代谢
研究了酶诱导对双(2-甲氧基乙基)醚(二甘醇)在大鼠代谢的影响。雄性Sprague-Dawley大鼠连续22天通过饮水给予5.1 mmol/kg二甘醇或0.1%苯巴比妥。其他大鼠先通过饮水连续22天给予5.1 mmol/kg二甘醇或0.1%苯巴比妥预处理，然后单次口服给予5.1 mmol/kg (14)C标记的二甘醇。在给药后6至96小时收集尿液样本并分析二甘醇代谢物。苯巴比妥和二甘醇显著减少了戊巴比妥睡眠时间，其中苯巴比妥效果更明显。苯巴比妥或二甘醇预处理并没有显著影响(14)C活性的累积排泄。苯巴比妥和二甘醇都显著增加了甲氧基乙酸的累积排泄量，其中苯巴比妥效果更明显。/研究结论是/，用二甘醇或苯巴比妥预处理大鼠增加了二甘醇中醚键断裂的程度，形成了2-甲氧基乙醇，这是甲氧基乙酸的先驱物，一种可能的生殖毒性物质。
The effect of enzyme induction on the metabolism of bis(2-methoxyethyl)ether (diglyme) was studied in rats. Male Sprague-Dawley rats were administered 5.1 mmol/kg diglyme or 0.1% phenobarbital in their drinking water for 22 days. Other rats were pretreated with 5.1 mmol/kg diglyme or 0.1% phenobarbital administered in their drinking water for 22 days, and then given a single oral dose of 5.1 mmol/kg (14)C labeled diglyme. Urine samples were collected at 6 to 96 hours post dosing and analyzed for diglyme metabolites. Phenobarbital and diglyme caused significant decreases in hexobarbital sleeping time, phenobarbital showing the greater effect. Pretreatment with phenobarbital or diglyme did not significantly affect cumulative excretion of (14)C activity. Cumulative excretion of methoxyacetic acid, a minor metabolite, was significantly increased by both phenobarbital and diglyme, phenobarbital showing the greater effect. /It was concluded/ that pretreating rats with diglyme or phenobarbital increases the extent of cleavage of the ether bond in diglyme, forming 2-methoxyethanol, a precursor of methoxyacetic acid, a putative reproductive toxicant.
来源:Hazardous Substances Data Bank (HSDB)
