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pactamycate | 23754-55-4

中文名称
——
中文别名
——
英文名称
pactamycate
英文别名
Pactamycat;2-hydroxy-6-methyl-benzoic acid (4S,5R)-8t-(3-acetyl-anilino)-9c-amino-6t,7-dihydroxy-4,6c-dimethyl-2-oxo-(5rN)-3-oxa-1-aza-spiro[4.4]non-7t-ylmethyl ester;[(4S,5R,6S,7S,8S,9R)-7-(3-acetylanilino)-6-amino-8,9-dihydroxy-4,9-dimethyl-2-oxo-3-oxa-1-azaspiro[4.4]nonan-8-yl]methyl 2-hydroxy-6-methylbenzoate
pactamycate化学式
CAS
23754-55-4
化学式
C26H31N3O8
mdl
——
分子量
513.547
InChiKey
GRYVVIDCTCRLJM-FIGCJUEWSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    770.2±60.0 °C(Predicted)
  • 密度:
    1.44±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    1.2
  • 重原子数:
    37
  • 可旋转键数:
    7
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.42
  • 拓扑面积:
    180
  • 氢给体数:
    6
  • 氢受体数:
    10

SDS

SDS:20fc38047f693d134313e79bd16d5d4b
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上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

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文献信息

  • Structure of pactamycin
    作者:Paul F. Wiley、Heinz K. Jahnke、Forrest A. MacKellar、Ronald Burger Kelly、Alexander D. Argoudelis
    DOI:10.1021/jo00830a035
    日期:1970.5
  • PACTAMYCIN BIOSYNTHETIC GENE CLUSTER
    申请人:Mahmud Taifo
    公开号:US20100210837A1
    公开(公告)日:2010-08-19
    This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin.
  • PACTAMYCIN ANALOGS AND METHODS OF MAKING THEREOF
    申请人:Oregon State University
    公开号:US20150183730A1
    公开(公告)日:2015-07-02
    This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin. The present disclosure also relates to the use of the pactamycin biosynthetic genes located within the identified gene cluster for drug design and development purposes, including the development of pactamycin analogs that are more efficacious and less toxic. Also provided are drugs and antibiotics so produced, as well as methods of their use.
  • US8957251B2
    申请人:——
    公开号:US8957251B2
    公开(公告)日:2015-02-17
  • [EN] PACTAMYCIN BIOSYNTHETIC GENE CLUSTER<br/>[FR] AGRÉGAT DE GÈNE BIOSYNTHÉTIQUE DE PACTAMYCINE
    申请人:OREGON STATE
    公开号:WO2008131258A2
    公开(公告)日:2008-10-30
    [EN] This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin.
    [FR] L'invention concerne le clonage moléculaire d'un agrégat de gène biosynthétique de pactamycine de streptomyces pactum ATCC 27456, la caractérisation de gènes individuels de l'agrégat de gène et les protéines ainsi codées aussi bien que leurs utilisations. L'agrégat de gène de pactamycine est situé dans un locus génétique de 86,35 kilobases et comprend 53 phases de lecture ouvertes, 26 d'entre elles sont considérées pour être l'agrégat de noyau directement impliqué dans la biosynthèse de pactamycine.
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