3,26-二羟基羊毛甾-8,24-二烯-7-酮 | 252351-95-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3,26-二羟基羊毛甾-8,24-二烯-7-酮
• 英文名称: Lucidadiol
• 英文别名: (3S,5R,10S,13R,14R,17R)-3-hydroxy-17-[(E,2R)-7-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-1,2,3,5,6,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-7-one
• CAS: 252351-95-4
• 化学式: C₃₀H₄₈O₃
• 分子量: 456.7
• InChiKey: AZPOACUDFJKUHJ-GPEQXWBKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACIDS
  申请人：ModernaTX, Inc.

  公开号：EP3852814A1

  公开（公告）日：2021-07-28
• EMBRYONIC EGG EXTRACT COMPOSITION
  申请人：Siripanich Nitit

  公开号：US20180027853A1

  公开（公告）日：2018-02-01

  A composition of avian embryonic egg extract, panax Ginseng, and Ganoderma lingzhi extract is provided which may help to restore damaged cells, repair damaged body tissues, delay cellular deterioration, and inhibit free radicals,
• Genetically-Modified Bacteria And Uses Thereof
  申请人：Cambrex Karlskoga AB

  公开号：US20210317502A1

  公开（公告）日：2021-10-14

  A genetically-modified bacterium, for example of the class Actinobacteria, and the use of such a bacterium in the bioconversion of a steroidal substrate into a steroidal product of interest. A method of converting a steroidal substrate into a steroidal product of interest, wherein the method comprises: inoculating culture medium with genetically-modified bacteria according to any of Claims 1 to 28 and growing the bacterial culture until a target OD 600 is reached; adding a steroidal substrate to the bacterial culture when the target OD 600 is reached; culturing the bacterial culture so that the steroidal substrate is converted to the steroidal product of interest; and extracting and/or purifying the steroidal product of interest from the bacterial culture.
• [EN] COMPOSITIONS COMPRISING COMPOSITE NANOCARRIERS AND METHODS OF MAKING AND USES THEREOF<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
  申请人：UNIV TEXAS

  公开号：WO2017147407A1

  公开（公告）日：2017-08-31

  Disclosed herein are compositions comprising an aqueous solution comprising a composite nanocarrier, the composite nanocarrier comprising a nanoparticle at least partially encapsulated within a vesicle, the vesicle comprising a sterol and a surfactant. In some examples, the vesicle consists of a sterol and a surfactant. In some examples, the sterol comprises cholesterol or a derivative thereof. In some examples, the surfactant comprises a quaternary ammonium surfactant, such as cetyl trimethylammonium bromide. In some examples, the nanoparticle comprises Si. The compositions described herein can be substantially stable. Also disclosed herein are methods of making and methods of use of the composition disclosed herein.
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACIDS<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：MODERNATX INC

  公开号：WO2020061397A1

  公开（公告）日：2020-03-26

  The present disclosure relates to methods and compositions for modulating protein expression. In particular, the invention features methods and compositions for increasing protein expression in a cell by delivering to the cell a composition including an mRNA encoding a polypeptide and one or more oligonucleotides, wherein each of the one or more oligonucleotides includes a region of linked nucleotides complimentary to a portion of the sequence of the mRNA. The methods and compositions described herein may be used to modulate gene expression (e.g., increase gene expression), to increase the stability of the mRNA, to decrease the immunogenicity of the mRNA, to enable selective expression (e.g., in a target cell or tissue) of the mRNA, and/or to enable the delivery of two or more mRNAs in a stoichiometric ratio.