乙基九氟代丁基醚 | 163702-05-4

• 物质功能分类: 有机原料 - 醚类化合物及其衍生物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 乙基九氟代丁基醚
• 中文别名: 乙基全氟异丁基醚；乙基九氟丁基醚；乙基全氟丁基醚
• 英文名称: 1-(Ethoxy)nonafluorobutane
• 英文别名: 1-ethoxy-1,1,2,2,3,3,,4,4,4-nonafluorobutane；4-ethoxy-1,1,1,2,2,3,3,4,4-nonafluorobutane；ethyl perfluorobutyl ether；perfluorobutyl ethyl ether；1-ethoxynonafluorobutane；n-HFE-7200；1-ethoxy-1,1,2,2,3,3,4,4,4-nonafluorobutane
• CAS: 163702-05-4
• 化学式: C₆H₅F₉O
• mdl: MFCD01862062
• 分子量: 264.091
• InChiKey: DFUYAWQUODQGFF-UHFFFAOYSA-N

物化性质

• 熔点：
  -138 °C (lit.)
• 沸点：
  76 °C (lit.)
• 密度：
  1.428 g/mL at 25 °C (lit.)
• 闪点：
  39 °F
• 最大波长(λmax)：
  λ: 220 nm Amax: 1.0λ: 225 nm Amax: 0.35λ: 250 nm Amax: 0.05λ: 300-400 nm Amax: 0.01

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  10

安全信息

• TSCA：
  T
• 危险品标志：
  Xn,F
• 危险类别码：
  R11
• 危险品运输编号：
  UN 1993 3/PG 2
• WGK Germany：
  3
• 安全说明：
  S16,S23,S45

反应信息

• 作为反应物：
  描述：

  乙基九氟代丁基醚 在 hydroxide 作用下， 以 氯仿 为溶剂， 生成 C₆H₄F₉O₃
  参考文献：
  名称：

  Atmospheric Chemistry of HFE-7200 (C₄F₉OC₂H₅):  Reaction with OH Radicals and Fate of C₄F₉OCH₂CH₂O(•) and C₄F₉OCHO(•)CH₃ Radicals

  摘要：

  Relative rate techniques were used to measure k(OH + n-C4F9OC2H5) = (6.4 +/- 0.7) x 10(-14) and k(OH + i-C4F9OC2H5) = (7.7 +/- 0.8) x 10(-14) cm(3) molecule(-1) s(-1) at 295 K leading to estimates of approximate to 0.9 and 0.7 years for the atmospheric lifetimes of n-C4F9OC2H5 and i-C4F9OC2H5, respectively. A pulse radiolysis technique was used to measure k(F + HFE-7200) = (5.6 +/- 2.1) x 10(-11) cm(3) molecule(-1) s(-1) (HFE-7200 = C4F9OC2H5) at 296 K. Using FTIR-smog chamber relative rate techniques the following rate constants were determined at 296 K: k(F + HFE-7200) = (5.5 +/- 1.1) x 10(-11), k(Cl + HFE-7200) = (2.7 +/- 0.6) x 10(-12) and k(Cl + C4F9OC(O)CH3) < 7 x 10(-13) cm(3) molecule(-1) s(-1). Two competing loss mechanisms for C4F9OCHO(.)CH3 radicals were identified in 700 Torr of N-2/O-2 diluent at 296 K; reaction with O-2 and decomposition via C-C bond scission with k(O2)/k(decomp) = 0.026 +/- 0.010 Torr(-1). The Cl atom initiated oxidation of HFE-7200 in N-2/O-2 diluent gives two products: C4F9OC(O)CH3 and C4F9OC(O)H. C4F9OC(O)CH3 is the major atmospheric oxidation product of HFE-7200; C4F9OC(O)H is a minor product. The results are discussed with respect to the atmospheric chemistry of hydrofluoroethers.

  DOI：

  10.1021/jp981128u
• 作为试剂：
  描述：

  [(2R,3R,4R,5R)-5-azido-2-(azidomethyl)-4-phenylmethoxy-6-phenylsulfanyloxan-3-yl] acetate 、 2-[3-[3-[4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecanoyl(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)amino]propanoyl-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)amino]propanoyl-[2-[3-[3-[4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecanoyl(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)amino]propanoyl-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)amino]propanoylamino]ethyl]amino]ethyl 2-[[4-[2-[(3R,4R,5R,6R)-3-azido-6-(azidomethyl)-5-hydroxy-4-phenylmethoxyoxan-2-yl]oxyethylcarbamoyloxymethyl]benzoyl]amino]acetate 、 甲醇 在 N-碘代丁二酰亚胺 、 三氟甲磺酸 、 sodium methylate 、 乙基九氟代丁基醚 作用下， 以 二氯甲烷 为溶剂， 以13%的产率得到methyl 2-[[4-[2-[(2S,3R,4R,5R,6R)-3-azido-5-[(2R,3R,4R,5R,6R)-3-azido-6-(azidomethyl)-5-hydroxy-4-phenylmethoxyoxan-2-yl]oxy-6-(azidomethyl)-4-phenylmethoxyoxan-2-yl]oxyethylcarbamoyloxymethyl]benzoyl]amino]acetate
  参考文献：
  名称：

  Synthesis of aminoglycoside derivatives on a Cbz-type heavy fluorous tag

  摘要：

  Four aminoglycoside derivatives containing a 2,6-diamino-2,6-dideoxy-D-glucopyranose disaccharide structure were successfully prepared by using a Cbz-type heavy fluorous tag in a fluorous synthesis. A Cbz-type heavy fluorous tag was prepared using the hexakis(fluorous chain)-type alcohol 11, and the fluorous alcohol 11 was recovered in good yield after the synthesis of aminoglycoside derivatives. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.064

文献信息

• Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
  申请人：Failli A. Amedeo

  公开号：US20060199806A1

  公开（公告）日：2006-09-07

  This invention provides pyrrolobenzodiazepine arylcarboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists, as well as pharmaceutical compositions and methods of treatment

  这项发明提供了从式（1）中选择的吡咯苯并二氮杂环芳基甲酰胺，其作为促卵泡生成激素受体拮抗剂，以及药物组合物和治疗方法。
• [EN] ANTIBACTERIAL COMPOSITION INCLUDING BENZOIC ACID ESTER AND METHODS OF INHIBITING BACTERIAL GROWTH UTILIZING THE SAME<br/>[FR] COMPOSITION ANTIBACTÉRIENNE COMPRENANT UN ESTER D'ACIDE BENZOÏQUE ET PROCÉDÉS D'INHIBITION DE LA CROISSANCE BACTÉRIENNE UTILISANT CELLE-CI
  申请人：KIMBERLY CLARK CO

  公开号：WO2018143911A1

  公开（公告）日：2018-08-09

  Antibacterial compositions and methods for inhibiting bacterial growth are disclosed. The antibacterial compositions can include a carrier and an antibacterial agent including a benzoic acid ester. The benzoic acid ester can have a carbon chain having a length of two to ten. The benzoic acid ester can have a hydroxyl group on the carbon chain.

  抗菌组合物和抑制细菌生长的方法被披露。抗菌组合物可以包括载体和包括苯甲酸酯的抗菌剂。苯甲酸酯的碳链长度可以为二至十。苯甲酸酯的碳链上可以有一个羟基。
• [EN] ACRYLATE-FUNCTIONAL BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ À FONCTION ACRYLATE, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
  申请人：DOW SILICONES CORP

  公开号：WO2020142474A1

  公开（公告）日：2020-07-09

  A method of preparing an acrylate-functional branched organosilicon compound ("compound") is provided, and comprises reacting (A) a branched organosilicon compound and (B) an acrylate compound in the presence of (C) a catalyst, wherein component (A) has the general formula X-Si(R1)3, where X comprises a halogen-functional moiety and each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; each R4 is selected from R, –OSi(R5)3, and –[OSiR2]mOSiR3; each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; each R6 is selected from R and –[OSiR2]mOSiR3; each R is an independently selected hydrocarbyl group; and 0≤m≤100; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3. The compound prepared by the method, a copolymer comprising the reaction product of the compound and a second compound, a method of forming the copolymer, and a composition comprising the copolymer are each also provided.

  提供了一种制备丙烯酸酯官能化分支有机硅化合物（“化合物”）的方法，包括在催化剂存在下，使（A）分支有机硅化合物和（B）丙烯酸酯化合物发生反应，其中组分（A）具有一般式X-Si（R1）3，其中X包括卤素官能基，每个R1从R和–OSi（R4）3中选择，但至少一个R1为–OSi（R4）3；每个R4从R、–OSi（R5）3和–[OSiR2]mOSiR3中选择；每个R5从R、–OSi（R6）3和–[OSiR2]mOSiR3中选择；每个R6从R和–[OSiR2]mOSiR3中选择；每个R是独立选择的烃基；且0≤m≤100；但至少一个R4、R5和R6为–[OSiR2]mOSiR3。还提供了通过该方法制备的化合物，包括化合物和第二化合物的反应产物的共聚物，形成共聚物的方法，以及包含共聚物的组合物。
• Separation of fluorous compounds
  申请人：Curran P. Dennis

  公开号：US20050283032A1

  公开（公告）日：2005-12-22

  A method of separating at least a first non-fluorous compound from a mixture of compounds including at least the first non-fluorous compound and a second fluorous compound includes: charging the of compounds to a non-fluorous solid (stationary) phase and eluting with a fluorous eluting fluid (mobile phase). In one embodiment, the non-fluorous solid phase is polar in nature. The method can further include a second phase elution with a suitable organic solvent. A method conducting a chemical reaction, includes: mixing at least a first fluorous compound and a second compound, the first fluorous compound differing in fluorous nature from the second compound; exposing the first mixture to conditions to convert at least one of the first fluorous compound and the second compound to give a second mixture containing at least a third compound, charging the second mixture to a non-fluorous solid phase; and eluting with a fluorous fluid

  将至少一个非氟化合物从包括至少第一个非氟化合物和第二个氟化合物的混合物中分离出来的方法包括：将化合物充电到非氟固体（静态）相，并用氟溶剂流体（移动相）洗脱。在一个实施例中，非氟固相具有极性特性。该方法还可以包括使用适当的有机溶剂进行第二相洗脱。一种进行化学反应的方法包括：混合至少一个第一氟化合物和第二化合物，第一个氟化合物在氟性质上与第二化合物不同；将第一混合物暴露在条件下，将至少一个第一个氟化合物和第二化合物转化为至少包含第三化合物的第二混合物，将第二混合物充电到非氟固相；并用氟溶剂洗脱。
• [EN] MICROFLUIDIC PRODUCTION OF BIOFUNCTIONALIZED GIANT UNILAMELLAR VESICLES FOR TARGETED CARGO DELIVERY<br/>[FR] PRODUCTION MICROFLUIDIQUE DE VÉSICULES UNILAMELLAIRES GÉANTES BIOFONCTIONNALISÉES POUR UNE DISTRIBUTION DE CHARGE CIBLÉE
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2021123399A1

  公开（公告）日：2021-06-24

  The present invention relates to a method for preparation of monodisperse cell- targeting giant unilamellar vesicles based on symmetrically division of a parent polymer shell-stabilized giant unilamellar vesicle into smaller polymer shell- stabilized giant unilamellar vesicles with a diameter between 1 µm and 10 µm using a microfluidic splitting device. The inventive method allows preparation of differently charged giant unilamellar vesicles as well as bioligand- and PEG-conjugated giant unilamellar vesicles, which are useful for targeted cellular delivery at high efficiency and specificity. A further advantage of the present invention is that the giant unilamellar vesicles can deliver huge cargos such as drug releasing porous microparticles, high amounts of in vivo imaging probes, viruses, or up-and-coming DNA origami robots.

  本发明涉及一种制备单分散细胞靶向巨大单层泡囊的方法，该方法基于将母体聚合物壳稳定的巨大单层泡囊对称分裂成直径在1微米至10微米之间的较小聚合物壳稳定的巨大单层泡囊，使用微流体分裂装置。这种创新的方法允许制备带有不同电荷的巨大单层泡囊，以及生物配体和PEG共轭的巨大单层泡囊，这对于高效和特异性的靶向细胞传递非常有用。本发明的另一个优点是，巨大单层泡囊可以传递大量的货物，例如释放药物的多孔微粒、大量体内成像探针、病毒或即将推出的DNA折纸机器人。