2-苯基-1-丙胺盐酸盐 | 20388-87-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苯基-1-丙胺盐酸盐
• 中文别名: Beta-甲基苯乙胺盐酸盐
• 英文名称: 2-phenyl-1-propylamine hydrochloride
• 英文别名: hydron;2-phenylpropan-1-amine;chloride
• CAS: 20388-87-8
• 化学式: C₉H₁₃N*ClH
• mdl: MFCD01708026
• 分子量: 171.67
• InChiKey: HBVYOCJBEXSCQE-UHFFFAOYSA-N

物化性质

• 熔点：
  143-144℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.75
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090
• 储存条件：
  室温且干燥环境中使用。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
2-Phenylpropan-1-amine hydrochloride
Product Name:
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405: Store locked up

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Section 3. Composition/information on ingredients.
2-Phenylpropan-1-amine hydrochloride
Ingredient name:
CAS number: 20388-87-8

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Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C9H13N.ClH
Molecular weight: 171.7

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-苯基-1-丙胺盐酸盐 在 iron(III) chloride hexahydrate 、 硫酸 、 硝酸 、 甲烷 、 一水合肼 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 33.5h， 生成 N-[2-(4-aminophenyl)propyl]acetamide
  参考文献：
  名称：

  喹唑啉衍生物及其制备方法和应用

  摘要：

  本发明涉及喹唑啉衍生物及其制备方法和应用。该喹唑啉衍生物具有结构式，该喹唑啉衍生物以吉非替尼为阳性对照，结果表明与吉非替尼相比具有良好的活性；与先导化合物OTS514相比，活性相当，为PBK/TOPK抑制剂的进一步改造并发现新的抗肿瘤药物候选物具有较高的借鉴与参考价值。本发明还提出了上述喹唑啉衍生物的制备方法以及在制备PBK/TOPK抑制剂和抗癌药物中的应用。

  公开号：

  CN109942499B
• 作为产物：
  描述：

  α-甲基苯腈 在 5%-palladium/activated carbon 盐酸 、 氢气 作用下， 以 乙醇 、 水 为溶剂， 50.0~64.0 ℃ 、537.8 kPa 条件下， 反应 3.0h， 以76.2%的产率得到2-苯基-1-丙胺盐酸盐
  参考文献：
  名称：

  Sulfonamide derivatives

  摘要：

  本发明涉及一种式(Ia)的化合物或其药用可接受的盐，用于治疗与谷氨酸功能不足相关的疾病，如精神疾病和神经系统疾病。

  公开号：

  US20030233015A1
• 作为试剂：
  描述：

  水 、 α-甲基苯腈 、 盐酸 、 氢气 在 氮气 、 甲基叔丁基醚 、 2-苯基-1-丙胺盐酸盐 作用下， 以 乙醇 为溶剂， 反应 35.0h， 以to afford the intermediate title compound, 2-phenyl-1-propylamine HCl, (634.4 g, 76.2%) as a white powder的产率得到2-苯基-1-丙胺盐酸盐
  参考文献：
  名称：

  Heterocyclic sulfonamide derivatives

  摘要：

  本发明提供了一些公式(I)的杂环磺酰胺衍生物，用于增强患者的谷氨酸受体功能，因此，对于治疗各种疾病（如精神和神经系统障碍）非常有用。

  公开号：

  US20030225127A1

文献信息

• SUBSTITUTED 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONES AND USE THEREOF
  申请人：Brüggemeier Ulf

  公开号：US20100261771A1

  公开（公告）日：2010-10-14

  The present application relates to new, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新的、取代的2-乙酰胺基-5-芳基-1,2,4-三唑酮，以及制备它们的方法，它们单独或组合用于治疗和/或预防疾病，以及它们用于生产用于治疗和/或预防疾病的药物，更具体地用于治疗和/或预防心血管疾病。
• [EN] TRP-M8 RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS<br/>[FR] LIGANDS DU RÉCEPTEUR TRP-M8 ET LEUR UTILISATION DANS DES TRAITEMENTS
  申请人：AMGEN INC

  公开号：WO2009073203A1

  公开（公告）日：2009-06-11

  Tetrahydroisoquinoline compounds of formula (I), and compositions containing them, for the treatment of acute, inflammatory and neurophatic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neurophatic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintened pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  公式（I）的四氢异喹啉化合物及含有它们的组合物，用于治疗急性、炎症性和神经性疼痛、牙痛、普通头痛、偏头痛、集群头痛、混合血管和非血管综合征、紧张性头痛、一般炎症、关节炎、风湿性疾病、骨关节炎、炎症性肠道疾病、炎症性眼部疾病、炎症性或不稳定的膀胱疾病、牛皮癣、带有炎症成分的皮肤疾病、慢性炎症症状、炎症性疼痛及相关的过敏性疼痛和触痛、神经性疼痛及相关的过敏性疼痛和触痛、糖尿病性神经病痛、烧灼性疼痛、交感神经维持性疼痛、感觉缺失综合征、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸、泌尿、消化或血管区域内脏运动障碍、伤口、烧伤、过敏性皮肤反应、瘙痒、白癜风、一般胃肠道疾病、胃溃疡、十二指肠溃疡、腹泻、坏死性剂引起的胃病变、毛发生长、血管运动性或过敏性鼻炎、支气管疾病或膀胱疾病。
• Sulfonamide compounds
  申请人：Allison Brett

  公开号：US20060069286A1

  公开（公告）日：2006-03-30

  Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.

  某些磺酰胺化合物是双CCK1/CCK2抑制剂，在治疗CCK1/CCK2介导的疾病中很有用。
• Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
  申请人：Warner-Lambert Company

  公开号：US06300501B1

  公开（公告）日：2001-10-09

  Inhibitors of protein farnesyl transferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infections.

  蛋白质法尼基转移酶酶的抑制剂被描述，以及用于制备和药物组合物的方法，这些方法在治疗癌症、再狭窄、银屑病、子宫内膜异位症、动脉粥样硬化或病毒感染方面是有用的。
• Combination therapy for treatment of depression
  申请人：——

  公开号：US20030092770A1

  公开（公告）日：2003-05-15

  The present invention provides a method for treating depression, comprising administering to a patient an effective amount of a first component which is a suitable antidepressant, in combination with an effective amount of a second component which is a suitable AMPA receptor potentiator.

  本发明提供了一种治疗抑郁症的方法，包括向患者施用一种适量的第一成分，该成分是一种适当的抗抑郁药物，结合一种适量的第二成分，该成分是一种适当的AMPA受体增强剂。