(3aR^*,4S^*,5R^*,7S^*,7aR^*)-2,3,3a,4,5,6,7,7a-octahydro-5-hydroxy-4,7-methano-1H-indene | 10271-45-1

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3aR^*,4S^*,5R^*,7S^*,7aR^*)-2,3,3a,4,5,6,7,7a-octahydro-5-hydroxy-4,7-methano-1H-indene
• 英文别名: endo-5,6-Trimethylene-exo-2-norbornanol；endo-tricyclo<5.2.1.0^2,6>decan-exo-8-ol；(3aRS,4SR,5RS,7SR,7aRS)-(±)-octahydro-1H-4,7-methanoinden-5-ol；Octahydro-endo-4,7-methanoinden-exo-5-ol；(+/-)-5c-hydroxy-(3arH,7acH)-hexahydro-4c,7c-methano-indan；(3aα,4α,5α,7α,7aα)-octahydro-4,7-methano-1H-inden-5-ol；endo-5,6-Trimethylen-exo-2-norbornanol；endo-5,6-Trimethylen-exo-2-norborneol；(3aalpha,4alpha,5alpha,7alpha,7aalpha)-Octahydro-4,7-methano-1H-inden-5-ol；(1S,2R,6R,7S,8R)-tricyclo[5.2.1.02,6]decan-8-ol
• CAS: 10271-45-1
• 化学式: C₁₀H₁₆O
• 分子量: 152.236
• InChiKey: FKZJBAXKHJIQDU-LOLPMWEVSA-N

物化性质

• 沸点：
  255.2±8.0 °C(Predicted)
• 密度：
  1.115±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906199090

反应信息

• 作为反应物：
  描述：

  (3aR^*,4S^*,5R^*,7S^*,7aR^*)-2,3,3a,4,5,6,7,7a-octahydro-5-hydroxy-4,7-methano-1H-indene 生成 (3aR^*,4S^*,7R^*,7aS^*)-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene
  参考文献：
  名称：

  Rearrangements of dihydrodicyclopentadiene derivatives in phosphoric acid. 1,4-Hydride shifts

  摘要：

  DOI：

  10.1021/ja00732a048
• 作为产物：
  描述：

  (3aR^*,4S^*,7R^*,7aS^*)-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene 生成 (3aR^*,4S^*,5R^*,7S^*,7aR^*)-2,3,3a,4,5,6,7,7a-octahydro-5-hydroxy-4,7-methano-1H-indene
  参考文献：
  名称：

  Bridged Polycyclic Compounds. X. The Synthesis of endo and exo-1,2-Dihydrodicyclopentadienes and Related Compounds¹

  摘要：

  DOI：

  10.1021/ja01494a060

文献信息

• Ethnopsychological Method and the Psychological Assessment of Mexican Americans
  作者：Guadalupe Gutierrez

  DOI：10.1177/0739986302024003001

  日期：2002.8

  This article reviews the theoretical and methodological development of ethnopsychology, which is founded on the principle that distinct cultural groups share basic common beliefs and values that differentiate them psychologically from other cultural groups. The distinctness of a cultural group is rooted in a series of historical, sociocultural experiences and perceptions of oneself and the group as a whole. The development of ethnopsychology is summarized through the contributions of Rogelio Diaz-Guerrero and his early exploration of the fundamental premises and tenets that guide ethnopsychological theory and method. The contributions of other theorists, focusing on the uniqueness of bicultural/bilingual groups such as Mexican Americans, are also summarized. The author supports the application of ethnopsychological theory and method to enhance psychologists’ understanding of bilingual/bicultural groups in the United States. Specifically, she reviews current psychological assessment methods and their ethnopsychological adaptation for Mexican Americans.

  本文回顾了民族心理学的理论和方法论发展，该学科基于这样一个原则：不同文化群体共享基本的共同信仰和价值观，这些共同点在心理上将他们与其他文化群体区分开来。文化群体的独特性根植于一系列历史、社会文化经验以及个人和整个群体对自己的认知。民族心理学的发展通过Rogelio Diaz-Guerrero的贡献进行了总结，他早期探索了指导民族心理学理论和方法的基本前提和原则。还总结了其他理论家的贡献，重点关注了墨西哥裔美国人等双文化/双语群体的独特性。作者支持将民族心理学理论和方法应用于增进心理学家对美国双文化/双语群体的理解。具体来说，她回顾了当前的心理评估方法及其在墨西哥裔美国人中的民族心理学适应性。
• Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors
  作者：Michal Šála、Armando M. De Palma、Hubert Hřebabecký、Radim Nencka、Martin Dračínský、Pieter Leyssen、Johan Neyts、Antonín Holý

  DOI：10.1016/j.bmc.2010.04.081

  日期：2010.6

  (CVB3) inhibitors are reported. These compounds could be considered as the 6-chloropurines substituted at position 9 with variously substituted bicyclic scaffolds (bicyclo[2.2.1]heptane/ene—norbornane or norbornene). The synthesis and biological evaluation of 31 target compounds are described. Several of the analogues inhibited CVB3 in the low micromolar range (0.66–2 μM). Minimal or no cytotoxicity was

  报道了新型的柯萨奇病毒B3（CVB3）抑制剂的合成和SAR研究。这些化合物可视为在9位被各种取代的双环支架（双环[2.2.1]庚烷/烯-降冰片烷或降冰片烯）取代的6-氯嘌呤。描述了31种目标化合物的合成和生物学评估。几种类似物在低微摩尔范围（0.66–2μM）中抑制CVB3。观察到最小或没有细胞毒性。
• What Is the True Structure of D609, a Widely Used Lipid Related Enzyme Inhibitor?
  作者：Mikako Kato、Mostafa A. S. Hammam、Tohru Taniguchi、Yoshiko Suga、Kenji Monde

  DOI：10.1021/acs.orglett.6b00025

  日期：2016.2.19

  eight possible stereoisomers, no systematic research considering its chirality has been performed. In this paper, eight possible chiral alcohols as direct precursors of D609 were synthesized, and their stereochemistries were elucidated by a vibrational circular dichroism (VCD) technique. Phosphatidylcholine-specific phospholipase C and sphingomyelin synthase inhibition assays of these isomers showed

  在过去的三十年中，D609（1）被用作脂质相关的酶抑制剂。尽管它具有八种可能的立体异构体，但尚未进行有关其手性的系统研究。本文合成了八种可能的手性醇作为D609的直接前体，并通过振动圆二色性（VCD）技术阐明了它们的立体化学。这些异构体的磷脂酰胆碱特异性磷脂酶C和鞘磷脂合酶抑制试验表明，它们的活性存在相当大的差异。
• Linearly fused vs bridged regioselection in the intramolecular 1,3-diyl trapping reaction
  作者：Mohammad R. Masjedizadeh、Ingeborg Dannecker-Doerig、R. Daniel Little

  DOI：10.1021/jo00296a035

  日期：1990.4
• Ion-Molecule Complexes in 1,2-Alkyl Shifts
  作者：Andrea Gappa、Ekkehard Herpers、Roland Herrmann、Volker Huelsewede、Wilhelm Kappert、Matthias Klar、Wolfgang Kirmse

  DOI：10.1021/ja00154a010

  日期：1995.12

  The internal return of neutral leaving groups was studied in rearrangements of polycyclic systems (2-norpinyl --> 2-norbornyl, endo- --> exo-tricyclo[5.2.1.0(2,6)]dec-8-yl, bicyclo[3.2.0]hept-2-yl --> 7-norbornyl, and 4-protoadamantyl --> 2-adamantyl). Acid catalysis was applied to O-18-labeled alcohols in aqueous organic solvents, to alcohols in methanol, and to ethers R-O-R' in alcohols R''-OH. The leaving group was found to attack the migration origin in competition with solvent molecules, Return:exchange ratios were obtained from product distributions, either directly or by kinetic simulation (in cases of partial exchange prior to rearrangement). If departure and return of the leaving group occur on the same side of the carbon framework, return:exchange ratios ranging from 1 to 11.5 were observed. Less internal return was found for bridged than for open carbocations, Migration of the departing molecule to the opposite face (exo reversible arrow endo) or to a beta carbon is a minor process (return:exchange 0.1), in accordance with previous reports on inverting displacements and allylic 1,3 shifts. These data are rationalized in terms of short-lived ion-molecule (ion-dipole) complexes whose collapse competes with ligand exchange.