葛根素芹菜苷 | 103654-50-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 中文名称: 葛根素芹菜苷
• 中文别名: 葛根素芹菜糖苷
• 英文名称: Mirificin
• 英文别名: 8-[(2S,3R,4R,5S,6R)-6-[[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]-7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one
• CAS: 103654-50-8
• 化学式: C₂₆H₂₈O₁₃
• 分子量: 548.5
• InChiKey: ZBXWGKPUSLRPHX-QOIVFALESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  216
• 氢给体数：
  8
• 氢受体数：
  13

安全信息

• WGK Germany：
  3

文献信息

• Transdermal delivery of pharmaceutical agents
  申请人：Russell-Jones J. Gregory

  公开号：US20070243132A1

  公开（公告）日：2007-10-18

  The present invention generally relates to a vehicle useful for delivering a pharmaceutically active compound including a genetic molecule or composition. More particularly, the present invention provides microemulsions for transdermal delivery of pharmaceutically active agents to a subject.

  本发明通常涉及一种用于传递包括遗传分子或组成的药物活性化合物的车辆。更具体地，本发明提供了微乳液，用于经皮途径向受体传递药物活性剂。
• Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity
  申请人：Auransa Inc.

  公开号：US10806716B2

  公开（公告）日：2020-10-20

  This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3′,4′,5′-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

  本公开提供了减少或消除心脏毒性，特别是由癌症治疗或其他疗法引起的心脏毒性的方法和药物组合物。在某些情况下，这些方法和组合物可以预防或减少蒽环类药物治疗引起的心脏毒性。本文提供的方法通常包括在施用抗癌药物或其他疗法的同时施用一种保护剂，如麦角黄素、三黄素、洋槐黄素、黄荆素、槲皮素、二氢洋槐黄素、山柰酚、7,3′,4′,5′-四羟基黄酮和麦角黄素。它们可以包括将保护剂与右雷佐生联合使用。本文提供的组合物包括一种保护剂与另一种保护剂或与一种癌症治疗药物（如蒽环类药物）的共同制剂。
• Method for treating alcohol intoxication and alcohol abuse
  申请人：——

  公开号：US20020022634A1

  公开（公告）日：2002-02-21

  Treatment for alcohol dependence or intoxication that involves administering a pharmaceutical composition containing an extract of the kudzu plant, Pueraria lobata.

  治疗酒精依赖或酒精中毒的方法，包括使用含有葛根提取物的药物组合物、 葛
• Extracts derived from Pueraria mirifica, Butea superba and/or Mucuna collettii and extraction thereof
  申请人：CHEIL JEDANG CORPORATION

  公开号：US20040105900A1

  公开（公告）日：2004-06-03

  The present invention relates to extracts derived from Pueraria mirifica, Butea superba and/or Mucuna colletti and extraction thereof, foods, beverages, pharmaceutical products and/or cosmetics containing the extracts as an active ingredient and manufacturing thereof. The extracts isolated from the said plants contain higher concentration of isoflavones. The products products produced from composition containing the extracts considerably increase a resilience an gloss of skin at its application in human body.

  本发明涉及从以下植物中提取的提取物 葛根、艳紫铆和/或 和/或 提取物 的提取物，以及含有这些提取物作为活性成分的食品、饮料、药品和/或化妆品及其制造。从上述植物中分离出来的提取物含有较高浓度的异黄酮。用含有这些提取物的成分制成的产品在人体使用时能显著提高皮肤的弹性和光泽度。
• EXTRACTS DERIVED FROM PUERARIA MIRIFICA, BUTEA SUPERBA AND/OR MUCUNA COLLETTII AND EXTRACTION THEREOF
  申请人：Cheil Jedang Corporation

  公开号：EP1242103A1

  公开（公告）日：2002-09-25