/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aldehydes and Related Compounds/
/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Aggressive airway management may be necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aldehydes and Related Compounds/
/SRP:/ Advanced treatment: Consider Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Intubation should be considered at the first sign of upper airway obstruction caused by edema. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aldehydes and Related Compounds/
/SIGNS AND SYMPTOMS/ Sensitivity to alpha-amylcinnamic aldehyde (alpha-AcAld) is apparently uncommon, but, like allergy to alpha-amylcinnamic alcohol (alpha-AcAlc), it often accompanies allergy to the perfume in Mycolog cream. Although alpha-AcAlc is a known ingredient, alpha-AcAld is not. However, gas-liquid chromatographic analysis shows alpha-AcAld to be present. Of fourteen persons sensitive to either chemical, ten reacted to both. Of these, one man and three women were markedly sensitive, and all three women had chronic recalcitrant vulvar eczema. That condition might have been the cause as well as the result of sensitization, but reexposure to a suspected product reproduced the eruption in both persons tested. Its use with other potent sensitizers, e.g., ethylenediamine, to treat irritations and chronic eczemas in an area of high absorption may partly explain development of allergy to a relatively weak sensitizer.
/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ 15 male and 15 female FDRL rats ... were fed diet containing 2% test substance diluted in cotton-seed oil for 12 weeks. At 90 days, autopsy was performed. Hematological and blood chemical determinations were also made. No treatment related adverse effects were noted in the parameters measured. This study demonstrates a NOAEL in rats ...to be 2% in feed.
通过浸渍法合成了负载在介孔分子筛SiO 2 / Al 2 O 3上的三甲氧基甲硅烷基丙胺[（CH 3 O）3 Si（CH 2）3 NH 2 ]负载的一系列胺催化剂。各种芳香醛和1-庚醛的醛醇缩合用于测试胺官能化SiO 2 / Al 2 O 3的酸碱协同作用。溶剂，反应温度，苯甲醛与1-庚醛摩尔比，不同载体（SiO 2，Al 2 O 3和SiO 2 -Al 2 O 3），催化剂用量和催化剂的可回收性进行了研究。负载了5 mmol胺的样品显示最高的苯甲醛转化率（100％）和对茉莉醛的选择性（97％）。
Colloidal Palladium Nanoparticles with In Situ H<sub>2</sub>: Reducing System for <font>α</font>,<font>β</font>-Unsaturated Carbonyl Compounds
作者：Kathlia A. De Castro、Seungchan Oh、Jongchan Yun、Jin Kyu Lim、Gwangil An、Dong Kook Kim、Hakjune Rhee
DOI：10.1080/00397910902788117
日期：2009.9.8
Abstract A new reducing system comprising Pd(OAc)2 and NaBH4 in methanol to generate palladium nanoparticles has been efficiently utilized to reduce a variety of unsaturated carbonylcompounds. These were reduced to their corresponding saturated alcohols and fully saturated compounds in selected cases. This protocol presents alternative and mild reaction conditions for reduction.
Highly pH-Dependent Chemoselective Transfer Hydrogenation of α,β-Unsaturated Aldehydes in Water
作者：Nianhua Luo、Jianhua Liao、Lu Ouyang、Huiling Wen、Jitian Liu、Weiping Tang、Renshi Luo
DOI：10.1021/acs.organomet.9b00353
日期：2019.8.12
electron-poor substituents on the aryl group of α,β-unsaturated aldehydes can be tolerated, affording the corresponding products in excellent yields with high TOF values. High selectivity and yields were also observed for α,β-unsaturated aldehydes with aliphatic substituents. Our mechanistic investigations indicate that the pH value is critical to the chemoselectivity.
Rhodium-catalyzed synthesis of 1,2-dihydropyridine by a tandem reaction of 4-(1-acetoxyallyl)-1-sulfonyl-1,2,3-triazole
作者：Haican Dai、Sisi Yu、Wanli Cheng、Ze-Feng Xu、Chuan-Ying Li
DOI：10.1039/c7cc02521a
日期：——
A tandem reaction of 4-(1-acetoxyallyl)-1-sulfonyl-1,2,3-triazole including formation of α-imino rhodium carbene, 1,2-migration of an acetoxy group and six electron electrocyclic ring closure was reported. The migration of the OAc group with excellent chemoselectivity was the crucial process, leading to the formation of 1,2-dihydropyridine specifically in up to 90% yield. Several transformations of
Transfer Hydrogenation of Aldehydes and Ketones with Isopropanol under Neutral Conditions Catalyzed by a Metal–Ligand Bifunctional Catalyst [Cp*Ir(2,2′-bpyO)(H<sub>2</sub>O)]
作者：Rongzhou Wang、Yawen Tang、Meng Xu、Chong Meng、Feng Li
DOI：10.1021/acs.joc.7b03174
日期：2018.2.16
A Cp*Ir complex bearing a functional bipyridonate ligand [Cp*Ir(2,2′-bpyO)(H2O)] was found to be a highly efficient and general catalyst for transfer hydrogenation of aldehydes and chemoselective transfer hydrogenation of unsaturated aldehydes with isopropanol under neutral conditions. It was noteworthy that many readily reducible or labile functional groups such as nitro, cyano, ester, and halide
Ambient-pressure highly active hydrogenation of ketones and aldehydes catalyzed by a metal-ligand bifunctional iridium catalyst under base-free conditions in water
high active catalytic system for the hydrogenation of ketones and aldehydes to produce corresponding alcohols under atmospheric-pressure H2 gas and ambient temperature conditions was developed by a water-soluble metal–ligand bifunctional catalyst [Cp*Ir(2,2′-bpyO)(OH)][Na] in water without addition of a base. The catalyst exhibited high activity for the hydrogenation of ketones and aldehydes. Furthermore
