N-（3-氯-4-氟苯基）-7-甲氧基-6-氨基喹唑啉-4-胺 | 179552-75-1

物质功能分类

有机原料 - 酮类化合物

分子结构分类

有机化合物 - 有机杂环化合物 - 二氮杂萘

中文名称

N-（3-氯-4-氟苯基）-7-甲氧基-6-氨基喹唑啉-4-胺

中文别名

——

英文名称

N⁴-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine

英文别名

4-(3-chloro-4-fluorophenyl)amino-6-amino-7-methoxyquinazoline；N-(3-chloro-4-fluorophenyl)-7-methoxy-6-aminoquinazolin-4-amine；N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine；4-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine

CAS

179552-75-1

化学式

C₁₅H₁₂ClFN₄O

mdl

——

分子量

318.738

InChiKey

QRZFUQFQXCRJRR-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

487.3±45.0 °C(Predicted)
密度：

1.458±0.06 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

3.4
重原子数：

22
可旋转键数：

3
环数：

3.0
sp3杂化的碳原子比例：

0.07
拓扑面积：

73.1
氢给体数：

2
氢受体数：

6

安全信息

储存条件：

室温且干燥环境下使用。

SDS

SDS：94d38f4ac503c7f6806fce320d2b765c

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上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
N-(3-氯-4-氟苯基)-7-甲氧基-6-硝基喹唑啉-4-胺	N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine	179552-74-0	C₁₅H₁₀ClFN₄O₃	348.721
N-(3-氯-4-氟苯基)-7-氟-6-硝基-4-喹唑啉胺	N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine	162012-67-1	C₁₄H₇ClF₂N₄O₂	336.685
4-氯-7-甲氧基-6-硝基喹唑啉-4(3H)-酮	4-chloro-7-methoxy-6-nitroquinazoline	55496-69-0	C₉H₆ClN₃O₃	239.618

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	(E)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)but-2-enamide	1245555-80-9	C₁₉H₁₅BrClFN₄O₂	465.709
——	N1-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N5-hydroxyglutaramide	1012054-73-7	C₂₀H₁₉ClFN₅O₄	447.853
——	(E)-N-[4-(3-chloro-4-fluoro-anilino)-7-methoxy-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide	1245555-42-3	C₂₁H₂₁ClFN₅O₂	429.881
——	(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(cyclopropylamino)but-2-enamide	——	C₂₂H₂₁ClFN₅O₂	441.892
——	methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate	1012057-50-9	C₂₄H₂₆ClFN₄O₄	488.946
——	Methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)propanoate	1146957-64-3	C₂₀H₁₈ClFN₄O₄	432.839
——	(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(cyclopropyl(methyl)amino)but-2-enamide	——	C₂₃H₂₃ClFN₅O₂	455.919
达克替尼	Dacomitinib	1110813-31-4	C₂₄H₂₅ClFN₅O₂	469.946
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-(4-hydroxybenzylidene)hydrazine carboxamide	——	C₂₃H₁₈ClFN₆O₃	480.886
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-(4-cyanobenzylidene)hydrazine carboxamide	——	C₂₄H₁₇ClFN₇O₂	489.896
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-(4-methoxybenzylidene)hydrazine carboxamide	——	C₂₄H₂₀ClFN₆O₃	494.913
——	(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(dicyclopropylamino)but-2-enamide	——	C₂₅H₂₅ClFN₅O₂	481.957
——	(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(thiomorpholine-1-oxide-4-yl)but-2-enamide	——	C₂₃H₂₃ClFN₅O₃S	503.985
——	(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(3, 3-difluorocyclobutylamino)but-2-enamide	——	C₂₃H₂₁ClF₃N₅O₂	491.9
——	(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide	1414884-63-1	C₂₆H₂₇ClFN₅O₂	495.984
——	(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.5]nonan-2-yl]-2-butenamide	1414884-64-2	C₂₇H₂₉ClFN₅O₂	510.011
——	(R,E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-3-[1-methylpyrrolidin-2-yl]propenamide	——	C₂₃H₂₃ClFN₅O₂	455.919
——	(S,E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazoline-6-yl}-3-[1-methylpyrrolidin-2-yl]propenamide	——	C₂₃H₂₃ClFN₅O₂	455.919
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-(2,3-dichlorobenzylidene)hydrazine carboxamide	——	C₂₃H₁₆Cl₃FN₆O₂	533.776
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(2-oxa-8-azaspiro[4.5]decan-8-yl)-2-butenamide	——	C₂₇H₂₉ClFN₅O₃	526.01
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)but-2-enamide	——	C₂₅H₂₅ClFN₅O₃	497.957
——	(E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-3-(4-methylmorpholin-3-yl)2-propenamide	——	C₂₃H₂₃ClFN₅O₃	471.919
——	(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-5-oxopyrrolidine-2-carboxamide	——	C₂₀H₁₇ClFN₅O₃	429.838
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-(4-(diethylamino)-2-hydroxybenzylidene)hydrazine carboxamide	——	C₂₇H₂₇ClFN₇O₃	552.008
——	(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-oxooxazolidine-4-carboxamide	——	C₁₉H₁₅ClFN₅O₄	431.811
——	(R)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-oxooxazolidine-4-carboxamide	——	C₁₉H₁₅ClFN₅O₄	431.811
——	diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-1-fluoro-2-oxoethyl)phosphonate	1420407-01-7	C₂₁H₂₂ClF₂N₄O₅P	514.853
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-(2,3,4-trimethoxybenzylidene)hydrazine carboxamide	——	C₂₆H₂₄ClFN₆O₅	554.965
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(hexahydro-2H-benzo[b][1,4]oxazin-4(3H)-yl)but-2-enamide	——	C₂₇H₂₉ClFN₅O₃	526.01
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(hexahydro-2H-benzo[b][1,4]thiazin-4(3H)-yl)but-2-enamide	——	C₂₇H₂₉ClFN₅O₂S	542.077
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(tetrahydro-2H-furo[3,2-b]pyrrol-4(5H)-yl)but-2-enamide	——	C₂₅H₂₅ClFN₅O₃	497.957
——	(Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-fluoro-4-((4aR,7aS)-tetrahydro-2H-[1,4]dioxino[2,3-c]pyrrol-6(3H)-yl)but-2-enamide	——	C₂₅H₂₄ClF₂N₅O₄	531.946
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-fluoro-4-((4aR,7aS)-tetrahydro-2H-[1,4]dioxino[2,3-c]pyrrol-6(3H)-yl)but-2-enamide	——	C₂₅H₂₄ClF₂N₅O₄	531.946
——	(4S,5R)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-5-methyl-2-oxooxazolidine-4-carboxamide	——	C₂₀H₁₇ClFN₅O₄	445.837
——	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6-(2H)-yl)-2-butenamide	——	C₂₆H₂₈ClFN₆O₃	526.998