(甲氧基甲基)环氧乙烷 | 930-37-0

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 环烃
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 中文名称: (甲氧基甲基)环氧乙烷
• 中文别名: 环氧丙基甲基醚；2,3-环氧丙烷甲基醚；1,2-环氧-3-甲氧基丙烷；甲基缩水甘油醚
• 英文名称: glycidyl methyl ether
• 英文别名: (rac) glycidyl methyl ether；2-(methoxymethyl)oxirane
• CAS: 930-37-0
• 化学式: C₄H₈O₂
• mdl: MFCD00005140
• 分子量: 88.1063
• InChiKey: LKMJVFRMDSNFRT-UHFFFAOYSA-N

物化性质

• 沸点：
  110°C
• 密度：
  0,98 g/cm3
• 闪点：
  24°C
• 溶解度：
  可溶于氯仿（少许）、甲苯（少许）
• 物理描述：
  Methyl glycidyl ether is a clear colorless liquid. (NTP, 1992)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

毒理性

• 非人类毒性摘录

它们对眼睛、皮肤和呼吸道非常刺激。/缩水甘油醚/

...THEY ARE VERY IRRITATING TO EYES, SKIN, & RESPIRATORY TRACT. /GLYCIDYL ETHERS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

1,2-环氧-3-甲氧基丙烷对肺炎克雷伯菌具有致突变性。

1,2-EPOXY-3-METHOXYPROPANE WAS MUTAGENIC IN KLEBSIELLA PNEUMONIAE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

将0.1毫升的1,2-环氧-3-甲氧基丙烷涂在剃毛的豚鼠背部，每10天涂4次。在2周的休息期后，豚鼠在剃光的腹部进行挑战。在测试的49只豚鼠中，有两只变得敏感。

TOPICAL APPLICATION OF 0.1 ML ALIQUOT OF 1,2-EPOXY-3-METHOXYPROPANE TO CLIPPED & DEPILATED BACKS OF GUINEA PIGS 4 TIMES IN 10 DAYS. AFTER 2 WK REST PERIOD, GUINEA PIGS WERE CHALLENGED ON THE CLIPPED FLANKS. TWO OF THE 49 GUINEA PIGS TESTED BECAME SENSITIZED.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  3.1
• 安全说明：
  S16
• 危险类别码：
  R10
• 危险品运输编号：
  UN 3271
• 海关编码：
  2910900090
• 危险类别：
  3.1
• 包装等级：
  II
• 储存条件：
  室温且干燥环境中保存。

SDS

Glycidyl Methyl Ether
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: Glycidyl Methyl Ether

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS
Category 3
Flammable liquids
HEALTH HAZARDS
Category 4
Acute toxicity (Oral)
Acute toxicity (Dermal) Category 3
Category 2
Skin corrosion/irritation
Serious eye damage/eye irritation Category 2A
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Danger
Flammable liquid and vapour
Hazard statements
Harmful if swallowed
Toxic in contact with skin
Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
[Prevention]
Keep container tightly closed.
Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary
measures against ignition by the static discharge and the spark.
Do not eat, drink or smoke when using this product.
Wash hands thoroughly after handling.
Wear protective gloves and eye/face protection.
Glycidyl Methyl Ether

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Section 2. HAZARDS IDENTIFICATION
[Response] IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
Rinse mouth.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse
skin with water/shower.
If skin irritation occurs: Get medical advice/attention.
Remove/Take off immediately all contaminated clothing.
Wash contaminated clothing before reuse.
Call a POISON CENTER or doctor/physician if you feel unwell.
[Storage] Store in a well-ventilated place. Keep cool.
Store locked up.
[Disposal] Dispose of contents/container through a waste management company authorized by
the local government.

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Glycidyl Methyl Ether
Components:
Percent: >85.0%(GC)
CAS Number: 930-37-0
Synonyms: 1,2-Epoxy-3-methoxypropane
Chemical Formula: C4H8O2

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Section 4. FIRST AID MEASURES
Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Inhalation:
Call a POISON CENTER or doctor/physician if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. Call a POISON CENTER or doctor/physician.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water in large amounts, carbon dioxide.
media:
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
spraying with water. Eliminate all ignition sources if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Use extra personal protective equipment (self-contained breathing apparatus). Keep
Personal precautions,
protective equipment and people away from and upwind of spill/leak. Ensure adequate ventilation. Entry to non-
emergency procedures: involved personnel should be controlled around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an
containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding.
up: Adhered or collected material should be promptly disposed of, in accordance with
appropriate laws and regulations.
Glycidyl Methyl Ether

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Section 6. ACCIDENTAL RELEASE MEASURES
Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
hazards: case of a fire. Use spark-proof tools and explosion-proof equipment.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Keep away from heat/sparks/open flame/hot
surfaces. -No smoking. Take measures to prevent the build up of electrostatic
charge. Use explosion-proof equipment. Wash hands and face thoroughly after
handling.
Use a closed system if possible. Use a ventilation, local exhaust if vapour or aerosol
will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool, dark and well-ventilated place.
Store locked up.
Store away from incompatible materials such as oxidizing agents.
Comply with laws.
Packaging material:

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Half or full facepiece respirator, self-contained breathing apparatus(SCBA), supplied
air respirator, etc. Use respirators approved under appropriate government standards
and follow local and national regulations.
Impervious gloves.
Hand protection:
Eye protection: Safety goggles. A face-shield, if the situation requires.
Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: Clear
Colorless - Very pale yellow
Colour:
Odour: Pungent
pH: No data available
Melting point/freezing point:No data available
Boiling point/range: 110°C
Flash point: 25°C
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: 0.99
Solubility(ies):
[Water] Miscible
[Other solvents]
Soluble: Methanol, Ethanol
Log Pow: -0.17

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Spark, Open flame, Static discharge
Conditions to avoid:
Incompatible materials: Oxidizing agents, Acids, Bases
Glycidyl Methyl Ether

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Section 10. STABILITY AND REACTIVITY
Hazardous decomposition Carbon monoxide, Carbon dioxide
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: orl-rat LD50:467 uL/kg
skn-rbt LD50:707 uL/kg
Skin corrosion/irritation: skn-rbt 500 uL/24H SEV
Serious eye eye-rbt 10 uL MOD
damage/irritation:
Germ cell mutagenicity: mmo-klp 200 umol/L (-S9)
mmo-sat 100 ug/plate (+S9)
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available
RTECS Number: TZ3530000

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
No data available
Crustacea:
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative 1.0
potential(BCF):
Mobility in soil
-0.17
Log Pow:
Soil adsorption (Koc): 19.3
No data available
Henry's Law
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

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Section 14. TRANSPORT INFORMATION
3: Flammable liquid.
Hazards Class:
Subsidiary risk: 6.1: Toxic substance.
1992
UN-No:
Proper shipping name: Flammable liquid, toxic, n.o.s.
Packing group: III

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
Glycidyl Methyl Ether

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (甲氧基甲基)环氧乙烷 在 高氯酸 、 水 作用下， 以83%的产率得到3-甲氧基-1,2-丙二醇
  参考文献：
  名称：

  Crown cation complex effects. 22. Enhancement of cation binding in lariat ethers bearing a methyl group at the quaternary, pivot carbon atom

  摘要：

  DOI：

  10.1021/jo00156a018
• 作为产物：
  描述：

  1-氯-3-甲氧基-2-丙醇 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 8.0h， 以88%的产率得到(甲氧基甲基)环氧乙烷
  参考文献：
  名称：

  合理设计 2-羟丙基鏻盐作为癌细胞线粒体靶向载体：合成、结构和生物学特性

  摘要：

  已证明，对于多种环氧化合物，它们与三氟甲磺酸三苯基鏻的相互作用具有高化学选择性，并导致形成 3-位被烷氧基、烷基羧基取代的 (2-羟丙基)三苯基鏻三氟甲磺酸盐3卤素，以高产率分离。采用在三氟化硼乙醚合物存在下环氧氯丙烷与醇反应的方法，然后用碘取代氯并用三苯基膦处理，也得到2-羟丙基三苯基碘化鏻4 。建立了所获得的鏻盐的分子和超分子结构，并揭示了它们与十二指肠腺癌相关的高抗肿瘤活性。基于鏻盐3和L -α-磷脂酰胆碱(PC)的脂质体系统的形成用于提高生物利用度并降低毒性。它们是通过薄膜再水化方法生产的，并表现出细胞毒性特性。鏻盐3和4的合理设计具有作为靶向递送至肿瘤细胞线粒体的新载体的巨大潜力。

  DOI：

  10.3390/molecules26216350
• 作为试剂：
  描述：

  乙醇 、 2'-nitro-3-phenylpropananilide 在 (甲氧基甲基)环氧乙烷 、 potassium acetate 作用下， 反应 35.0h， 以97%的产率得到3-苯丙酸乙酯
  参考文献：
  名称：

  酸性酰胺助剂的环氧化物介导脱保护方法

  摘要：

  已经开发了一种去除通用酸性酰胺助剂的实用方法。在KOAc存在下，酰胺的轻松醇解是通过环氧化物实现的，该环氧化物的机理类似于Myers助剂的去除。该方案已应用于高效，低成本去除各种酰胺底物及其C–H功能化产品，代表着朝着开发C–H活化多功能导向基团迈出的一步。

  DOI：

  10.1021/acs.orglett.7b02841

文献信息

• [EN] COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS<br/>[FR] COMPOSÉS POUR INHIBER LA PROLIFÉRATION CELLULAIRE DANS LES CANCERS INDUITS PAR L'EGFR
  申请人：ARIAD PHARMA INC

  公开号：WO2013169401A1

  公开（公告）日：2013-11-14

  The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of Formula (I), wherein the variables are as defined herein.

  这项发明涉及化合物、药物组合物和治疗EGFR驱动的Formula (I)癌症患者的方法，其中变量如本文所定义。
• [EN] ANTICANCER BENZOPYRAZINES VIA THE INHIBITION OF FGFR KINASES<br/>[FR] BENZOPYRAZINES ANTICANCÉREUSES PAR LE BIAIS DE L'INHIBITION DE FGFR KINASES
  申请人：ASTEX THERAPEUTICS LTD

  公开号：WO2013061081A1

  公开（公告）日：2013-05-02

  The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

  这项发明涉及新的喹啉衍生物化合物，包括含有该化合物的药物组合物，用于制备该化合物的方法以及该化合物在治疗疾病（例如癌症）中的用途。
• [EN] METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION<br/>[FR] MÉTHODES ET COMPOSÉS POUR LA RESTAURATION DE LA FONCTION DU P53 MUTANT
  申请人：PMV PHARMACEUTICALS INC

  公开号：WO2021061643A1

  公开（公告）日：2021-04-01

  Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

  癌基因和肿瘤抑制基因的突变促成了癌症的发展和进展。本公开披露描述了一种恢复p53突变体野生型功能的化合物和方法。本发明的化合物可以结合突变型p53，并恢复p53突变体结合DNA并激活参与肿瘤抑制的下游效应子的能力。所披露的化合物可用于减少含有p53突变的癌症的进展。
• Prodrugs of compounds that inhibit TRPV1 receptor
  申请人：Gomtsyan R. Arthur

  公开号：US20070099954A1

  公开（公告）日：2007-05-03

  Compounds of formula (I) wherein A, R 1 , R 2 , and R 3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.

  式（I）的化合物 其中A，R1，R2和R3在规范中定义，并且这些化合物可用作治疗化合物，特别用于治疗与炎症、疼痛、膀胱过度活动、尿失禁以及由TRPV1引起或加重的其他疾病或症状相关的紊乱。
• [EN] NOVEL IMIDAZOLE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'IMIDAZOLE
  申请人：TAISHO PHARMA CO LTD

  公开号：WO2018216822A1

  公开（公告）日：2018-11-29

  Provided are novel compounds represented by the following general formula [1] or pharmaceutically acceptable salts thereof, that inhibit LpxC, as well as pharmaceutical drugs comprising those compounds or pharmaceutically acceptable salts thereof, that exhibit antimicrobial activity against gram-negative bacteria including multi-drug resistant strains and that are useful in the treatment of bacterial infections.

  提供了由以下一般式[1]表示的新化合物或其药用盐，其抑制LpxC，以及包含这些化合物或其药用盐的药物，对革兰氏阴性细菌包括多药耐药菌株表现出抗微生物活性，并且在治疗细菌感染中有用。

表征谱图