甲酰基或C1-C3烷基羰基;R1a是H、C1-C4烷基、C3-C4环烷基、C3-C4环烷基甲基、C3-C4烯基、代C1-C4烷基、代C3-C4环烷基、代C3-C4环烷基甲基、代C3-C4烯基,或R1a和R2一起是(CH2)n,其中n为2、3或4,或R1a和R2a一起是( )n,其中n为2、3或4;R2和R2a彼此独立地是H、C1-C4烷基或代C1-C4烷基,或者R2a和R2一起是( )m,其中m为1、2、3、4或5;R3是H或C1-C4烷基;R6、R7彼此独立地选择自H、、C1-C4烷基和代C1-C4烷基,或者一起形成( )p的基团,其中p为2、3、4或5;以及其生理耐受性酸盐。本发明还涉及使用式I的化合物或其药学上可接受的盐制备用于治疗易受多巴胺D3受体配体治疗的医疗疾病的制药组合物。
  • AMINOETHYLAROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR
    申请人:Drescher Karla
    公开号:US20120220635A1
    公开(公告)日:2012-08-30
    The present invention relates to aromatic compounds of the formula (I) and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula (I) or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D 3 receptor ligand.
    本发明涉及公式(I)的芳香族化合物及其生理耐受的酸加成盐。本发明还涉及使用公式(I)的化合物或其药学上可接受的盐来制备用于治疗易于用多巴胺D3受体配体治疗的医疗障碍的制药组合物。
  • Aminoethylaromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
    申请人:Abbott GmbH & Co. KG
    公开号:EP2371814A1
    公开(公告)日:2011-10-05
    The present invention relates to aromatic compounds of the formula I wherein the variables have the definitions given in the claims and description. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.
    本发明涉及式 I 的芳香族化合物 其中的变量具有权利要求和说明中给出的定义。 本发明还涉及使用式 I 的化合物或其药学上可接受的盐制备药物组合物,用于治疗易受多巴胺 D3 受体配体治疗的疾病。
  • US8232426B2
    申请人:——
    公开号:US8232426B2
    公开(公告)日:2012-07-31
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同类化合物

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