视黄基维甲酸酯 | 15498-86-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 视黄基维甲酸酯
• 英文名称: Retinyl retinoate
• 英文别名: retin-15-yl ester retinoic acid；retinyl retionate；[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
• CAS: 15498-86-9
• 化学式: C₄₀H₅₆O₂
• 分子量: 568.883
• InChiKey: QNCTWCFXYGJGKU-CHOOPKNISA-N

物化性质

• 沸点：
  671.0±24.0 °C(Predicted)
• 密度：
  0.980±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、乙酸乙酯（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  42
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 储存条件：
  -20°C

反应信息

• 作为产物：
  描述：

  维A酸 、 维生素A 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以78%的产率得到视黄基维甲酸酯
  参考文献：
  名称：

  Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative

  摘要：

  A new hybrid, retinyl retinoate 1, was synthesized with a condensing reaction between retinol and retinoic acid to improve the photo-stability, and the in vitro biological activity of the hybrid was analyzed. This retinol derivative had enhanced thermal stability and decreased photosensitivity, and exhibited decreased cell toxicity compared to that of retinol. In addition, RAR activity analysis showed that retinyl retinoate 1 had higher inhibitory activity against c-Jun than retinol and showed superior effects on collagen synthesis compared to retinol. Thus, retinyl retinoate 1 may have the potential to be conveniently used as an additive in cosmetics for prevention and improvement of skin aging and medicines for the treatment of skin troubles due to its excellent stability under severe and accelerated conditions. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.05.005

文献信息

• [EN] RETINOID DERIVATIVES AND PROCESS FOR THEIR PREPARATION<br/>[FR] DÉRIVÉS RÉTINOÏDES ET PROCÉDÉ POUR LES PRÉPARER
  申请人：SELEGO AB

  公开号：WO2014204390A1

  公开（公告）日：2014-12-24

  Novel retinoic acid derivatives and a process for their preparation are described.

  描述了一种新型的维甲酸衍生物及其制备方法。
• Retinol derivatives and process for preparing same
  申请人：——

  公开号：US20040062781A1

  公开（公告）日：2004-04-01

  The present invention relates to a new retinyl retinoate, a process for preparing same, a new intermediate which is useful for preparing same, and a cosmetic composition comprising the retinyl retinoate as the active ingredient.

  本发明涉及一种新的视黄醇酯基维甲酸酯、其制备方法、一种用于制备该化合物的新中间体以及一种含有该视黄醇酯基维甲酸酯作为活性成分的化妆品组合物。
• RETINOID DERIVATIVES AND PROCESS FOR THEIR PREPARATION
  申请人：SELEGO AB

  公开号：US20160136076A1

  公开（公告）日：2016-05-19

  Novel retinoic acid derivatives and a process for their preparation are described.

  本发明涉及新型维甲酸衍生物及其制备方法。
• A nanofibrillar cellulose product and a method for manufacturing thereof
  申请人：UPM-Kymmene Corporation

  公开号：US20210130500A1

  公开（公告）日：2021-05-06

  The present application provides a method for preparing nanofibrillar cellulose product, the method comprising providing nanofibrillar cellulose, providing multivalent cations, contacting the nanofibrillar cellulose with the multivalent cations, and allowing reacting for a period of time to obtain cross-linked nanofibrillar cellulose product. The present application also provides a nanofibrillar cellulose product comprising nanofibrillar cellulose and multivalent cations, wherein the nanofibrillar cellulose is crosslinked by the multivalent cations.

  本申请提供了一种制备纳米纤维素产品的方法，该方法包括提供纳米纤维素，提供多价阳离子，将纳米纤维素与多价阳离子接触，并允许反应一段时间以获得交联的纳米纤维素产品。本申请还提供了一种纳米纤维素产品，包括纳米纤维素和多价阳离子，其中纳米纤维素通过多价阳离子交联。
• COMPOSITION FOR EXTERNAL USE
  申请人：ROHTO PHARMACEUTICAL CO., LTD.

  公开号：EP1849481A1

  公开（公告）日：2007-10-31

  An object of the present invention is to provide a composition for external use in which the percutaneous absorbability of vitamin A, vitamin A derivative(s), vitamin C, specific vitamin C derivative(s), xanthine derivative(s), ubiquinone(s) and/or hyaluronic acid is improved. The composition for external use is prepared by blending (i) a phospholipid and (ii) a mono- or oligo-glycol ether, together with (iv) at least one bioactive component selected from the group consisting of hyaluronic acid, hyaluronic acid derivatives, vitamin A, vitamin A derivatives, vitamin C, specific vitamin C derivatives, xanthine derivatives, ubiquinones, and salts thereof.

  本发明的目的是提供一种外用组合物，其中维生素 A、维生素 A 衍生物、维生素 C、特定维生素 C 衍生物、黄嘌呤衍生物、泛素酮和/或透明质酸的经皮吸收性得到改善。 外用组合物的制备方法是将(i)磷脂和(ii)单-或寡-乙二醇醚与(iv)至少一种生物活性成分混合在一起，这些生物活性成分选自透明质酸、透明质酸衍生物、维生素 A、维生素 A 衍生物、维生素 C、特定维生素 C 衍生物、黄嘌呤衍生物、泛醌及其盐类组成的组。