β-氯醛糖 | 16376-36-6

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: β-氯醛糖
• 中文别名: 1,2-O-[(1S)-2,2,2-三氯亚乙基]-ALPHA-D-呋喃葡萄糖；β-葡萄糖缩氯醛；Β-三氯乙醛化葡萄糖
• 英文名称: β-chloralose
• 英文别名: β-glucochloralose；beta-Chloralose；(1R)-1-[(2S,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol
• CAS: 16376-36-6
• 化学式: C₈H₁₁Cl₃O₆
• 分子量: 309.531
• InChiKey: OJYGBLRPYBAHRT-GVUNPQSCSA-N

物化性质

• 熔点：
  234-236 °C (dec.)(lit.)
• 沸点：
  504.4±45.0 °C(Predicted)
• 密度：
  1.773

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.4
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 危险等级：
  6.1(b)
• 危险品标志：
  Xn
• 安全说明：
  S36
• 危险类别码：
  R20/21/22
• WGK Germany：
  3
• 包装等级：
  III
• 危险类别：
  6.1(b)
• 危险品运输编号：
  UN 2811

反应信息

• 作为反应物：
  描述：

  β-氯醛糖 在 吡啶 、 sodium periodate 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 3-O-acetyl-(S)-1,2-O-trichloroethylidene-5,6,8-trideoxy-α-D-xylo-oct-5(E)-eno-1,4-furano-7-ulose
  参考文献：
  名称：

  1,2-O-三氯亚乙基缩醛基保护的3,5-二烯-1,4-呋喃糖衍生物。

  摘要：

  3,5-（E）-dieno-3,5,6,8-四脱氧-（S）-1,2-O-三氯亚乙基-α-D-甘油-octo-1,4-呋喃酮-7的制备从1,2-O-（S）-三氯亚乙基-α-D-葡萄糖基呋喃糖（β-氯醛糖）或1,2-O-（S）-三氯亚乙基-α-D-半乳糖呋喃糖（半乳糖氯醛）开始3,5-（E）-dieno-3,5,6-trideoxy-（S）-1,2-O-trichloroethylidene-alpha-D-glycerome-hepta-1,4-furano-uronate的制备描述了β-氯藻糖。内环双键的形成是通过使用DMF-碳酸氢钠消除3-乙酰氧基来实现的。当起始化合物为1,2-O-（R）-三氯亚乙基-α-D-葡萄糖呋喃糖（α-氯醛糖）（其中三氯甲基占据内位）时，这种消除不成功。

  DOI：

  10.1016/s0008-6215(03)00337-9
• 作为产物：
  描述：

  O3,O5,O6-triacetyl-O1,O2-((S)-2,2,2-trichloro-ethylidene)-α-D-glucofuranose 在 甲醇 、 sodium methylate 作用下， 生成 β-氯醛糖
  参考文献：
  名称：

  Glucofuranose derivatives as a library for designing and investigating low molecular mass organogelators

  摘要：

  We designed and synthesized a class of saccharide-based gelators having three free OH groups in the glucofuranose fragment. The gelating abilities of fourteen compounds were examined to systematically study the influence of the hydrophobic fragment connected to the C2' carbon. Also the correlation between the saccharide crystal structure and its gelating properties was examined, showing limited usefulness in this particular case. SEM observations were carried out in order to investigate the hierarchical structure of xerogels and changes depending on different gel concentration. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.07.093

文献信息

• (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD

  公开号：US20180118658A1

  公开（公告）日：2018-05-03

  The present invention provides a (meth)acrylate manufacturing method characterized in that when manufacturing a (meth) acrylate by an ester exchange reaction between an alcohol and a monofunctional (meth)acrylate using catalyst A and catalyst B together, contact treatment of the ester exchange reaction product with adsorbent C is performed. Catalyst A: One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure and salts or complexes thereof, amidine and salts or complexes thereof, compounds with a pyridine ring and salts or complexes thereof, phosphines and salts or complexes thereof, and compounds with a tertiary diamine structure and salts or complexes thereof. Catalyst B: One or more kinds of compounds selected from a group consisting of compounds comprising zinc. Adsorbent C: One or more kinds of compounds selected from a group consisting of oxides and hydroxides comprising at least one of magnesium, aluminum and silicon.

  本发明提供了一种（甲基）丙烯酸酯制备方法，其特征在于通过在使用催化剂A和催化剂B一起进行醇和单官能基（甲基）丙烯酸酯之间的酯交换反应制备（甲基）丙烯酸酯时，对酯交换反应产物进行与吸附剂C的接触处理。催化剂A：从含有氮杂双环结构的环状三级胺及其盐或络合物、胺嘧啶及其盐或络合物、含有吡啶环的化合物及其盐或络合物、膦及其盐或络合物、以及含有三级二胺结构的化合物及其盐或络合物中选择的一种或多种化合物。催化剂B：从含锌化合物中选择的一种或多种化合物。吸附剂C：从含有镁、铝和硅中至少一种的氧化物和氢氧化物中选择的一种或多种化合物。
• MULTIFUNCTIONAL (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD.

  公开号：US20170204044A1

  公开（公告）日：2017-07-20

  [Problem] The purpose of the present invention is to obtain a multifunctional (meth)acrylate with good yield by an ester exchange reaction of a polyhydric alcohol such as pentaerythritol or dipentaerythritol with a monofunctional (meth)acrylate. [Solution] A multifunctional (meth)acrylate manufacturing method characterized in that when manufacturing a multifunctional (meth)acrylate by an ester exchange reaction of a polyhydric alcohol with a monofunctional (meth)acrylate, catalyst (A) and catalyst (B) are used together. Catalyst (A): One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure or salts or complexes thereof, amidines or salts or complexes thereof, and compounds with a pyridine ring or salts or complexes thereof. Catalyst (B): One or more kinds of compounds selected from a group consisting of zinc-containing compounds.

  [问题] 本发明的目的是通过多元醇（如戊三醇或二戊三醇）与单官能基（甲基）丙烯酸酯的酯交换反应，获得产率高的多功能（甲基）丙烯酸酯。[解决方案] 一种多功能（甲基）丙烯酸酯制备方法，其特征在于，在通过多元醇与单官能基（甲基）丙烯酸酯的酯交换反应制备多功能（甲基）丙烯酸酯时，同时使用催化剂（A）和催化剂（B）。催化剂（A）：选自具有氮杂双环结构的环三胺或其盐或络合物、酰胺或其盐或络合物以及吡啶环或其盐或络合物组成的群中的一种或多种化合物。催化剂（B）：选自含锌化合物组成的群中的一种或多种化合物。
• METHOD FOR PRODUCING (METH)ACRYLATE
  申请人：TOAGOSEI CO., LTD.

  公开号：US20180105483A1

  公开（公告）日：2018-04-19

  A method for producing a (meth) acrylate comprises transesterification reaction of an alcohol and a monofunctional (meth) acrylate with catalysts in combination being cyclic tertiary amines having an azabicyclo structure and compounds containing zinc, separating a solid that contains the catalysts from a reaction product containing a (meth) acrylate, and producing a (meth) acrylate by transesterification reaction of an alcohol and a monofunctional (meth) acrylate, while using the recovered solid catalyst.

  生产（甲基）丙烯酸酯的方法包括使用具有氮杂双环结构的环状三级胺和含锌化合物作为催化剂，将醇和单官能团（甲基）丙烯酸酯进行酯交换反应，从含有催化剂的固体中分离出含有（甲基）丙烯酸酯的反应产物，然后通过将醇和单官能团（甲基）丙烯酸酯进行酯交换反应，并使用回收的固体催化剂来生产（甲基）丙烯酸酯。
• The Knoevenagel-Doebner Reaction on 1,2-O-(2,2,2-Trichloroethylidene) Derivatives of D-Gluco- and D-Manno- furanose
  作者：Gökhan Kök、Tamer Karayıldırım、Kadir Ay、Emriye Ay

  DOI：10.3390/molecules15117724

  日期：——

  furanuronic acid derivatives of α-gluco- (3), β-gluco- (6) and β-manno-chloraloses (9) via a convenient one pot procedure using the Knoevenagel-Doebner reaction approach are described. The dialdofuranose derivatives were reacted with malonic acid under Knoevenagel-Doebner reaction conditions and (E)-α,β-unsaturated furanuronic acid derivatives were obtained.

  使用 Knoevenagel-Doebner 反应方法通过方便的一锅法合成新的 α-葡萄糖- (3)、β-葡萄糖- (6) 和 β-甘露糖-氯醛糖 (9) 的 α,β-不饱和呋喃糖醛酸衍生物被描述。二呋喃糖衍生物在Knoevenagel-Doebner反应条件下与丙二酸反应，得到(E)-α,β-不饱和呋喃糖醛酸衍生物。
• Herbicidal composition containing dioxolane, dioxane, or dioxepane
  申请人：Magyar Tudomanvos Akademia Kozponti Kemiai Kutato Intezete Nitrokemia

  公开号：US05116402A1

  公开（公告）日：1992-05-26

  The invention relates to a herbicidal composition which contains, besides binding, wetting, dispersing, emulsifying agents, solvents and/or surface-active substances, herbicides as active agent of thiocarbamate, carbamate, acid amide or urea type alone or in a combination, furthermore as antidote a compound of the general formula I ##STR1## wherein R.sup.1 and R.sup.2, independently of each other, are hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-4 cyanoalkyl, C.sub.1-6 haloalkyl, phenyl-C.sub.1-4 -haloalkyl, phenyl, halogenphenyl, C.sub.1-4 -alkyl-phenyl, C.sub.1-4 -alkoxyphenyl, furfuryl; R.sup.3 and R.sup.4, independently of each other, are hydrogen, C.sub.1-18 -alkyl, C.sub.2-4 -haloalkyl, C.sub.2-4 -cyanoalkyl, C.sub.1-4 -alkoxy-C.sub.2-4 -alkyl, C.sub.5-6 -cycloalkyl, phenyl-C.sub.1-4 -alkyl, C.sub.3-4 -alkenyl, phenyl-C.sub.3-4 -alkenyl, di-C.sub.1-4 -alkylamino-C.sub.2-4 -alkyl, hydroxy-C.sub.2-6 -alkyl, furfuryl, tetrahydrofurfuryl, C.sub.1-4 -alkoxy-C.sub.2-4 -alkoxy-C.sub.2-4 -alkyl; R.sup.3 and R.sup.4, together, are C.sub.2-4 -alkylene, C.sub.4 -alkenylene, glucofuranosylene, acetoxy-C.sub.3 -alkylene, C.sub.1-4 -alkoxy-C.sub.3 -alkylene, hydroxy-C.sub.3 -alkylene, halogen-C.sub.3 -alkylene; wherein the quantity of the antidote lies between 0.01 and 15 parts by weight referred to 1 part by weight of herbicidal agent, furthermore the composition contains altogether 0.1 to 95 percent by weight of the herbicidal agents and the antidote.

  本发明涉及一种除草剂组合物，除含有粘合剂、润湿剂、分散剂、乳化剂、溶剂和/或表面活性物质外，还含有硫代氨基甲酸酯、氨基甲酸酯、酸酰胺或脲类除草剂作为活性剂，单独或组合使用，此外还含有一种通式I的抗毒剂： ##STR1## 其中，R1和R2独立地为氢、C1-6烷基、C2-6烯基、C1-4氰基烷基、C1-6卤代烷基、苯基-C1-4-卤代烷基、苯基、卤代苯基、C1-4-烷基-苯基、C1-4-烷氧基苯基、呋喃基；R3和R4独立地为氢、C1-18烷基、C2-4卤代烷基、C2-4氰基烷基、C1-4-烷氧-C2-4-烷基、C5-6环烷基、苯基-C1-4-烷基、C3-4-烯基、苯基-C3-4-烯基、二-C1-4-烷基氨基-C2-4-烷基、羟基-C2-6-烷基、呋喃基、四氢呋喃基、C1-4-烷氧-C2-4-烷氧-C2-4-烷基；R3和R4在一起为C2-4-烷基、C4-烯基、葡萄糖呋喃糖基、乙酰氧-C3-烷基、C1-4-烷氧-C3-烷基、羟基-C3-烷基、卤代-C3-烷基；其中抗毒剂的数量在除草剂的1份重量中为0.01至15份重量，此外，该组合物总含量为0.1至95重量百分比的除草剂和抗毒剂。

表征谱图