(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate | 52225-20-4

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate
• 英文别名: (2R,4'RS,8'RS)-α-tocopheryl acetate；DL α-tocopheryl acetate；DL-alpha-tocopherol acetate；vitamin E；(+)-α-tocopherol acetate；dl-α-tocopheryl acetate；d-Vitamin E acetate；[(2R)-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] acetate
• CAS: 52225-20-4；7695-91-2
• 化学式: C₃₁H₅₂O₃
• 分子量: 472.752
• InChiKey: ZAKOWWREFLAJOT-PDNQPUDYSA-N

物化性质

• 熔点：
  -27.5°
• 沸点：
  bp0.01 184°; bp0.025 194°; bp0.3 224°
• 密度：
  0.96 g/mL at 20 °C(lit.)
• 闪点：
  9℃
• 溶解度：
  可溶于氯仿、乙醇（少量）、甲醇（少量）

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• WGK Germany：
  1
• 海关编码：
  29362800
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

生物活性

DL-α-生育酚醋酸酯是维生素E的衍生物，常被用于肠内营养中。

体内研究

DL-α-生育酚醋酸酯（α-TA）能增加肝脏、大脑、睾丸和心脏等组织中的胆固醇水平。在调整蛋白质含量后，大脑中的胆固醇水平明显高于其他组织。此外，DL-α-生育酚醋酸酯还能提高小鼠肝、脑和睾丸中脂质过氧化水平。

反应信息

• 作为产物：
  描述：

  (-)-(S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-carboxylic acid methyl ester 在 palladium on activated charcoal 吡啶 、 氢气 、 sodium methylate 、 二异丁基氢化铝 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 、 甲苯 为溶剂， -70.0~25.0 ℃ 、101.33 kPa 条件下， 反应 61.5h， 生成 (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate
  参考文献：
  名称：

  乙酸α-生育酚酯的所有八种立体异构体的全合成。通过气相色谱法测定其非对映异构体和对映异构体的纯度†

  摘要：

  乙酸α-生育酚酯的所有八种立体异构体均以高化学和立体异构体纯度的状态合成。由（+）-（S）-3-羟基-2-甲基丙酸制备关键的手性侧链中间体。到新的路线（2 - [R，4' RS，8' RS）-α生育酚乙酸酯，四个非对映异构的混合物，也被开发的。开发了一种灵敏的气相色谱方法来测定α-生育酚样品作为甲基醚的非对映异构和对映异构纯度。首次确定天然存在的α-生育酚本质上是单一对映体（2 R，4'R，8'R），合成的全外消旋-α-生育酚是四个外消旋物的等摩尔混合物，而天然（E）-（7 R，11 R）-植物醇是非对映异构体和对映异构体均质的。

  DOI：

  10.1002/hlca.19810640422

文献信息

• Lyotropic Liquid Crystal Coated Analyte Monitoring Device and Methods of Use
  申请人：Heller Adam

  公开号：US20080177164A1

  公开（公告）日：2008-07-24

  The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.
• MULTIFUNCTIONAL OPTICAL SENSOR
  申请人：Broer Dirk J.

  公开号：US20120033173A1

  公开（公告）日：2012-02-09

  The invention relates to a multifunctional optical sensor, having at least 2 areas which independently react to different input parameters, the sensor comprising a substrate and a polymeric layer comprising polymerized liquid crystal monomers having an ordered morphology, wherein the color, the reflectivity or the birefringence of the sensor changes due to a change of the morphology, wherein said change of the morphology is caused by physical contact with a chemical agent such as a gas or liquid a change of temperature, or passage of time. The invention also relates to a process for the preparation of the sensor and for the use of a film comprising a single substrate, a layer having a cholesteric liquid crystalline structure for application in labels for packaging of perishable goods, food, fine chemicals, bio-medical materials.
• Compounds, Compositions, And Methods For Reducing Or Eliminating Bitter Taste
  申请人：Hayashi David

  公开号：US20130096209A1

  公开（公告）日：2013-04-18

  The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
• COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTER TASTE
  申请人：CHROMOCELL CORPORATION

  公开号：US20150237900A1

  公开（公告）日：2015-08-27

  The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
• US8255034B2
  申请人：——

  公开号：US8255034B2

  公开（公告）日：2012-08-28