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水杨醛
二溴甲烷
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3',5'-O-(四异丙基二硅氧烷-1,3-二基)-2'-氧代尿苷 | 84828-97-7

分子结构分类

有机化合物 - 有机杂环化合物 - 二嗪类

中文名称

3',5'-O-(四异丙基二硅氧烷-1,3-二基)-2'-氧代尿苷

中文别名

——

英文名称

1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione

英文别名

3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-ketouridine；3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxane)-2'-oxouridine；1-[(6aR,8R,9aR)-9-oxo-2,2,4,4-tetra(propan-2-yl)-6a,9a-dihydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione

CAS

84828-97-7

化学式

C₂₁H₃₆N₂O₇Si₂

mdl

——

分子量

484.697

InChiKey

TWLMWUCVJNOKKT-NSISKUIASA-N

BEILSTEIN

——

EINECS

——

物化性质

熔点：

187 °C (decomp)
密度：

1.16±0.1 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

2.96
重原子数：

32
可旋转键数：

5
环数：

3.0
sp3杂化的碳原子比例：

0.76
拓扑面积：

103
氢给体数：

1
氢受体数：

7

安全信息

储存条件：

2-8℃

SDS

SDS：dce587c09d621d5b167e20d4fb575c8a

查看

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
3',5'-O-(1,1,3,3-四异丙基-1,3-二硅氧烷)尿苷	3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine	69304-38-7	C₂₁H₃₈N₂O₇Si₂	486.713
——	1-((2R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-2-phenylselanyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione	288103-32-2	C₂₇H₄₀N₂O₇SeSi₂	639.755
尿嘧啶核苷	uridine	58-96-8	C₉H₁₂N₂O₆	244.204

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	1-((2S,3aR,9aR)-2-Fluoro-5,5,7,7-tetraisopropyl-3-oxo-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione	899434-60-7	C₂₁H₃₅FN₂O₇Si₂	502.688
——	1-[4,6-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2,3-hexodiulofuranosyl]uracil	476490-32-1	C₂₂H₃₈N₂O₈Si₂	514.723
——	1-[(6aR,8R,9S,9aS)-9-hydroxy-2,2,4,4-tetraisopropyl-tetrahydro-6H-furo[3,2-f][1,3,5,2,4] trioxadisilocin-8-yl]-3H-pyrimidine-2,4-dione	104477-70-5	C₂₁H₃₈N₂O₇Si₂	486.713
——	1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione	102789-14-0	C₂₂H₃₈N₂O₆Si₂	482.725
——	1-((6a′R,8′R,9a′S)-2′,2′,4′,4′-tetraisopropyltetrahydrospiro[cyclopropane-1,9′-furo[3,2-f ][1,3,5,2,4]trioxadisilocin]-8′-yl)pyrimidine-2,4(1H,3H)-dione	140902-00-7	C₂₃H₄₀N₂O₆Si₂	496.751
——	(2Z)-2-[(6aR,8R,9aS)-8-(2,4-dioxopyrimidin-1-yl)-2,2,4,4-tetra(propan-2-yl)-6a,9a-dihydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-ylidene]acetonitrile	161258-54-4	C₂₃H₃₇N₃O₆Si₂	507.734
——	1-[2-C-(3-hydroxypropyl)-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil	664333-50-0	C₂₄H₄₄N₂O₈Si₂	544.793
——	1-[2-C-(2-hydroxyethyl)-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil	664333-56-6	C₂₃H₄₂N₂O₈Si₂	530.766
——	1-[2-C-(3-methanesulfonyloxypropyl)-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil	664333-51-1	C₂₅H₄₆N₂O₁₀SSi₂	622.885
——	1-[2-C-allyl-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil	664333-48-6	C₂₄H₄₂N₂O₇Si₂	526.778
——	1-((2R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-2-phenylselanyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione	288103-32-2	C₂₇H₄₀N₂O₇SeSi₂	639.755
——	1-[(6aR,8S,9aR)-9-oxo-8-phenylselanyl-2,2,4,4-tetra(propan-2-yl)-6a,9a-dihydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione	288103-31-1	C₂₇H₄₀N₂O₇SeSi₂	639.755
——	1-[2-C-(2-methanesulfonyloxyethyl)-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil	664333-57-7	C₂₄H₄₄N₂O₁₀SSi₂	608.858
——	(Z)-2'-deoxy-2'-ethoxycarbonylmethylene-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine	185556-78-9	C₂₅H₄₂N₂O₈Si₂	554.788
——	tert-butyl (2Z)-2-[(6aR,8R,9aS)-8-(2,4-dioxopyrimidin-1-yl)-2,2,4,4-tetra(propan-2-yl)-6a,9a-dihydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-ylidene]acetate	185556-73-4	C₂₇H₄₆N₂O₈Si₂	582.842
——	1-[2-O,2-C-propano-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil	664333-52-2	C₂₄H₄₂N₂O₇Si₂	526.778
——	1-[2-O,2-C-ethano-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil	664333-58-8	C₂₃H₄₀N₂O₇Si₂	512.751
——	1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-C-(trimethylsilyl)ethynyl-β-D-arabinofuranosyl>uracil	138481-66-0	C₂₆H₄₆N₂O₇Si₃	582.917
——	1-((6aR,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyl-9-((trimethylsilyl)ethynyl)tetrahydro-6H-furo[3,2-f ][1,3,5,2,4]-trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione	1610022-13-3	C₂₆H₄₆N₂O₇Si₃	582.917
——	1-<2-C-hexynyl-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl>uracil	138481-69-3	C₂₇H₄₆N₂O₇Si₂	566.842
——	1-[(6aR,8R,9R,9aS)-9-azido-9-methyl-2,2,4,4-tetra(propan-2-yl)-6,6a,8,9a-tetrahydrofuro[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione	1403249-85-3	C₂₂H₃₉N₅O₆Si₂	525.753
——	1-<2-C-(2-phenylethynyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl>uracil	114262-46-3	C₂₉H₄₂N₂O₇Si₂	586.833
——	1-[(2R)-2-deoxy-2-fluoro-3.5-O-(1,3-diyl)-1,1,3,3-tetraisopropyldisiloxane-2-C-trimethyl-silylethynyl-β-D-erythro-pentafuranosyl]uracile	1037071-74-1	C₂₆H₄₅FN₂O₆Si₃	584.908
——	1-<2-C-hexynyl-2-O-methoxalyl-3,5-O--β-D-arabino-pentofuranosyl>uracil	138481-71-7	C₃₀H₄₈N₂O₁₀Si₂	652.89
——	2-[(6aR,8R,9R,9aR)-8-(2,4-dioxopyrimidin-1-yl)-9-phenylsulfanyl-2,2,4,4-tetra(propan-2-yl)-6,6a,8,9a-tetrahydrofuro[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl]acetonitrile	161258-57-7	C₂₉H₄₃N₃O₆SSi₂	617.914
——	2-[(6aR,8R,9S,9aR)-8-(2,4-dioxopyrimidin-1-yl)-9-phenylsulfanyl-2,2,4,4-tetra(propan-2-yl)-6,6a,8,9a-tetrahydrofuro[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl]acetonitrile	161258-60-2	C₂₉H₄₃N₃O₆SSi₂	617.914
——	3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-methyleneuridine	134660-24-5	C₂₂H₄₀N₂O₅Si₂	468.741
——	1-[1-C-Phenylseleno-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribo-pentofuranosyl]uracil	288103-33-3	C₂₇H₄₂N₂O₇SeSi₂	641.771
——	1-[1-C-Phenylseleno-2-O-dimethylvinylsilyl-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribo-pentofuranosyl]uracil	357610-01-6	C₃₁H₅₀N₂O₇SeSi₃	725.964
——	(2Z)-2-[(2R,4S,5R)-2-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-5-[tri(propan-2-yl)silyloxymethyl]oxolan-3-ylidene]acetonitrile	180896-04-2	C₂₀H₃₁N₃O₅Si	421.569
——	[(2R,4S,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-triisopropylsilanyloxymethyl-dihydro-furan-(3E)-ylidene]-acetonitrile	181188-21-6	C₂₀H₃₁N₃O₅Si	421.569
——	1-((3aR,3bR,9aR,10aS)-5,5,7,7-Tetraisopropyl-2,2-dimethyl-1-phenylselanylmethyl-hexahydro-3,4,6,8,10-pentaoxa-2,5,7-trisila-cycloocta[a]pentalen-10a-yl)-1H-pyrimidine-2,4-dione	357610-05-0	C₃₁H₅₀N₂O₇SeSi₃	725.964
——	[(2R,4S,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-triisopropylsilanyloxymethyl-dihydro-furan-(3Z)-ylidene]-acetic acid ethyl ester	185556-81-4	C₂₂H₃₆N₂O₇Si	468.623
——	2-[(2R,3R,4R,5R)-2-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-phenylsulfanyl-5-[tri(propan-2-yl)silyloxymethyl]oxolan-3-yl]acetonitrile	180896-07-5	C₂₆H₃₇N₃O₅SSi	531.748
——	2-[(2R,3R,4R,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-2-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-phenylsulfanyloxolan-3-yl]acetonitrile	180896-08-6	C₂₃H₃₁N₃O₅SSi	489.668
——	[(3aS,9aR)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-9,9a-dihydro-3aH-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl]-acetonitrile	——	C₂₃H₃₇N₃O₆Si₂	507.734
——	1-((3aS,4R,6R,6aR)-2-Oxo-3a-phenylsulfanyl-6-triisopropylsilanyloxymethyl-hexahydro-furo[3,4-b]furan-4-yl)-1H-pyrimidine-2,4-dione	185556-84-7	C₂₆H₃₆N₂O₆SSi	532.733
——	[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-ethynyl-4-hydroxy-2-[[[[(2S)-1-oxo-1-propan-2-yloxypropan-2-yl]amino]-phenoxyphosphoryl]oxymethyl]oxolan-3-yl] 2-methylpropanoate	1610022-14-4	C₂₇H₃₄N₃O₁₁P	607.554
——	methyl (2S)-2-[[[(2R,3R,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-ethynyl-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate	1610022-18-8	C₂₁H₂₄N₃O₁₀P	509.409
——	1-((2R,3R,4R,5R)-3-ethynyl-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione	1037071-75-2	C₁₁H₁₁FN₂O₅	270.217
——	1-((2R,3S,4R,5R)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione	1051395-31-3	C₁₁H₁₂N₂O₆	268.226
——	1-((2R,3R,4R,5R)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione	——	C₁₁H₁₂N₂O₆	268.226
——	1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil	664333-54-4	C₃₃H₃₄N₂O₈	586.642
——	2'-deoxy-2'-difluoromethylene-5'-dimethoxytrityluridine	170112-35-3	C₃₁H₂₈F₂N₂O₇	578.569
——	1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-(prop-1-ynyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione	1443997-90-7	C₁₂H₁₄N₂O₆	282.253
——	1-[2-C-(propyn-1-yl)arabinofuranosyl]uracil	877652-72-7	C₁₂H₁₄N₂O₆	282.253
——	1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-ethano-β-D-arabinofuranosyl]uracil	664333-60-2	C₃₂H₃₂N₂O₈	572.615
——	(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-ethynyl-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate	1567899-65-3	C₂₃H₂₈N₃O₁₀P	537.463
——	1-[(4aR,6R,7R,7aR)-7-ethynyl-7-hydroxy-2-oxo-2-propan-2-yloxy-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidine-2,4-dione	1610022-58-6	C₁₄H₁₇N₂O₈P	372.271
——	2-[(2R,3R,4R,5R)-2-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)-3-phenylsulfanyloxolan-3-yl]acetonitrile	180896-09-7	C₁₇H₁₇N₃O₅S	375.405
——	(2'R)-2'-Deoxy-2'-ethynyl-2'-fluoro-4'-C-fluorouridine	1613591-01-7	C₁₁H₁₀F₂N₂O₅	288.208
——	methyl (2S)-2-[[[(2R,3R,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-ethynyl-4-hydroxy-3-[[[(2S)-1-methoxy-1-oxopropan-2-yl]amino]-phenoxyphosphoryl]oxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate	1610022-17-7	C₃₁H₃₆N₄O₁₄P₂	750.593
——	[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-ethynyl-2,4-difluoro-2-(hydroxymethyl)oxolan-3-yl] benzoate	1613591-00-6	C₁₈H₁₄F₂N₂O₆	392.316
——	1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-(3,3,3-trifluoroprop-1-ynyl)oxolan-2-yl]pyrimidine-2,4-dione	1610022-25-7	C₁₂H₁₁F₃N₂O₆	336.224
——	[3-¹³C]-1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-trideuteromethyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)dione	1256490-38-6	C₁₀H₁₄N₂O₆	262.196
——	(Z)-2'-(cyanomethylene)-2'-deoxyuridine	163011-97-0	C₁₁H₁₁N₃O₅	265.225
——	1-((5R,6R,8R,9S)-9-hydroxy-8-(hydroxymethyl)-7-oxa-1-azaspiro[4.4]nonan-6-yl)pyrimidine-2,4(1H,3H)-dione	1616262-02-2	C₁₂H₁₇N₃O₅	283.284
——	2'-deoxy-2'-methyleneuridine	119410-95-6	C₁₀H₁₂N₂O₅	240.216
——	1-[3-O-(2-cyanoethoxy)(diisopropylamino)phosphino-5-O-(4,4'-dimethoxytrityl)-2-O,2-C-ethano-β-D-arabinofuranosyl]uracil	——	C₄₁H₄₉N₄O₉P	772.835
——	1-(2'-C-methyl-β-D-arabinofuranosyl)uracil	114262-49-6	C₁₀H₁₄N₂O₆	258.231
——	2'-deoxy-2'(S)-ethynyl-uridine	138481-68-2	C₁₁H₁₂N₂O₅	252.227
——	1-[(5R,6R,8R,9S)-9-hydroxy-8-(hydroxymethyl)-2-oxo-7-oxa-1-azaspiro[4.4]nonan-6-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione	1616261-87-0	C₁₂H₁₅N₃O₆	297.268
——	[(2R,3S,4R,5R)-4-azido-5-(2,4-dioxopyrimidin-1-yl)-4-methyl-2-[[[[(2S)-1-oxo-1-propan-2-yloxypropan-2-yl]amino]-phenoxyphosphoryl]oxymethyl]oxolan-3-yl] 2-methylpropanoate	1403574-24-2	C₂₆H₃₅N₆O₁₀P	622.572
——	propan-2-yl (2S)-2-[[[(2R,3S,4R,5R)-4-azido-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate	1403574-66-2	C₂₂H₂₉N₆O₉P	552.481
(2'R)-2'-脱氧-2'-氟-2'-甲基脲苷	2'-deoxy-2'-fluoro-2'-methyluridine	863329-66-2	C₁₀H₁₃FN₂O₅	260.222
——	1-(2-O,2-C-propano-β-D-arabinofuranosyl)uracil	664333-53-3	C₁₂H₁₆N₂O₆	284.269
——	[3-¹³C]-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-trideuteromethyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)dione	1256490-42-2	C₁₀H₁₃FN₂O₅	264.187
——	1-(2-O,2-C-ethano-β-D-arabinofuranosyl)uracil	664333-59-9	C₁₁H₁₄N₂O₆	270.242
索氟布韦中间体 SF-C2	3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-2'-C-methyluridine	863329-65-1	C₂₄H₂₁FN₂O₇	468.438
——	1-[(2S,4aR,6R,7R,7aS)-7-azido-7-methyl-2-oxo-2-propan-2-yloxy-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidine-2,4-dione	1403250-84-9	C₁₃H₁₈N₅O₇P	387.289
——	1-[(2R,4aR,6R,7R,7aS)-7-azido-7-methyl-2-oxo-2-propan-2-yloxy-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidine-2,4-dione	1403250-85-0	C₁₃H₁₈N₅O₇P	387.289
——	1-[(4aR,6R,7R,7aS)-7-azido-7-methyl-2-oxo-2-propan-2-yloxy-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidine-2,4-dione	1403574-64-0	C₁₃H₁₈N₅O₇P	387.289
——	1-[(4aR,6R,7R,7aS)-7-azido-2-methoxy-7-methyl-2-oxo-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidine-2,4-dione	1403574-69-5	C₁₁H₁₄N₅O₇P	359.235
——	1-[(2R,3R,4S,5R)-3-azido-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione	1403249-86-4	C₁₀H₁₃N₅O₅	283.244
——	1-[(2S,4aR,6R,7R,7aS)-7-amino-7-methyl-2-oxo-2-propan-2-yloxy-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidine-2,4-dione	1403250-86-1	C₁₃H₂₀N₃O₇P	361.291
——	1-[(2R,4aR,6R,7R,7aS)-7-amino-7-methyl-2-oxo-2-propan-2-yloxy-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidine-2,4-dione	1403250-51-0	C₁₃H₂₀N₃O₇P	361.291
——	(Z)-2'-deoxy-2'-(ethoxycarbonylmethylene)uridine	163011-99-2	C₁₃H₁₆N₂O₇	312.279
——	[4-¹³C]-(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-trideuteromethyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate	1256490-44-4	C₂₂H₂₉FN₃O₉P	533.424
——	2'-deoxy-2'-C-β-methyluridine	151384-15-5	C₁₀H₁₄N₂O₅	242.232
——	2'-deoxy-2'-C-α-methyluridine	151384-13-3	C₁₀H₁₄N₂O₅	242.232
——	tert-butyl (2Z)-2-[(2R,4S,5R)-2-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-ylidene]acetate	185556-89-2	C₁₅H₂₀N₂O₇	340.333
——	[[(2R,3S,4R,5R)-4-azido-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	1403250-53-2	C₁₀H₁₆N₅O₁₄P₃	523.183
——	β-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate	1015073-42-3	C₁₀H₁₆FN₂O₁₄P₃	500.162
——	1-(2'-C-cyano-2'-deoxy-β-D-arabinofuranosyl)uracil	140859-13-8	C₁₀H₁₁N₃O₅	253.214
——	(2'S,5E)-5-(2-carboxyvinyl)-2'-deoxy-2'-C-methyluridine	175788-11-1	C₁₃H₁₆N₂O₇	312.279
——	(2'S,5E)-5-(2-carbomethoxyvinyl)-2'-deoxy-2'-C-methyluridine	175788-10-0	C₁₄H₁₈N₂O₇	326.306
——	(2'S)-5-iodo-2'-deoxy-2'-C-methyluridine	155372-63-7	C₁₀H₁₃IN₂O₅	368.128
——	(2'S)-2'-deoxy-5-ethynyl-2'-C-methyluridine	175788-07-5	C₁₂H₁₄N₂O₅	266.254
——	1-(2'-deoxy-2',2''-dideuterio-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione	114218-00-7	C₉H₁₂N₂O₅	230.189
——	(5R,6R,8R,9S)-6-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-9-hydroxy-8-(hydroxymethyl)-7-oxa-1-azaspiro[4.4]nonan-2-one	1616261-90-5	C₁₂H₁₆N₄O₅	296.283
——	1-[(2R,3R,4R)-3-ethynyl-3-fluoro-4-hydroxy-5-methylideneoxolan-2-yl]pyrimidine-2,4-dione	1613590-97-8	C₁₁H₉FN₂O₄	252.202

反应信息

作为反应物：

描述：

3',5'-O-(四异丙基二硅氧烷-1,3-二基)-2'-氧代尿苷在盐酸、羟胺作用下，以吡啶、乙醇为溶剂，生成 (2R,4R,5R,6R,8S)-5,7-dihydroxy-4-(hydroxymethyl)-6-methoxy-3-oxa-1,7,11-triazatricyclo[6.4.0.02,6]dodecane-10,12-dione

参考文献：

名称：

新型环核苷酸

摘要：

2'-脱氧-2'-羟基亚氨基尿苷衍生物的还原导致“第一代”羟胺（2'脱氧-2'-羟基氨基尿苷8，主要是阿拉伯构型），用醛处理后得到相应的硝酮9，将其还原为“第二代“羟胺” 12。所述修饰的核苷带有羟基的2'-位置，阿拉伯配置时进行共轭加成到尿嘧啶环导致新颖类型cyclonucleosides的（3，5，10，13）。

DOI：

10.1016/0040-4039(90)87026-v
作为产物：

描述：

尿嘧啶核苷在吡啶、乙酸酐、 pyridinium chlorochromate 作用下，以二氯甲烷为溶剂，生成 3',5'-O-(四异丙基二硅氧烷-1,3-二基)-2'-氧代尿苷

参考文献：

名称：

Synthesis of 2’-Modified Nucleotides

摘要：

我们在这项工作中展示了用于合成耐核酸酶的锤头核糖酶的改性构件的发展。这些改性单体保留了对这些分子活性至关重要的2’-OH。我们的最终目标是生成一种具有潜在基因治疗应用的催化反义方法。

DOI：

10.3390/50500727

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文献信息

[EN] 2'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES<br/>[FR] DÉRIVÉS DE NUCLÉOSIDE 2'-SUBSTITUÉS ET PROCÉDÉS D'UTILISATION DE CEUX-CI POUR LE TRAITEMENT DE MALADIES VIRALES

申请人：MERCK SHARP & DOHME

公开号：WO2012142085A1

公开（公告）日：2012-10-18

The present invention relates to 2'-Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2'-Substituted Nucleoside Derivative, and methods of using the 2'-Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

本发明涉及式(I)的2'-取代核苷衍生物及其药学上可接受的盐，其中A、B、X、R1、R2和R3如本文所定义。本发明还涉及包含至少一种2'-取代核苷衍生物的组合物，以及使用这些2'-取代核苷衍生物治疗或预防患者HCV感染的方法。
2'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

申请人：Girijavallabhan Vinay

公开号：US20140206640A1

公开（公告）日：2014-07-24

The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R 1 , R 2 and R 3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

本发明涉及式(I)的2'-叠氮基取代核苷衍生物及其药学上可接受的盐，其中B、X、R1、R2和R3如本文所定义。本发明还涉及包含至少一种2'-叠氮基取代核苷衍生物的组合物，以及使用这些2'-叠氮基取代核苷衍生物治疗或预防患者HCV感染的方法。
[EN] NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO<br/>[FR] COMPOSITIONS THÉRAPEUTIQUES À BASE DE NUCLÉOTIDES ET NUCLÉOSIDES ET UTILISATIONS ASSOCIÉES

申请人：UNIV EMORY

公开号：WO2017155923A1

公开（公告）日：2017-09-14

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

这份披露涉及到核苷酸和核苷类治疗组合物，用于治疗传染病、病毒感染和癌症，在这些组合物中，核苷酸或核苷的碱基至少含有一个硫醇、硫酮或硫醚。
[EN] ALKYNE CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO<br/>[FR] COMPOSITIONS THÉRAPEUTIQUES À BASE DE NUCLÉOTIDES ET NUCLÉOSIDES CONTENANT UN ALCYNE ET UTILISATIONS ASSOCIÉES

申请人：UNIV EMORY

公开号：WO2017189978A1

公开（公告）日：2017-11-02

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

这份披露涉及到核苷酸和核苷类治疗组合物，用于治疗传染病、病毒感染和癌症，其中核苷酸或核苷的碱基至少含有一个硫醇、硫酮或硫醚。
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

申请人：Alios BioPharma, Inc.

公开号：US20150105341A1

公开（公告）日：2015-04-16

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, nucleotides and nucleotide analogs.

本文披露了核苷、核苷酸和核苷酸类似物，以及它们的合成方法以及利用一个或多个核苷、核苷酸和核苷酸类似物治疗如小核糖核病毒和/或黄病毒科感染等疾病和/或症状的方法。