去氢莪术二酮 | 38230-32-9

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 去氢莪术二酮
• 英文名称: dehydrocurdione
• 英文别名: (6E,10S)-6,10-dimethyl-3-propan-2-ylidenecyclodec-6-ene-1,4-dione
• CAS: 38230-32-9
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: ZYPUZCWWTYIGFV-BCMYLCSRSA-N

物化性质

• LogP：
  2.433 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 储存条件：
  -20°C密封保存，干燥避光。

制备方法与用途

脱氢卡脲是一种从莪术中衍生出的倍半萜，能在原始264.7巨噬细胞中诱导血红素加氧酶(HO)-1的表达，这是一种抗氧化酶。脱氢卡脲通过与Keap1相互作用，促使Nrf2易位并激活HO-1 E2增强子。此外，它还能抑制脂多糖诱导的一氧化氮(NO)释放，而一氧化氮是炎症的一个标志物。因此，脱氢卡脲具有显著的抗炎活性。

反应信息

• 作为反应物：
  描述：

  去氢莪术二酮 在 aluminum oxide 作用下， 以 苯 为溶剂， 以87%的产率得到莪术醇
  参考文献：
  名称：

  脱氢姜二酮向姜黄素和异姜黄素的仿生转化及其立体化学

  摘要：

  从中分离出的倍半萜烯脱氢姜二酮以高度选择性的方式转化为姜黄烯醇，异姜黄烯醇或新的螺内酯，并确定了它们的绝对构型。

  DOI：

  10.1016/s0040-4039(00)61963-9

文献信息

• Transdermal delivery of pharmaceutical agents
  申请人：Russell-Jones J. Gregory

  公开号：US20070243132A1

  公开（公告）日：2007-10-18

  The present invention generally relates to a vehicle useful for delivering a pharmaceutically active compound including a genetic molecule or composition. More particularly, the present invention provides microemulsions for transdermal delivery of pharmaceutically active agents to a subject.

  本发明通常涉及一种用于传递包括遗传分子或组成的药物活性化合物的车辆。更具体地，本发明提供了微乳液，用于经皮途径向受体传递药物活性剂。
• Curcumol derivatives, the compositions containing the said derivatives, and the use of the same in the manufacture of medicaments
  申请人：Wang Shulong

  公开号：US20070191360A1

  公开（公告）日：2007-08-16

  The present invention provides curcumol derivatives of the following formula (I) or pharmaceutical acceptable salts thereof: wherein, Y is selected from the group consisting of ═CHR 2 , —CH 2 R 2 , ═O, —OH or —OR 1 ;R 1 is selected from H, R, RCO or HO 3 S; and R is selected from the group consisting of H; saturated or unsaturated linear C 1-10 hydrocarbon group and the like; R 2 is selected from the group consisting of F; Cl; Br; I; H; —OH; —OR; —HSO 3 and the like; with the proviso that both R 1 and R 2 are not H. The present invention also provides anti-tumor or antiviral pharmaceutical compositions comprising said derivatives or pharmaceutical acceptable salts thereof. The present invention further provides the use of said derivatives or pharmeceutical acceptable salts thereof in the preparation of a medicament for prophylaxis and/or treatment tumor or an antiviral medicament.

  本发明提供以下式（I）的姜黄醇衍生物或其药学上可接受的盐：其中，Y选自 ═CHR2，—CH2R2，═O，—OH或—OR1的群组；R1选自H，R，RCO或HO3S；R选自H；饱和或不饱和的线性C1-10烃基等群组；R2选自F，Cl，Br，I，H，—OH，—OR，—HSO3等群组；但要求R1和R2均不为H。本发明还提供包含上述衍生物或其药学上可接受的盐的抗肿瘤或抗病毒药物组合物。本发明还提供使用上述衍生物或其药学上可接受的盐制备预防和/或治疗肿瘤或抗病毒药物的药物。
• Permeation enhancer comprising genus Curcuma or germacrone for transdermal and topical administration of active agents
  申请人：Carrara Dario Norberto R.

  公开号：US20050244522A1

  公开（公告）日：2005-11-03

  A formulation, method and system for the topical, transdermal or transmucosal administration of a therapeutically effective active agent. Particularly, the invention provides a formulation, system and method for enhancing the permeation or penetration of active agents across the dermal or mucosal surfaces of a mammalian subject. The formulation includes a plant extract of the genus Curcuma of the family Zingiberaceae, a germacrone, or a natural or synthetic constituent thereof, which has been found to increase penetration of the active agent across the dermal or mucosal surface. If desired, a secondary permeation enhancer of a polyalcohol, a monoalkyl ether of diethylene glycol, a tetraglycol, or a mixture thereof can be used for certain active agents for optimal permeation enhancement.

  一种用于局部、透皮或透粘膜给药治疗有效活性剂的制剂、方法和系统。特别是，本发明提供了一种配方、系统和方法，用于增强活性剂在哺乳动物皮肤或粘膜表面的渗透或穿透。制剂包括姜黄属植物提取物 莪术 莪术属植物提取物、一种莪术酮或其天然或合成成分，它们已被证实可增加活性剂在皮肤或粘膜表面的渗透。如果需要，某些活性剂还可以使用多元醇、二甘醇单烷基醚、四甘醇或它们的混合物作为二级渗透促进剂，以达到最佳的渗透增强效果。
• Topical formulations and methods of use
  申请人：Morariu Marius

  公开号：US20060216251A1

  公开（公告）日：2006-09-28

  A topical composition comprising a lipoic acid, a carnitine, and a carnosine in a suitable vehicle for topical application and a method for treating skin is provided. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles and loss of elasticity. Preferred components include R-lipoic acid or R-dihydrolipoic acid, acetyl-1-carnitine, and 1-carnosine.

  本发明提供了一种外用组合物，该组合物包含硫辛酸、肉毒碱和肉毒碱，并以适合外用的载体形式存在，还提供了一种治疗皮肤的方法。本组合物有助于改善以皱纹和失去弹性为特征的老化皮肤的外观。优选成分包括 R-硫辛酸或 R-二氢硫辛酸、乙酰基-1-肉碱和 1-肉碱。
• CURCUMOL DERIVATIVES, THE COMPOSITIONS COMPRISING THE SAME AND THE USE OF THE SAME IN THE MANUFACTURE OF MEDICAMENT
  申请人：Hangzhou Minsheng Pharmaceuticals Co., Ltd.

  公开号：EP1749830B1

  公开（公告）日：2013-12-11