delphinine | 561-07-9

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 芳香烃
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: delphinine
• 英文别名: [(1S,2R,3R,4R,5S,6S,8R,9R,13S,16S,17R,18R)-8-acetyloxy-5-hydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate
• CAS: 561-07-9
• 化学式: C₃₃H₄₅NO₉
• 分子量: 599.722
• InChiKey: REVYTWNGZDPRKE-UWZYQZSNSA-N

物化性质

• 熔点：
  197.5-199°
• 比旋光度：
  D20 +25° (ethanol)
• 沸点：
  650.15°C (rough estimate)
• 密度：
  1.1925 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  10

ADMET

毒理性

• 毒性总结

Delphinine 作为电压门控钠通道的变构调节剂。（L1234）

Delphinine acts as an allosteric modulator of voltage-gated sodium channels. (L1234)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

海豚素是心脏毒素。（L1234）

Delphinine is cardiotoxic. (L1234)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（摄入）（L1817）；皮肤（L1817）

Oral (ingestion) (L1817) ; dermal (L1817)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

Delphinine导致低血压、心动过缓和心律不齐。

Delphinine causes hypotension, bradycardia and cardiac arrythmia. (L1234)

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为反应物：
  描述：

  delphinine 在 氢氧化钾 作用下， 生成 Delphonine
  参考文献：
  名称：

  Pelletier, S. William; Ross, Samir A., Heterocycles, 1990, vol. 31, # 4, p. 671 - 675

  摘要：

  DOI：

文献信息

• NEW USE FOR A COMPOUND AS A MATRIX IN THE SPECIFIC DETECTION, IDENTIFICATION AND/OR QUANTIFICATION OF ALKALOIDS BY MALDI-TOF MASS SPECTROMETRY
  申请人：Dias Marylène

  公开号：US20140319331A1

  公开（公告）日：2014-10-30

  There is provided (i) a method of analysing small molecules that may have a mass of <800 Da, in particular alkaloids, said method being generally referred to as MALDI-TOF-MS (or MALDI time-of-flight mass spectrometry), which is an acronym for a method of analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Also provided is (ii) a molecule according to formula (I) and the use of the molecule as a matrix in the analysis method.

  提供了一种分析可能具有质量小于800 Da的小分子的方法，特别是生物碱，该方法通常被称为MALDI-TOF-MS（或MALDI飞行时间质谱），这是一种通过基质辅助激光解吸/电离飞行时间质谱分析的方法的首字母缩写。还提供了一种根据式（I）的分子以及将该分子用作分析方法中的基质的用途。
• Method of detecting viable cells
  申请人：FUJI ELECTRIC HOLDINGS CO., LTD.

  公开号：EP1624071A2

  公开（公告）日：2006-02-08

  An object of the represent invention is to provide a method of detecting viable cells that can detect and quantify viable cells in a sample quickly, readily, and accurately. The reagents used in the method are safe, stable in storage, and inexpensive. The method comprises steps (1), (2) and (3). In the step (1), the cells are fluorescently stained by adding a fluorescent dye into the sample or making the sample in contact with the fluorescent dye. In the step (2), a quenching dye is added to the sample stained with the fluorescent dye, or the sample is made in contact with the quenching dye, under a condition of a pH value that is different from the pH value in the viable cells. The quenching dye used in this step, (a) is permeable through a membrane of a viable cell, (b) hardly absorbs fluorescence of the fluorescent dye under a condition of the pH value in the viable cells, but (c) absorbs the fluorescence of the fluorescent dye under a condition different from the pH value of the fluorescent dye. In the step (3), the sample stained with the fluorescent dye and the quenching dye is illuminated by an excitation light for the fluorescent dye under a condition of a pH value different from the pH value in the viable cells and the fluorescence emitted from the sample is collected and detected.

  本发明的目的是提供一种检测有活力细胞的方法，它能快速、方便、准确地检测和定量样品中的有活力细胞。该方法中使用的试剂安全、储存稳定、价格低廉。 该方法包括步骤(1)、(2)和(3)。 在步骤(1)中，通过在样品中加入荧光染料或使样品与荧光染料接触，对细胞进行荧光染色。 在步骤(2)中，向被荧光染料染色的样品中加入淬灭染料，或使样品与淬灭染料接触，条件是 pH 值不同于存活细胞中的 pH 值。该步骤中使用的淬灭染料(a)可透过有活力细胞的膜，(b)在有活力细胞中的 pH 值条件下几乎不吸收荧光染料的荧光，但(c)在不同于荧光染料 pH 值的条件下吸收荧光染料的荧光。 在步骤(3)中，用荧光染料和淬灭染料染色的样品在与存活细胞中的 pH 值不同的条件下被荧光染料的激发光照射，收集并检测样品发出的荧光。
• Modular targeted therapeutic agents and methods of making same
  申请人：Proteonova, Inc.

  公开号：US10206998B2

  公开（公告）日：2019-02-19

  Provided herein are methods for making targeted therapeutics. In several embodiments, the therapeutics are directed against soluble agents such as toxins, venoms, and/or other factors that alter physiological biopathways as well as methods of using such therapeutics to treat patients or patient populations to reduce, eliminate, or inactivate, detrimental soluble agents that such patients or patient populations have been exposed to. In several embodiments, the therapeutics are directed to patient-specific disease markers. In several embodiments, the methods comprise screening a library comprising proteins linked to their cognate mRNAs to identify mRNA-protein pairs that bind to the diseased cells, isolating one or more proteins from the identified mRNA-protein pairs, and conjugating the isolated protein(s) to a therapeutic agent.

  本文提供了制造靶向治疗药物的方法。在几个实施方案中，这些疗法针对可溶性物质，如毒素、毒液和/或其他改变生理生物通路的因素，以及使用这些疗法治疗患者或患者群体的方法，以减少、消除或灭活该患者或患者群体接触过的有害可溶性物质。在几个实施方案中，治疗剂针对患者特异性疾病标志物。在几个实施方案中，这些方法包括筛选包含与其同源mRNA相连的蛋白质的文库，以鉴定与患病细胞结合的mRNA-蛋白质对，从鉴定的mRNA-蛋白质对中分离出一种或多种蛋白质，并将分离出的蛋白质与治疗剂共轭。
• Methods of treating brain edema
  申请人：Snutch Terrance P.

  公开号：US10472635B2

  公开（公告）日：2019-11-12

  Provided are methods for treating or preventing brain edema in a subject by administering an inhibitor of SLC26A11 to the subject. Also included are methods for preventing cell death, cell swelling, or elevated internal concentration of chloride ions in a cell by contacting the cell with an inhibitor of SLC26A11.

  本发明提供了通过向受试者施用 SLC26A11 抑制剂来治疗或预防受试者脑水肿的方法。还包括通过使细胞与 SLC26A11 抑制剂接触来防止细胞死亡、细胞肿胀或细胞内氯离子浓度升高的方法。
• Zeolite molecular sieves for the removal of toxins
  申请人：FRAMEWORKS THERAPEUTICS, LLC

  公开号：US10555969B2

  公开（公告）日：2020-02-11

  Medical use of natural and synthetic zeolites for treatment, prevention, and palliation in humans or animals of deleterious concentrations of ammonia, mercaptans, heavy metals and other toxins by oral administration.

  天然和合成沸石的医疗用途，通过口服给药，治疗、预防和缓解人类或动物体内氨、硫醇、重金属和其他毒素的有害浓度。