烯丙基甲基醚 | 627-40-7

• 物质功能分类: 有机原料 - 醚类化合物及其衍生物 - 醚、醚醇
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 烯丙基甲基醚
• 中文别名: 烯丙基甲醚；3-甲氧丙烯；甲基烯丙基醚；3-甲氧基-1-丙烯；烯丙基甲基乙酯；丙烯基甲醚
• 英文名称: methylallylether
• 英文别名: allyl methyl ether；methallyl alcohol；3-methoxyprop-1-ene
• CAS: 627-40-7
• 化学式: C₄H₈O
• 分子量: 72.1069
• InChiKey: FASUFOTUSHAIHG-UHFFFAOYSA-N

物化性质

• 熔点：
  -115.8°C (estimate)
• 沸点：
  42-43 °C/760 mmHg
• 密度：
  0.768 g/mL at 25 °C
• 闪点：
  -23°C
• 保留指数：
  529
• 稳定性/保质期：
  远离氧化物和氧。

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  5
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• TSCA：
  Yes
• 危险等级：
  3
• 危险品标志：
  Xn,F
• 安全说明：
  S16,S26,S3/7,S36/37/39,S9
• 危险类别码：
  R22,R36,R11
• WGK Germany：
  3
• 海关编码：
  2909199090
• 危险品运输编号：
  3271
• 包装等级：
  II
• 危险类别：
  3
• 储存条件：
  请将存放在密封容器内，并置于阴凉、干燥处。存储地点须远离氧化剂。

SDS

Allyl Methyl Ether Revision number: 1
SAFETY DATA SHEET

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Section 1. BASE INFORMATION
Product name: Allyl Methyl Ether

Revision number: 1

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Section 2. HAZARDS IDENTIFICATION
Classification of the GHS
PHYSICAL HAZARDS
Flammable liquids Category 2
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
ENVIRONMENTAL HAZARDS Not classified
GHS label elements
Pictograms or hazard symbols
Signal word Danger
Hazard statement Highly flammable liquid and vapour
Causes skin irritation
Causes serious eye irritation
Precautionary statements
[Prevention] Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Keep container tightly closed.
Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary
measures against ignition by the static discharge and the spark.
Wash hands thoroughly after handling.
Wear protective gloves/eye protection/face protection.
[Response] IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse
skin with water/shower.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.
[Storage] Store in a well-ventilated place. Keep cool.
[Disposal] Dispose of contents/container through a waste management company authorized by
the local government
Other hazards which do not May form explosive peroxides.
result in classification
Allyl Methyl Ether

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Component(s): Allyl Methyl Ether
Percent: >97.0%(GC)
CAS Number: 627-40-7
Synonyms: 3-Methoxy-1-propene
Chemical Formula: C4H8O

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Section 4. FIRST AID MEASURES
Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Inhalation:
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, carbon dioxide.
media:
Extinguishing media not to Water (It may scatter and spread fire.)
be used:
Specific methods: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
spraying with water. Eliminate all ignition sources if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an
containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding.
up: Adhered or collected material should be promptly disposed of, in accordance with
appropriate laws and regulations.
Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
hazards: case of a fire. Use spark-proof tools and explosion-proof equipment.

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Section 7. HANDLING AND STORAGE
Handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapor or mist. Keep away from heat/sparks/open flame/hot
surfaces. -No smoking. Take measures to prevent the build up of electrostatic
charge. Use explosion-proof equipment. Wash hands and face thoroughly after
handling.
Use a closed system if possible. Use a ventilation, local exhaust if vapor or aerosol
will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Confirm in advance if peroxides exist when operations involving heating such as
distillation are carried out.
Storage
Allyl Methyl Ether

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Section 7. HANDLING AND STORAGE
Storage conditions: Keep container tightly closed. Store in an explosion-poof refregerator.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Law is followed.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: clear
Color: Colorless - Slightly pale yellow
Odor: No data available
pH: No data available
Melting point/freezing point:No data available
Boiling Point/Range: 43 °C
Flash Point: -23°C
Explosive limits
Lower: No data available
Upper: No data available
Density: 0.77
Solubility: Miscible with : Ethanol Ether
Soluble in : Acetone
Insoluble in: Water

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Section 10. STABILITY AND REACTIVITY
Stability: May form explosive peroxides.
No special reactivity has been reported.
Reactivity:
Conditions to avoid: Heat-sensitive
Incompartible materials: oxidizing agents
Hazardous Decomposition Carbon monoxide, Carbon dioxide
Products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Allyl Methyl Ether

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Section 12. ECOLOGICAL INFORMATION
Mobillity in soil
No data available
log Pow:
Soil adsorption (Koc): No data available
No data available
Henry's Law
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system but exert extra care in igniting as this material is
highly flammable. Observe all federal, state and local regulations when disposing of the substance

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Section 14. TRANSPORT INFORMATION
3: Flammable liquid.
Hazards Class:
UN-No: 3271
Ethers, n.o.s.
Proper shipping name:
Packing group: II

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26,
2002): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were
prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  烯丙基甲基醚 在 过氧乙酸 作用下， 生成 (甲氧基甲基)环氧乙烷
  参考文献：
  名称：

  使用空间效应和电子效应的比较来推断涉及三元环状中间体的逐步亲电加成反应中的机理信息

  摘要：

  IP与烯烃与ArSCl，MeCO 3 H，Ag +或HgCl 2的反应的相对反应性或形成常数的相关性表明，络合反应显示出空间依赖性，第一步确定反应速率的加成反应是空间独立的，并且第二步的速率确定在空间上是依赖的。

  DOI：

  10.1016/s0040-4039(00)82306-0
• 作为产物：
  描述：

  (甲氧基甲基)环氧乙烷 在 一氧化碳 、 C₂₉H₃₂IrN₅O 、 bis(trifluoromethane)sulfonimide lithium 作用下， 以 氘代苯 为溶剂， 80.0 ℃ 、1.0 MPa 条件下， 反应 24.0h， 以52%的产率得到烯丙基甲基醚
  参考文献：
  名称：

  用一氧化碳对环氧化物进行脱氧。

  摘要：

  提出了使用一氧化碳作为直接还原剂将末端环氧化物和内部环氧化物脱氧成相应的烯烃。该反应由羰基钳-铱(I)络合物与路易斯酸助催化剂结合均匀催化，实现环氧化物底物的预活化，以及从γ-2-铱丁内酯中消除CO 2中间的。特别是末端烷基环氧化物在CO气氛下、苯或甲苯中、80-120℃下反应顺利，并且不会明显异构化为内烯烃。详细的研究揭示了环氧化物C−O键活化机制中底物依赖性变化，该变化发生在保留构型的氧化加成和导致构型反转的S N 2 反应之间。

  DOI：

  10.1002/chem.202002651
• 作为试剂：
  描述：

  diazoethane 在 rhodium(II) acetate dimer 烯丙基甲基醚 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 以75%的产率得到3-(<<-1-Methyl-2-oxo-2-(2-(phenylethynyl)phenyl)ethylidene>hydrazono>phenylmethyl)inden-1-one
  参考文献：
  名称：

  A Tandem Cyclization-Onium Ylide Rearrangement-Cycloaddition Sequence for the Synthesis of Benzo-Substituted Cyclopentenones

  摘要：

  A new annulation sequence leading to benzo-substituted cyclopentenones is effected by treating o-alkynyl-substituted alpha-diazoacetophenones containing tethered heteroatoms with Rh(II) carboxylates. The reaction involves addition of the initially formed keto carbenoid onto the acetylenic pi-bond to give a rearranged vinyl carbenoid. Sulfonium ylide formation occurred both intra- and intermolecularly when the reaction was carried out in the presence of a sulfide. In the case where an ether oxygen was present on the backbone of the vinyl carbenoid, the resulting oxonium ylide underwent a [1,2]- or [2,3]-shift to give the rearranged product. These cyclic metallocarbenoids were also found to interact with a neighboring carbonyl or oximino pi-bond to produce carbonyl or azomethine ylides. The 1,3-dipoles generated in this manner were trapped with dimethyl acetylenedicarboxylate. The domino transformation was also performed intramolecularly by attaching a trapping agent directly to the carbonyl group. Incorporation of an amido carbonyl on the alkyne side chain was found to dramatically alter the course of the tandem annulation reaction. A novel rearranged cycloadduct was formed in high yield whose structure was elucidated by X-ray crystallography. The mechanism for its formation involves the opening of a transient intermediate oxabicyclo[2.2.1]heptane followed by a Wagner-Meerwein rearrangement.

  DOI：

  10.1021/jo00106a014

文献信息

• Convenient Methods for the Synthesis of a Library of Hemilabile Phosphines
  作者：M. Jiménez、Jesús Pérez-Torrente、M. Bartolomé、Luis Oro

  DOI：10.1055/s-0028-1088060

  日期：2009.6

  A series of novel functionalized phosphines of hemi­labile character, R2P(CH2)nZ, have been prepared from diaryl­phosphines using several synthetic methodologies. The synthetic methods include the alkylation of lithium diarylphosphide or (di­arylphosphino)borane adducts with functionalized halogenoalkanes, X(CH2)nZ, and the photochemical hydrophosphination of suitable functionalized allyl or vinyl

  一系列hemilabile字符的新的官能化的膦的，R 2 P（CH 2）Ñ Z，已经从使用几种合成方法二芳基膦制备。合成方法包括用官能化的卤代烷烃X（CH 2）n Z对二芳基磷酸锂或（二芳基膦基）硼烷加合物进行烷基化，以及合适的官能化烯丙基或乙烯基衍生物的光化学加氢磷酸化，H 2 C = CHZ或H 2 C = CHCH 2 Z，使用白光。甲范围R 2 PH（R = BN，4-MeOC 6 H ^ 4，4-MEC 6 ħ 4，2-MEC为了调节磷供体原子上的电子密度，已经使用了6 H 4，Ph，4-F 3 CC 6 H 4）。通过选择供体基团（Z = OMe，OEt，OBu，NMe 2）或柔性碳链的长度（n = 2、3），可以改变半不稳定片段的配位能力。由二芳基氯膦和烯丙基溴化镁制备了半不稳定的氟化烯丙基膦，R 2 PCH 2 CH ＝ CH 2（R ＝ 4-FC 6 H 4，C 6 F 5）。
• [EN] 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS<br/>[FR] DÉRIVÉS DE PIPÉRIDINE 3,4-SUBSTITUÉE CONVENANT COMME INHIBITEURS DE LA RÉNINE
  申请人：MERCK FROSST CANADA LTD

  公开号：WO2009140769A1

  公开（公告）日：2009-11-26

  The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position lsoqumolone and having the Formula (I) : The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

  本发明涉及具有4-位lsoqumolone的3,4-取代哌啶基肾素抑制剂化合物，其化学式为（I）：该发明还涉及含有上述化合物的药物组合物，以及它们在治疗心血管事件和肾功能不全中的用途。
• Photochemical polar addition of trialkylboranes
  作者：N. Miyamoto、S. Isiyama、K. Utimoto、H. Nozaki

  DOI：10.1016/s0040-4020(01)93364-2

  日期：1973.1

  cis-2-Alkylcyclohexanols are obtained stereoselectively upon irradiation of a mixture of cyclohexene and the corresponding trialkylborane in the presence of p-xylene as a sensitizer and upon the successive oxidation of the photolysate with alkaline H2O2. The similar reaction of 1-ethylcyclohexene yields 2,2-dialkylcyclohexanols. Cycloheptene also reacts with the boranes to afford cis-2-alkylcycloheptanols

  在对二甲苯作为敏化剂的存在下，对环己烯和相应的三烷基硼烷的混合物进行辐照，然后用碱性H 2 O 2连续氧化光解产物，可通过立体选择获得顺式-2-烷基环己醇。1-乙基环己烯的类似反应产生2，2-二烷基环己醇。环庚烯还与硼烷反应以提供顺式-2-烷基环庚醇。通过假定高度应变的反式-环己烯或-庚烯为反应性物质来解释这些反应。光化学产生的反式-环-辛-2-烯酮和顺式，反式-环-辛基-2,7-二烯酮与硼热反应，分别得到3-烷基环辛酮和顺式-7-烷基环辛-2-烯酮。cr啶与硼烷的光反应导致还原性烷基化，以相当好的收率得到9-烷基ac啶。
• Alkylation and acylation of phenylthio 2,3-dideoxyhex-2-enopyranosides at the anomeric centre by polarity inversion
  作者：Serafín Valverde、Silvestre García-Ochoa、Manuel Martín-Lomas

  DOI：10.1039/c39870000383

  日期：——

  Alkylation and acylation of phenylthio 2,3-dideoxy-α-D-erythro-hex-2-enopyranoside derivatives at the anomeric centre by polarity inversion give C-1 alkylated or acylated phenylthio 2,3-dideoxy-α-D-erythro-hex-2-enopyranosides.

  烷基化和苯硫基-2,3-二脱氧α-酰化d -赤由极性反转给予C-1烷基化或酰化的苯硫基-2,3-二脱氧α-在异头中心-己-2-烯吡喃糖苷衍生物d -赤-己-2-烯吡喃糖苷。
• Glucocorticoid receptor antagonists for treatment of diabetes
  申请人：Abbott Laboratories

  公开号：US06593480B2

  公开（公告）日：2003-07-15

  Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  公式I的化合物对治疗II型糖尿病、肥胖、高血糖、葡萄糖清除不足、高胰岛素血症、高三酸甘油脂血症和高循环糖皮质激素水平有用，包括该化合物的制剂、含有该化合物的组合物以及使用该化合物进行治疗的方法。

表征谱图