吖啶-3,9-二胺 | 951-80-4

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 吖啶-3,9-二胺
• 英文名称: 3,9-diamino-acridine
• 英文别名: 3,9-diaminoacridine；3,9-Diaminoacridin；acridine-3,9-diamine；acridine-3,9-diyldiamine；Acridin-3,9-diyldiamin；2,5-Diaminoacridin
• CAS: 951-80-4
• 化学式: C₁₃H₁₁N₃
• 分子量: 209.25
• InChiKey: AMOPBNMABDFREG-UHFFFAOYSA-N

物化性质

• 熔点：
  146°C
• 沸点：
  338.61°C (rough estimate)
• 密度：
  1.1847 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.9
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

制备方法与用途

类别：有毒物品

毒性分级：中毒

急性毒性：

• 皮下-小鼠LD50: 140 毫克/公斤

可燃性危险特性：可燃；加热分解时释放有毒氮氧化物烟雾

储运特性：库房通风、低温干燥

灭火剂：干粉、泡沫、砂土、二氧化碳，雾状水

反应信息

• 作为反应物：
  描述：

  吖啶-3,9-二胺 在 sodium azide 、 sodium nitrite 作用下， 生成 9-amino-3-azidoacridine
  参考文献：
  名称：

  Identification of an acridine photoaffinity probe for trypanocidal action

  摘要：

  Twenty-four acridine derivatives were screened for trypanocidal activity in Trypanosoma brucei in order to determine which structural features of the acridine molecule confer maximal antiparasitic activity. The synthesis of several new azidoacridine derivatives are also reported as well as an assessment of their value as possible photoaffinity probes for the study of acridine trypanocidal action. The most effective and selective acridine trypanocides, with and without irradiation, were the 3-amino-10-methylacridinium salt derivatives. With brief irradiation, one azidoacridine, 3-amino-6-azido-10-methylacridinium chloride, showed considerable trypanocidal activity at very limiting drug concentrations (10(-7)M) and warrants consideration as a possible photoaffinity probe.

  DOI：

  10.1021/jm00373a010
• 作为产物：
  描述：

  2-anilino-4-nitrobenzoic acid 在 水 、 iron(II) sulfate 、 calcium carbonate 、 三氯氧磷 作用下， 生成 吖啶-3,9-二胺
  参考文献：
  名称：

  Albert; Gledhill, Journal of the Society of Chemical Industry, 1942, vol. 61, p. 159

  摘要：

  DOI：

文献信息

• MATRIX FOR MALDI MASS SPECTROMETRY AND MALDIMASS SPECTROMETRY METHOD
  申请人：Shindo Mitsuru

  公开号：US20140151548A1

  公开（公告）日：2014-06-05

  Provided is a matrix for MALDI mass spectrometry that has a high ability of ionizing low-molecular-weight compounds, and makes it possible to make measurement in a negative ion mode. The matrix is a matrix for mass spectrometry that contains one or more compounds selected from the group consisting of compounds each represented by the following general formula (I), (II) or (III), and their salts thereof. In the formulae (I), (II) and (III), X and Z are each C or N; R 1 and R 5 are each selected from the group consisting of H, an alkyl group, a (substituted) aryl group, a (substituted) arylalkyl group, and a (substituted) heteroaryl group; R 2 and R 6 are each selected from the group consisting of H, an alkyl group, an alkoxyl group, an amino group, a halogen atom, a nitro group, an allyl group, a (substituted) aryl group, and a (substituted) heteroaryl group; and R 7 and R 8 are each selected from the group consisting of H and an amino group provided that a case where R 1 =R 2 =H, and a case where R 7 =R 8 =an amino group are excluded.

  提供的是一种用于MALDI质谱的矩阵，具有高能力电离低分子量化合物的能力，并使得在负离子模式下进行测量成为可能。该矩阵是一种质谱矩阵，包含从由以下通式（I）、（II）或（III）表示的化合物组成的化合物中选择的一个或多个化合物及其盐。在式（I）、（II）和（III）中，X和Z分别为C或N；R1和R5分别选择自H、烷基、（取代）芳基、（取代）芳基烷基和（取代）杂芳基组成的群；R2和R6分别选择自H、烷基、烷氧基、氨基、卤素原子、硝基、烯丙基、（取代）芳基和（取代）杂芳基组成的群；R7和R8分别选择自H和氨基，但排除R1=R2=H和R7=R8=氨基的情况。
• Fluorescent dyes and uses thereof
  申请人：Ramage Robert

  公开号：US09127164B2

  公开（公告）日：2015-09-08

  The present invention relates to fluorescent dyes based on acridine derivatives and use of such dyes, for example, in biochemical and/or cell based assays. A preferred feature of some of the dyes described is their long fluorescence lifetimes and their use to label biological molecules.

  本发明涉及基于吖啶衍生物的荧光染料以及这些染料的应用，例如在生物化学和/或基于细胞的测定中。一些所描述的染料的首选特征是它们的长荧光寿命以及它们用于标记生物分子的应用。
• Cyclic anhydride derivatives of chromophors
  申请人：Theodoropulos, Spyros

  公开号：EP0297763A2

  公开（公告）日：1989-01-04

  Novel chromophor derivatives of cyclic anhydrides are provided which have the ability to react with a variety of organic substrates forming adducts which are useful in analytical techniques for the detection and measurement of biological compounds.

  本研究提供了新型环酐发色团衍生物，它们能够与多种有机基质发生反应，形成加合物，可用于生物化合物的检测和测量分析技术。
• DE393411
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• DE364033
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