7-羟基-4'-异丙基异黄酮 | 385817-63-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 中文名称: 7-羟基-4'-异丙基异黄酮
• 英文名称: 7-hydroxy-4'-isopropylisoflavone
• 英文别名: 7-Hydroxy-3-(4-propan-2-ylphenyl)chromen-4-one
• CAS: 385817-63-0
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.323
• InChiKey: OOUWUNUNXOTUSX-UHFFFAOYSA-N

物化性质

• 沸点：
  458.2±45.0 °C(Predicted)
• 密度：
  1.230±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-羟基-4'-异丙基异黄酮 在 sodium hydride 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 27.0h， 生成 3-[4-(1-methylethyl)phenyl]-7-[4-(piperazin-1-yl)butoxy]-4H-1-benzopyran-4-one bis[hydrochloride]
  参考文献：
  名称：

  Novel Basic Isoflavones as Inhibitors of Bone Resorption

  摘要：

  A number of aminoalkoxy analogues of ipriflavone (=7-(1-methylethoxy)isoflavone) were prepared and examined for their capacity to inhibit bone resorption induced by bovine parathyroid hormone fragment 1 - 34. Good-to-high activities were found for 7-(aminoalkoxy)isoflavone. analogues. Their activity was influenced by a number of structural features, among which the length of the basic side chain, the basicity of the amino group, and the nature and position of substituents on the 3-phenyl ring. 4'-(Aminoalkoxy)ipriflavone derivatives were less active.

  DOI：

  10.1002/1522-2675(20010815)84:8<2417::aid-hlca2417>3.0.co;2-n
• 作为产物：
  描述：

  依普黄酮 在 硫酸 作用下， 反应 18.0h， 以32%的产率得到7-羟基异黄酮
  参考文献：
  名称：

  Stability and Chemical Reactivity of 7-Isopropoxyisoflavone (Ipriflavone)

  摘要：

  DOI：

  10.1002/1099-0690(200110)2001:20<3911::aid-ejoc3911>3.0.co;2-0

文献信息

• Stability and Chemical Reactivity of 7-Isopropoxyisoflavone (Ipriflavone)
  作者：Márton Varga、Sándor Bátori、Mária Kövári-Rádkai、Ildikó Prohászka-Német、Magdolna Vitányi-Morvai、Zsolt Böcskey、Sándor Bokotey、Kálmán Simon、István Hermecz

  DOI：10.1002/1099-0690(200110)2001:20<3911::aid-ejoc3911>3.0.co;2-0

  日期：2001.10
• Novel Basic Isoflavones as Inhibitors of Bone Resorption
  作者：Maurizio Delcanale、Gabriele Amari、Elisabetta Armani、Milco Lipreri、Maurizio Civelli、Elisabetta Galbiati、Massimo Giossi、Paola Lorenza Caruso、Patrizia Crivori、Pierre-Alain Carrupt、Bernard Testa

  DOI：10.1002/1522-2675(20010815)84:8<2417::aid-hlca2417>3.0.co;2-n

  日期：2001.8.15

  A number of aminoalkoxy analogues of ipriflavone (=7-(1-methylethoxy)isoflavone) were prepared and examined for their capacity to inhibit bone resorption induced by bovine parathyroid hormone fragment 1 - 34. Good-to-high activities were found for 7-(aminoalkoxy)isoflavone. analogues. Their activity was influenced by a number of structural features, among which the length of the basic side chain, the basicity of the amino group, and the nature and position of substituents on the 3-phenyl ring. 4'-(Aminoalkoxy)ipriflavone derivatives were less active.