(Z)-2,3,4,5-tetraglyceryl-20,21-dihydroxy-henicos-9-enoic acid glyceryl ester | 9007-48-1

• 物质功能分类: 食品添加剂 - 乳化剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-2,3,4,5-tetraglyceryl-20,21-dihydroxy-henicos-9-enoic acid glyceryl ester
• 英文别名: 2,3-dihydroxypropyl (Z)-2,3,4,5-tetrakis(2,3-dihydroxypropyl)-20,21-dihydroxyhenicos-9-enoate
• CAS: 9007-48-1
• 化学式: C₃₆H₇₀O₁₄
• 分子量: 726.9
• InChiKey: RAIRMBHOCCUQAG-ALCCZGGFSA-N

物化性质

• 熔点：
  <0 °C
• LogP：
  -4.147 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  50
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  269
• 氢给体数：
  12
• 氢受体数：
  14

安全信息

• 海关编码：
  3907200000
• WGK Germany：
  1

制备方法与用途

化学性质
这是一种浅黄色的黏稠液体，无特殊气味，味道微甜。它可溶于苯、甘油、丙二醇、热乙醇和冷的乙酸乙酯，但不溶于冷水；在热水中搅拌后可以分散成乳浊液。其HLB值为8～14.5（四聚至十聚物）。实验结果显示，大白鼠的LD₅₀为20g/kg，根据FAO/WHO（1994）的规定，ADI值为0～25mg/kg。

用途
它是一种良好的W/O型食品乳化剂，具备优良的分散和乳化作用。我国规定其可用于乳酸菌饮料、植物蛋白饮料、雪糕、冰棍和冰淇淋中，最大使用量为10.0g/kg。

生产方法
有关聚甘油单硬脂酸酯的生产方法，请参见相关资料。

文献信息

• Cosmetic composition for treating dry skin
  申请人：UNILEVER PLC

  公开号：EP0556957A1

  公开（公告）日：1993-08-25

  A cosmetic composition effective in the reduction of water loss through the stratum corneum comprising three components A, B and C, wherein A is a molecule having at least two hydrocarbon chains and a polar head group for which:Vaolc > 0.5 ≦ 1.0; Component B is a molecule having one long hydrocarbon chain and a polar head group; and component C is capable of stabilising any lipid bilayers assisting the formulation of lipid bilayers and formed in the composition; providing that the molar ratio of A:B:C is 1:1.5 to 6.0:1.1 to 8.0.

  一种能有效减少通过角质层流失水分的化妆品组合物，由 A、B 和 C 三种成分组成，其中 A 是一种分子，至少有两条烃链和一个极性头基，其中：Vaolc > 0.5 ≦ 1.0； 成分 B 是具有一条长烃链和一个极性头基的分子；成分 C 能够稳定任何协助脂质双层膜配方并在组合物中形成的脂质双层膜；条件是 A:B:C 的摩尔比为 1:1.5 至 6.0:1.1 至 8.0。
• COSMETIC WATER-IN-OIL MICROEMULSION
  申请人：Ionia Azure AG

  公开号：EP3308766A1

  公开（公告）日：2018-04-18

  A cosmetic water-in-oil microemulsion having advantageous rheological properties comprising: i) 20 - 40% w/w of oil phase ingredients with spreadability value of above 1700 mm2/10 min, ii) 15 - 35% w/w of oil phase ingredients with spreadability value between 1000 and 1700 mm2/10 min, iii) 1 - 15% w/w of oil phase ingredients with spreadability value between 500 and 999 mm2/10 min, iv) 0 - 10 % w/w of oil phase ingredients with spreadability value of below 500 mm2/10 min, v) 5 - 30 % w/w of fatty acid ester(s) of glycerol or fatty acid ester(s) of polyglycerol, vi) 5 - 20% w/w of water, co-surfactant(s) and optionally co-solvent(s), cosmetic active ingredient(s), skin care ingredient(s), water-soluble extract(s) of plant material and cosmetic auxiliary ingredient(s).

  一种具有良好流变特性的油包水化妆品微乳液，包括i) 20 - 40% w/w 油相成分，延展性高于 1700 mm2/10 min； ii) 15 - 35% w/w 油相成分，延展性介于 1000 和 1700 mm2/10 min； iii) 1 - 15% w/w 油相成分，延展性介于 500 和 999 mm2/10 min； iv) 0 - 10 % w/w 油相成分，延展性低于 500 mm2/10 min、v) 5 - 30% w/w 的甘油脂肪酸酯或聚甘油脂肪酸酯， vi) 5 - 20% w/w 的水、助表面活性剂和可选的助溶剂、化妆品活性成分、护肤成分、水溶性 植物提取物和化妆品辅助成分。
• Abuse resistant capsule
  申请人：R.P. Scherer Technologies, LLC

  公开号：US10420729B2

  公开（公告）日：2019-09-24

  The present invention is directed to an immediate release and extended release capsule or capsule fill which mitigates the abuse of abuse-susceptible active pharmaceutical ingredients by direct intravenous injection. The fill comprises a parenteral abuse resistant liquid formulation which when mixed with water and heated, results in a turbid, viscous or bubbling mixture that is not injectable with a standard insulin syringe. The abuse-susceptible active pharmaceutical ingredient is selected from the group consisting of opiates, opioids, tranquilizers, stimulants and narcotics.

  本发明涉及一种速释和缓释胶囊或胶囊填充剂，它可减少通过直接静脉注射滥用易滥用的活性药物成分。填充物包括一种肠外抗滥用液体制剂，当与水混合并加热时，会产生一种浑浊、粘稠或起泡的混合物，不能用标准胰岛素注射器注射。抗滥用活性药物成分选自阿片类、阿片类、镇静剂、兴奋剂和麻醉剂。
• Use of aldehydes formulated with nanoparticles and/or nanoemulsions to enhance disease resistance of plants to liberibacters
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US10772326B2

  公开（公告）日：2020-09-15

  Methods and compositions based upon natural phenolic aromatic aldehydes (ex: cinnamaldehyde, benzaldehyde) are provided, which find use as curing agents for systemic bacterial infections of living plants, in particular against Gram negative bacteria and more particularly species of Liberibacter, including Ca. Liberibacter asiaticus. The curing agent compositions described are used synergistically with other antimicrobial compounds, such as those that plants manufacture or release as a result of biotic or abiotic stresses, including the application of the subject aldehydes, certain proteins, whether produced by recombinant methods or not, nanoparticles, nanoemulsions, or by natural essential oils such as carvacrol or allicin. The aromatic aldehydes have high volatility and exhibit phytotoxicity when applied above certain amounts. Systemic infections and infestations of a variety of plant parts can be treated, including those of leaves and roots. Methods of applying the compositions for agriculture use are disclosed.

  提供了基于天然酚类芳香醛（例如：肉桂醛、苯甲醛）的方法和组合物，可用作活体植物系统性细菌感染的固化剂，特别是针对革兰氏阴性细菌，尤其是自由杆菌的种类，包括Ca.asiaticus）。所述固化剂组合物可与其他抗微生物化合物协同使用，例如植物在生物或非生物胁迫下制造或释放的化合物，包括应用所述醛类、某些蛋白质（无论是否通过重组方法生产）、纳米颗粒、纳米乳液或天然精油（如香芹酚或大蒜素）。芳香醛具有高挥发性，施用超过一定量时会产生植物毒性。可以治疗多种植物部位的系统感染和侵染，包括叶片和根部的感染和侵染。此外，还公开了用于农业用途的组合物的施用方法。
• Cosmetic water-in-oil microemulsion
  申请人：IONIA AZURÉ AG

  公开号：US11020328B2

  公开（公告）日：2021-06-01

  A cosmetic water-in-oil microemulsion having advantageous rheological properties comprising: i) 20-40% w/w of oil phase ingredients with spreadability value of above 1700 mm2/10 min, ii) 15-35% w/w of oil phase ingredients with spreadability value between 1000 and 1700 mm2/10 min, iii) 1-15% w/w of oil phase ingredients with spreadability value between 500 and 999 mm2/10 min, iv) 0-10% w/w of oil phase ingredients with spreadability value of below 500 mm2/10 min, v) 5-30% w/w of fatty acid ester(s) of glycerol or fatty acid ester(s) of polyglycerol, vi) 5-20% w/w of water, co-surfactant(s) and optionally co-solvent(s), cosmetic active ingredient(s), skin care ingredient(s), water-soluble extract(s) of plant material and cosmetic auxiliary ingredient(s).

  一种具有良好流变特性的油包水化妆品微乳液，包括i) 20-40% w/w 油相成分，延展性高于 1700 mm2/10 min； ii) 15-35% w/w 油相成分，延展性介于 1000 和 1700 mm2/10 min； iii) 1-15% w/w 油相成分，延展性介于 500 和 999 mm2/10 min； iv) 0-10% w/w 油相成分，延展性低于 500 mm2/10 min、v) 5-30% w/w 的甘油脂肪酸酯或聚甘油脂肪酸酯， vi) 5-20% w/w 的水、助表面活性剂和可选的助溶剂、化妆品活性成分、护肤成分、水溶性 植物提取物和化妆品辅助成分。