2’,6’-二羟基-4,4’-二甲氧基二氢查耳酮 | 35241-54-4

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 中文名称: 2’,6’-二羟基-4,4’-二甲氧基二氢查耳酮
• 中文别名: 2′,6′-DIHYDROXY-4,4′-DIMETHOXYDIHYDROCHALCONE2',6'-二羟基-4,4'-二甲氧基二氢查耳酮；2',6'-二羟基-4,4'-二甲氧基二氢查耳酮
• 英文名称: 2',6'-dihydroxy-4',4-dimethoxy-dihydrochalcone
• 英文别名: 2',6'-Dihydroxy-4,4'-dimethoxydihydrochalcone；2',6'-dihydroxy-4',4-dimethoxydihydrochalcone；calomelanen；1-(2,6-dihydroxy-4-methoxy-phenyl)-3-(4-methoxy-phenyl)-propan-1-one；1-(2,6-Dihydroxy-4-methoxy-phenyl)-3-(4-methoxy-phenyl)-propan-1-on；2',2'-dihydroxy-4'-methoxy-3-(4-methoxy-phenyl)-propiophenone；1-(2,6-dihydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)propan-1-one
• CAS: 35241-54-4
• 化学式: C₁₇H₁₈O₅
• 分子量: 302.327
• InChiKey: VVDZZNWYISOIDK-UHFFFAOYSA-N

物化性质

• 熔点：
  147°C

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2914509090
• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  2’,6’-二羟基-4,4’-二甲氧基二氢查耳酮 在 palladium on activated charcoal sodium hydroxide 、 氰基磷酸二乙酯 、 氢气 、 potassium carbonate 、 三乙胺 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 80.0h， 生成 homoseryl>glycine
  参考文献：
  名称：

  Kamiya, Shintaro; Esaki, Sachiko; Shiba, Naoko, Agricultural and Biological Chemistry, 1989, vol. 53, # 5, p. 1365 - 1374

  摘要：

  DOI：
• 作为产物：
  描述：

  naringenin 7,4'-dimethyl ether 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 2’,6’-二羟基-4,4’-二甲氧基二氢查耳酮
  参考文献：
  名称：

  Nilsson,M., Acta Chemica Scandinavica (1947), 1961, vol. 15, p. 154 - 158

  摘要：

  DOI：

文献信息

• KAMIYA, SHINTARO;ESAKI, SACHIKO;SHIBA, NAOKO;HOSHI, TAKESHI, AGR. AND BIOL. CHEM., 53,(1989) N, C. 1365-1373
  作者：KAMIYA, SHINTARO、ESAKI, SACHIKO、SHIBA, NAOKO、HOSHI, TAKESHI

  DOI：——

  日期：——
• GREENAWAY, W.;MAY, J.;WHATLEY, F. R., J. CHROMATOGR., 472,(1989) N, C. 393-400
  作者：GREENAWAY, W.、MAY, J.、WHATLEY, F. R.

  DOI：——

  日期：——
• GREENAWAY, W.;WHATLEY, F. R., J. CHROMATOGR., 519,(1990) N, C. 145-158
  作者：GREENAWAY, W.、WHATLEY, F. R.

  DOI：——

  日期：——
• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.
• NOX INHIBITOR AND NFkB INHIBITOR CONTAINING METHOXYFLAVONE
  申请人：SUNTORY HOLDINGS LIMITED

  公开号：US20170071902A1

  公开（公告）日：2017-03-16

  The present invention aims at providing NOX inhibitors and NFκB inhibitors having superior actions, as well as agents for preventing or treating NOX- or NFκB-associated diseases that utilize such inhibitors. To this end, specified methoxyflavones are employed.