阿普非农 | 124316-02-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 中文名称: 阿普非农
• 英文名称: Alprafenone
• 英文别名: 3-[3-[2-hydroxy-3-(2-methylbutan-2-ylamino)propoxy]-4-methoxyphenyl]-1-(4-methylphenyl)propan-1-one
• CAS: 124316-02-5
• 化学式: C₂₅H₃₅NO₄
• 分子量: 413.5
• InChiKey: WUUQBRHWNUFEEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] METHODS OF SYNTHESIZING N-HYDROXYSUCCINIMIDYL CARBONATES<br/>[FR] PROCÉDÉS DE SYNTHÈSE DE CARBONATES DE N-HYDROXYSUCCINIMIDYLE
  申请人：XENOPORT INC

  公开号：WO2010017498A1

  公开（公告）日：2010-02-11

  The present disclosure relates to methods of synthesizing N-hydroxysuccinimidyl-carbonate intermediates from the corresponding sulfones useful in the preparation of 1-(acyloxy)-alkyl carbamate prodrugs.

  本公开涉及一种从相应砜合成N-羟基琥珀酰亚胺-碳酸酯中间体的方法，该中间体在制备1-(酰氧基)-烷基氨甲酸酯前药中有用。
• METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS
  申请人：XENOPORT, INC.

  公开号：US20140243544A1

  公开（公告）日：2014-08-28

  Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

  提供了制备胺类药物的氨基甲酸酯前药的方法。还提供了在合成氨基甲酸酯前药中有用的碳酸盐。
• Pharmaceutical preparation comprising an active dispersed on a matrix
  申请人：——

  公开号：US20040058896A1

  公开（公告）日：2004-03-25

  The present invention relates to the field of pharmaceutical technology and describes a novel advantageous preparation for an active ingredient. The novel preparation is suitable for producing a large number of pharmaceutical dosage forms. In the new preparation an active ingredient is present essentially uniformly dispersed in an excipient matrix composed of one or more excipients selected from the group of fatty alcohol, triglyceride, partial glyceride and fatty acid ester.

  本发明涉及制药技术领域，描述了一种新的有利的活性成分制备方法。这种新的制备方法适用于生产大量的药物剂型。在这种新的制备方法中，活性成分基本上均匀地分散在由脂肪醇、甘油三酯、部分甘油酯和脂肪酸酯等多种赋形剂中选择的一种或多种赋形剂组成的赋形剂基质中。
• Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
  申请人：Gallop A. Mark

  公开号：US20050222431A1

  公开（公告）日：2005-10-06

  Methods for synthesis of 1 -(acyloxy)-alkyl carbamates, particularly, the synthesis of 1 -(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1 -(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1 -(acyloxy)-alkyl carbamates are also described.

  本文介绍了合成1-(酰氧基)-烷基氨基甲酸酯的方法，特别是合成含有一级或二级胺类药物的1-(酰氧基)-烷基氨基甲酸酯前药的方法。同时还介绍了合成1-(酰氧基)-烷基N-羟基琥珀酰亚胺碳酸酯的方法，这些化合物是合成1-(酰氧基)-烷基氨基甲酸酯的有用中间体。
• Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof
  申请人：Gallop Mark A.

  公开号：US20090216037A1

  公开（公告）日：2009-08-27

  Methods for synthesis of 1 -(acyloxy)-alkyl carbamates, particularly, the synthesis of 1 -(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1 -(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

  本文描述了合成1-(酰氧基)-烷基氨基甲酸酯的方法，特别是合成含有一级或二级胺药物的1-(酰氧基)-烷基氨基甲酸酯前药的方法。同时还描述了合成1-(酰氧基)-烷基N-羟基琥珀酰亚胺基碳酸酯的方法，这些中间体在合成1-(酰氧基)-烷基氨基甲酸酯中非常有用。