dodecane-2,4-dione | 65351-33-9

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dodecane-2,4-dione
• 英文别名: Dodeca-2,4-dione；Dodecan-2,4-dion；Nonoylaceton；2,4-dodecanedione
• CAS: 65351-33-9
• 化学式: C₁₂H₂₂O₂
• 分子量: 198.305
• InChiKey: PGCYJKDJSLVDGX-UHFFFAOYSA-N

物化性质

• 沸点：
  150 °C(Press: 14 Torr)
• 密度：
  0.8887 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dodecane-2,4-dione 在 ammonium cerium(IV) nitrate 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以78%的产率得到壬酸
  参考文献：
  名称：

  β-二酮和β-酮​​酸酯轻度转化为羧酸

  摘要：

  描述了在CAN 3 CN中使用CAN将β-酮酸酯和β-二酮转化为羧酸的温和方案。该方法与许多官能团相容，并且可以在室温下在中性条件下生成羧酸。该反应快速且通用，为常用的丙二酸酯制备提供了另一种方法。初步的机理研究表明，β-二羰基烯醇形式的初始氧化可引发反应。硝酸盐作为氧化剂的配体或添加剂的存在对于反应成功至关重要。

  DOI：

  10.1021/jo0602975
• 作为产物：
  描述：

  乙酸异丙烯酯 、 2-癸酮 在 硫酸 作用下， 生成 dodecane-2,4-dione
  参考文献：
  名称：

  Lateral Stability During Forward-Induced Stepping for Dynamic Balance Recovery in Young and Older Adults

  摘要：

  Background. Balance dysfunction related to lateral instability has been associated with falls and fall-related injuries among older individuals. Protective stepping for dynamic balance recovery requires the effective control of lateral body motion, This study investigated the relationship between aging, falls, and lateral stability during forward-induced stepping for dynamic balance recovery.Methods. Forward steps were induced by a motor-driven waist-pull system in 12 younger adults, 20 healthy community-dwelling older adult nonfallers, and IS older adults who had reported falls. Group differences in kinetic and kinematic stepping characteristics for a range of Postural disturbance magnitudes were evaluated.Results. Despite group similarities in anticipatory postural adjustments for minimizing lateral instability, the older fallers demonstrated significantly greater sideways body motion toward the stepping side at first-step foot contact and a more laterally directed foot placement. During the first step, forward-stepping characteristics were generally comparable between the groups, but the older falters had an earlier liftoff time and longer step duration.Conclusions. During forward-induced protective stepping, otherwise healthy older adults who had experienced falls showed particular differences in their control of lateral body motion that were not attributable to changes in anticipatory postural mechanisms. Aging changes in controlling lateral body motion during protective stepping appear to involve factors that intervene between the first-step liftoff and foot contact and/or adaptations in stepping patterns related to prior planning.

  DOI：

  10.1093/gerona/56.9.m589

文献信息

• Design and synthesis of analogues of ionomycin
  作者：Thomas Q. Hu、Larry Weller

  DOI：10.1139/v94-187

  日期：1994.6.1

  Based on the analysis of the crystal structure of the Ca²⁺ salt of ionomycin and the chemical and physical data on ionomycin, a number of ionomycin analogues have been synthesized to study the structural features affecting the Ca²⁺ binding and transport. Compounds 2, 3, and 4 were synthesized to study the effect of additional intramolecular oxygen coordination sites on Ca²⁺ transport. Compounds 5a–5d were prepared to study the effect of lipid solubility on Ca²⁺ binding and transport. Compounds 6a–6c were prepared to study the effect of the distance between the β-diketone and the carboxyl group on Ca²⁺ transport. A general synthetic route to these compounds has been developed. The key reactions in this route are the consecutive regioselective alkylations of the dianion of 2,4-pentanedione with the appropriate bromides.[Formula: see text]

  根据对离子霉素（ionomycin）的Ca²⁺盐的晶体结构分析以及对离子霉素的化学和物理数据，合成了许多离子霉素类似物以研究影响Ca²⁺结合和传输的结构特征。化合物2、3和4被合成用于研究额外的分子内氧配位位点对Ca²⁺传输的影响。化合物5a–5d被制备用于研究脂溶性对Ca²⁺结合和传输的影响。化合物6a–6c被制备用于研究β-二酮和羧基之间距离对Ca²⁺传输的影响。已经开发了这些化合物的一般合成路线。该路线中的关键反应是对2,4-戊二酮的二阴离子进行连续的区域选择性烷基化反应，使用适当的溴化物。
• FIELD EFFECT TRANSISTOR
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20160035457A1

  公开（公告）日：2016-02-04

  There is provided a field effect transistor which comprises a gate insulating layer, a gate electrode, a semiconductor layer, a source electrode and a drain electrode. The gate insulating layer contains an organic compound that contains a silicon-carbon bond and a metal compound that contains a bond between a metal atom and an oxygen atom; and the metal atoms are contained in the gate insulating layer in an amount of 10 to 180 parts by weight with respect to 100 parts by weight of the total of carbon atoms and silicon atoms. This field effect transistor (FET) has high mobility and a low voltage of the threshold value, while being suppressed in leak current.

  提供了一种场效应晶体管，包括栅绝缘层、栅电极、半导体层、源极电极和漏极电极。栅绝缘层包含一种含有硅碳键的有机化合物和一种含有金属原子和氧原子之间键的金属化合物；金属原子在栅绝缘层中的含量为100份碳原子和硅原子的总重量中的10至180份重量。该场效应晶体管具有高迁移率和低阈值电压，同时抑制泄漏电流。
• ARTICLE WITH ANTIFOULING PROPERTIES, INTENDED FOR AQUATIC USES AND, IN PARTICULAR, FOR MARINE USES
  申请人：BLUESTAR SILICONES FRANCE SAS

  公开号：US20150329724A1

  公开（公告）日：2015-11-19

  The invention relates to an article with antifouling properties, intended for aquatic uses and, in particular, for marine uses, and to a method for slowing down the growth of aquatic organisms on submersible or semi-subermisible structures.

  本发明涉及一种具有防污性能的物品，用于水生环境，特别是海洋环境，并且涉及一种减缓水生生物在潜水或半潜水结构上生长的方法。
• ORGANOPOLYSILOXANE COMPOSITION SUITABLE FOR VULCANISATION INTO AN ELASTOMER AT ROOM TEMPERATURE AND NEW ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS
  申请人：BLUESTAR SILICONES FRANCE SAS

  公开号：US20150322235A1

  公开（公告）日：2015-11-12

  The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to several novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.

  本发明涉及用于免疫治疗方法的肽、核酸和细胞。特别地，本发明涉及癌症的免疫治疗。此外，本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，单独或与其他肿瘤相关肽表位结合，作为刺激抗肿瘤免疫反应的疫苗组分的活性药物成分。本发明涉及几种新的肽序列及其变异体，这些序列来自人类肿瘤细胞的HLA I类和HLA II类分子，可用于制备疫苗组分，以引发抗肿瘤免疫反应。
• Rectifying element, method for producing same, and wireless communication device
  申请人：TORAY INDUSTRIES, INC.

  公开号：US10490748B2

  公开（公告）日：2019-11-26

  There is provided a rectifying element which is provided with an insulating base, (a) a pair of electrodes composed of a first electrode and a second electrode and (b) a semiconductor layer arranged between the pair of electrodes, wherein the components (a) and (b) are provided on a first surface of the insulating base. The rectifying element is configured such that the semiconductor layer (b) contains carbon nanotube composites each of which comprises a carbon nanotube and a conjugated polymer adhered onto at least a part of the surface of the carbon nanotube. The present invention provides a rectifying element having excellent rectifying properties by a simple process.

  提供了一种整流元件，它具有绝缘基座、(a) 一对由第一电极和第二电极组成的电极和 (b) 设置在这对电极之间的半导体层，其中组件 (a) 和 (b) 设置在绝缘基座的第一表面上。整流元件被配置成半导体层（b）包含碳纳米管复合材料，每个碳纳米管复合材料包括碳纳米管和粘附在碳纳米管表面至少一部分的共轭聚合物。本发明通过简单的工艺提供了一种具有优异整流特性的整流元件。