4-肼基-8-甲基喹啉 | 68500-35-6

• 物质功能分类: 有机原料 - 肼或胲的有机衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-肼基-8-甲基喹啉
• 英文名称: 4-hydrazino-8-methyl-quinoline
• 英文别名: 8-Methyl-chinol-4-ylhydrazin；4-Hydrazinyl-8-methylquinoline；(8-methylquinolin-4-yl)hydrazine
• CAS: 68500-35-6
• 化学式: C₁₀H₁₁N₃
• 分子量: 173.217
• InChiKey: SUSYTHMNOJICKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  4-肼基-8-甲基喹啉 在 三乙胺 、 肼 作用下， 以 四氢呋喃 、 二乙二醇 为溶剂， 反应 9.0h， 生成 4-methyl-N-(2-methyl-6-{1-[(4-methylphenyl)sulfonyl]-1Hpyrazol-3-yl}phenyl)benzenesulfonamide
  参考文献：
  名称：

  Synthesis andin vitroEvaluation of New Benzenesulfonamides as Antileishmanial Agents

  摘要：

  This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.

  DOI：

  10.5935/0103-5053.20140062
• 作为产物：
  描述：

  4-羟基-8-甲基喹啉 在 肼 、 三氯氧磷 作用下， 以 二乙二醇 为溶剂， 反应 25.0h， 生成 4-肼基-8-甲基喹啉
  参考文献：
  名称：

  Synthesis andin vitroEvaluation of New Benzenesulfonamides as Antileishmanial Agents

  摘要：

  This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.

  DOI：

  10.5935/0103-5053.20140062

文献信息

• KHAN M. A.; ROCHA J. F. DA, J. HETEROCYCL. CHEM., 1978, 15, NO 6, 913-921
  作者：KHAN M. A.、 ROCHA J. F. DA

  DOI：——

  日期：——
• Synthesis and<i>in vitro</i>Evaluation of New Benzenesulfonamides as Antileishmanial Agents
  作者：Julio C. Borges、Adriana V. Carvalho、Alice M. R. Bernardino、César D. Oliveira、Luiz C. S. Pinheiro、Roberta K. F. Marra、Helena C. Castro、Solange M. S. V. Wardell、James L. Wardell、Veronica F. Amaral、Marilene M. Canto-Cavalheiro、Leonor L. Leon、Marcelo Genestra

  DOI：10.5935/0103-5053.20140062

  日期：——

  This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.