磷酸吡哆醛 | 54-47-7

• 物质功能分类: 原料药 - 维生素类与矿物质类药 - 维生素B类药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 磷酸吡哆醛
• 中文别名: 3-羟基-2-甲基-5-[(膦酰氧基)甲基]-4-吡啶甲醛；辅去羧酶；PYRID氧杂L-5'-磷酸酯；3-羟基-2-甲基-5-[(磷酰氧基)甲基]-4-吡啶甲醛；磷酸-5'-吡哆醛；吡哆醛-5-磷酸；吡多醛-5-磷酸酯；3-羟基-2-甲基-5-磷酰氧甲基-4-吡啶甲醛；5-磷酸吡哆醛；吡多醛磷酸酯；磷酸吡哆醛(无水)；5-磷酸吡哆醛(无水)
• 英文名称: pyridoxal 5'-phosphate
• 英文别名: pyridoxal phosphate；PLP；pyridoxal 5’-phosphate；pyridoxal 5′-phosphate；pyridoxal 5’-phosphate monohydrate；(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
• CAS: 54-47-7
• 化学式: C₈H₁₀NO₆P
• mdl: MFCD00006333
• 分子量: 247.144
• InChiKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N

物化性质

• 熔点：
  140-143 °C
• 沸点：
  565.7±60.0 °C(Predicted)
• 密度：
  1.638±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（轻微加热）、甲醇（轻微）、水（轻微）
• LogP：
  -1.921 (est)
• 物理描述：
  Solid
• 碰撞截面：
  151.4 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  7

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  2936250000
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  本品应密封存放在4℃、干燥避光的环境中。

SDS

Name:	Pyridoxal 5-Phosphate 99% (Titr.) Material Safety Data Sheet
Synonym:	3-Hydroxy-2-Methyl-5-(Phosphonoxy)-4-Pyridinecarboxaldehyde; 1-Iodohexadecane
CAS:	54-47-7

Section 1 - Chemical Product MSDS Name:Pyridoxal 5-Phosphate 99% (Titr.) Material Safety Data Sheet
Synonym:3-Hydroxy-2-Methyl-5-(Phosphonoxy)-4-Pyridinecarboxaldehyde; 1-Iodohexadecane

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
54-47-7	4-Pyridinecarboxaldehyde,3-Hydroxy-2-M	99	200-208-3

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Light sensitive.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. Low hazard for usual industrial handling.
Inhalation:
May cause respiratory tract irritation. Low hazard for usual industrial handling.
Chronic:
None

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. No special precautions indicated. Store protected from light.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 54-47-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: light yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H10NO6P
Molecular Weight: 247.14

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide, oxides of potassium.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 54-47-7: UV1207000 LD50/LC50:
CAS# 54-47-7: Oral, mouse: LD50 = 4640 mg/kg; Oral, rat: LD50 = 5900 mg/kg.
Carcinogenicity:
4-Pyridinecarboxaldehyde,3-Hydroxy-2-Methyl-5-(Phosphonooxy) - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 54-47-7: 1
Canada
CAS# 54-47-7 is listed on Canada's DSL List.
CAS# 54-47-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 54-47-7 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

磷酸吡哆醛是一种有机化合物，分子式C8H10NO6P，由维生素B6与磷酸结合形成，包括吡哆醛、吡哆胺和吡哆醇。在体内以磷酸酯形式存在，并且其中的磷酸吡哆醛和磷酸吡哆胺可以互相转变，皆为活性型。磷酸吡哆醛是维生素B6的活性形式，在催化多种反应中起到重要作用。

生化作用—辅酶

磷酸吡哆醛广泛参与转氨基作用、α-脱羧作用、β-脱羧作用、β-消除作用、γ-消除作用、消旋作用及羟醛反应等。在所有转氨基作用以及某些氨基酸的脱羧与脱氨反应中，它作为辅酶发挥作用。

磷酸吡哆醛通过其醛基与特定赖氨酸基团形成希夫碱键（内部醛亚胺），参与催化反应。例如，在丝氨酸脱水酶和GDP-4-酮-6-脱氧甘露糖-3-脱水酶（ColD）的反应中，磷酸吡哆醛与谷氨酸起反应，生成磷酸吡哆胺（PMP）。随后，磷酸吡哆胺转移氮到特定底物上，形成氨基糖。

除此之外，磷酸吡哆醛还在血红素合成中的缩合反应、多巴转化为多巴胺以及兴奋性递质谷氨酸转化为抑制性递质γ-氨基丁酸等过程中发挥作用。在赖氨酸分解代谢中，它不参与转氨反应。

生理功能

作为维生素B6的辅酶形式，磷酸吡哆醛在催化反应中发挥关键作用。例如，在氨基酸代谢中的转氨、脱羧或消旋化过程中，磷酸吡哆醛分子内的醛基与α-氨基酸氨基结合形成希夫碱，再通过不同酶蛋白的作用使氨基酸发生相应变化。

应用

磷酸吡哆醛不仅是氨基酸代谢中转氨酶及脱羧酶的辅酶，还能促进谷氨酸脱羧生成γ-氨基丁酸。在临床治疗方面，它被用于提高体内多巴胺含量以缓解帕金森综合症症状等。

化学性质

白色结晶性粉末，无气味，在碱性溶液中呈亮黄色。水溶液需避光低温保存，见光会分解。易溶于甲酸、含水吡啶和稀碱液；微溶于水、乙醇、丙酮、氯仿及乙醚等有机溶剂。

用途

磷酸吡哆醛用于生化研究、孕甾酮特性的结构修饰以及作为酶抑制剂。此外，它还是维生素B6的主要药物之一，适用于治疗急慢性湿疹、皮肤炎等多种皮肤病症状，并且被认为是无毒的。

生产方法

以吡哆醇为原料制备磷酸吡哆醛。具体步骤是将吡哆胺二盐酸盐与无水磷酸反应成吡哆胺磷酸酯，然后通过二氧化锰氧化得到目标产物。