28-Amino-β-amyrin | 39668-13-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 28-Amino-β-amyrin
• 英文别名: (3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(aminomethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-ol；28-amino-olean-12-en-3β-ol；(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(aminomethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol
• CAS: 39668-13-8
• 化学式: C₃₀H₅₁NO
• 分子量: 441.741
• InChiKey: CKMMSMKWJRIBOT-OSQDELBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  32
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  28-Amino-β-amyrin 在 palladium diacetate 、 sodium carbonate 、 三乙胺 、 间氯过氧苯甲酸 、 2-碘酰基苯甲酸 作用下， 以 氟苯 、 二氯甲烷 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 54.0h， 生成 tert-butyl (((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicen-4a(2H)-yl)methyl)carbamate
  参考文献：
  名称：

  WO2020068689A5

  摘要：

  公开号：

  WO2020068689A5
• 作为产物：
  描述：

  3-acetyl oleanolic acid chloride 在 ammonium hydroxide 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 28-Amino-β-amyrin
  参考文献：
  名称：

  齐墩果酸衍生物的合成及其抗HIV活性。

  摘要：

  制备了十三种齐墩果酸衍生物，并评估了其在H9淋巴细胞中的抗HIV活性。饱和C（12）-C（13）双键并将C（17）-羧基转化为氨甲基导致化合物13-15和19-20分别显示出改进的抗HIV活性。化合物15是最有效的衍生物，EC（50）= 0.0039 microg / mL，TI = 3570。

  DOI：

  10.1016/s0960-894x(01)00647-3

文献信息

• Synthese einiger stickstoffhaltiger β-Amyrinderivate
  作者：Hermann Linde、Gisela Cramer

  DOI：10.1002/ardp.19853180216

  日期：——
• Wrzeciono; Malecki; Budzianowski, Pharmazie, 1985, vol. 40, # 8, p. 542 - 544
  作者：Wrzeciono、Malecki、Budzianowski、Kierylowicz、Zaprutko、Beimcik、Kostepska

  DOI：——

  日期：——
• Free hemoglobin concentrations in patients receiving massive blood transfusion during emergency surgery for trauma
  作者：Tomoki Nishiyama、Kazuo Hanaoka

  DOI：10.1007/bf03019668

  日期：2000.9

  Purpose: To determine free hemoglobin concentration in patients who received massive blood transfusion during emergency surgery for trauma with consideration of the storage of the transfused blood.Methods: Fifteen patients undergoing emergency surgery for multiple trauma and who received blood transfusion of more than 5,000 mt were studied. Transfusion of the stored whole blood in citrate-phosphate glucose solution using a micropore filter was started before surgery. Serum concentrations of hemoglobin (total:THb and free:fHb) and total haptoglobin (THp) were measured until 5,000 mt of blood had been transfused. Serum free haptoglobin (fHp) concentration was calculated. The correlation between the changes in hemoglobin or haptoglobin concentrations and total storage days of the transfused blood was analyzed by a simple regression analysis.Results: Free hemoglobin was detected after 2,000 mt transfusion. The THp and fHp decreased after 1,000 mt transfusion. Total storage time (days) of transfused blood had correlated with the changes of THp (P < 0.0001) and fHp (P = 0.0027) but not with the changes of THb (P = 0.984) and fHb (P = 0.834).Conclusion: After blood transfusion during surgery for trauma, serum haptoglobin concentration decreased with transfusion of greater than or equal to 1,000 mt of whole blood with mean storage time of 12.2 dy. Free hemoglobin was detected after 2,000 mt transfusion when THp decreased to 1,000 mg L-l. Serum haptoglobin concentrations correlated negatively with storage time (days) of transfused blood.
• WRZECIONO, URSZULA;BUDZIANOWSKI, JAROMIR;KIERYLOWICZ, HANNA;MALECKI, IGNA+
  作者：WRZECIONO, URSZULA、BUDZIANOWSKI, JAROMIR、KIERYLOWICZ, HANNA、MALECKI, IGNA+

  DOI：——

  日期：——
• WRZECIONO, URSZULA;ZAPRUTKO, LUCJUSZ;BUDZIANOWSKI, JAROMIR;MALECKI, IGNAC+
  作者：WRZECIONO, URSZULA、ZAPRUTKO, LUCJUSZ、BUDZIANOWSKI, JAROMIR、MALECKI, IGNAC+

  DOI：——

  日期：——