柳杉二醇11-鼠李糖苷 | 349112-30-7

• 物质功能分类: 天然产物 - 倍半萜
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 柳杉二醇11-鼠李糖苷
• 英文名称: Cryptomeridiol 11-α-L-rhamnoside
• 英文别名: CryptoMeridiol 11-rhaMnoside；(2S,3R,4R,5R,6S)-2-[2-[(2R,4aR,8R,8aR)-8-hydroxy-4a,8-dimethyl-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]propan-2-yloxy]-6-methyloxane-3,4,5-triol
• CAS: 349112-30-7
• 化学式: C₂₁H₃₈O₆
• 分子量: 386.529
• InChiKey: HUSBLOAZNQURFJ-YOYCCLINSA-N

物化性质

• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 柳杉二醇11-鼠李糖苷 在 吡啶 作用下， 生成 Cryptomeridiol 11-α-L-rhamnoside triacetate
  参考文献：
  名称：

  Cytotoxic Constituents of the Fruits of Cananga odorata

  摘要：

  A new guaipyridine sesquiterpene alkaloid, cananodine (1), and two new eudesmane sesquiterpines, cryptomeridiol 11-alpha -L-rhamnoside (2) and gamma -eudesmol 11-alpha -L-rhamnoside (3), along with gamma -eudesmol (4), were isolated from the fruits of Cananga odorata. The structures of compounds 1-3 were established on the basis of NMR and MS methods. In addition, compounds 1-4 and four previously reported alkaloids, cleistopholine (5), N-trans-feruloyltyramine (8), (+)-ushinsunine-beta -N-oxide (7), and lyscamine (8), were evaluated for cytotoxicity against two human hepatocarcinoma cell lines.

  DOI：

  10.1021/np0005208