顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 | 15746-57-3

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物
• 中文别名: 顺-双(2,2'-二吡啶基)二氯化钌(II),二水；顺-双(2,2'-二吡啶基)二氯化钌(II),二水合物；顺-双(2；顺式-二氯二(2,2'-二吡啶)合钌(II)二水合物；顺-双(2,2-二吡啶基)二氯化钌(II)二水合物；顺式-二氯双(2,2'-联吡啶)钌二水合物
• 英文名称: Ru(bpy)₂Cl₂
• 英文别名: Ru(2,2-bipyridine)2Cl2；cis-Ru(bpy)₂Cl₂；Ru(2,2′-bipyridine)₂Cl₂；RuCl₂(bpy)₂；Ru(2,2’-bipyridine)₂Cl₂；Ru(bipyridine)₂Cl₂；[RuCl₂(bipy)₂]；Ru(bipy)₂Cl₂；(bpy)₂RuCl₂；cis-[Ru(2,2-bipyridine)₂Cl₂]；dichlorobis(2,2′-bipyridine)ruthenium(II)；cis-[Ru(bipy)₂Cl₂]；dichlorobis(bipyridine)ruthenium(II)；Ru(bpy)3Cl2；2-pyridin-2-ylpyridine;ruthenium(2+);dichloride
• CAS: 15746-57-3
• 化学式: C₂₀H₁₆Cl₂N₄Ru
• 分子量: 484.35
• InChiKey: MGAJEYXQYJBLQL-UHFFFAOYSA-L

物化性质

• 熔点：
  198-200℃
• 稳定性/保质期：
  在常温常压下稳定，应避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  5.66
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 安全说明：
  S24/25
• 储存条件：
  请将产品存放在常温环境下，密闭避光且保持通风和干燥。

SDS

Name:	cis-Dichlorobis(2 2 -bipyridine)ruthenium(II) dihydrate Material Safety Data Sheet
Synonym:	None Known
CAS:	15746-57-3

Section 1 - Chemical Product MSDS Name:cis-Dichlorobis(2 2 -bipyridine)ruthenium(II) dihydrate Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
15746-57-3	cis-Dichlorobis(2,2'-bipyridine)ruthen	ca. 100	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 15746-57-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystals
Color: black
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: C20H16Cl2N4Ru.2H2O
Molecular Weight: 520.38

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not currently available.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 15746-57-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
cis-Dichlorobis(2,2'-bipyridine)ruthenium(II) dihydrate - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 15746-57-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 15746-57-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 15746-57-3 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 以 乙二醇 、 乙腈 为溶剂， 生成 bis(acetonitrile)bis(2,2'-bipyridine)ruthenium(II)
  参考文献：
  名称：

  Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

  摘要：

  Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.

  DOI：

  10.1021/ja3009677
• 作为产物：
  描述：

  三(2,2'-联吡啶)钌II 在 盐酸 作用下， 以 二氯甲烷 为溶剂， 生成 顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物
  参考文献：
  名称：

  Barigelletti, Francesco; De Cola, Luisa; Balzani, Vincenzo, Inorganic Chemistry, 1989, vol. 28, # 24, p. 4344 - 4350

  摘要：

  DOI：
• 作为试剂：
  描述：

  茴香烯 在 Oxone 、 顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 、 四溴化碳 、 碳酸氢钠 作用下， 以 水 、 丙酮 、 乙腈 为溶剂， 反应 13.0h， 生成 1-bromo-1-(4-methoxyphenyl)propan-2-one
  参考文献：
  名称：

  可见光介导的富电子环氧化物的氧化猝灭反应：α-溴（二）酮的高度区域选择性合成及其机理研究†

  摘要：

  开发了一种新颖且简单的方法，用于通过可见光光氧化还原催化从富含电子的环氧化物中区域选择性合成α-溴（di）酮。通过优化溶剂和光源，可以在温和的条件下快速完成反应。此外，提出了可能的反应机理，并得到了对照实验的进一步支持。

  DOI：

  10.1039/c3ob41245h

文献信息

• Microwave synthesis of mixed ligand diimine–thiosemicarbazone complexes of ruthenium(ii): biophysical reactivity and cytotoxicity
  作者：Floyd A. Beckford、Michael Shaloski, Jr.、Gabriel Leblanc、Jeffrey Thessing、Lesley C. Lewis-Alleyne、Alvin A. Holder、Liya Li、Navindra P. Seeram

  DOI：10.1039/b915081a

  日期：——

  are best formulated as [(phen)(2)Ru(thiosemicarbazone)](PF(6))(2) and [(phen)(2)Ru(thiosemicarbazone)](PF(6))(2) where thiosemicarbazone = 9-anthraldehydethiosemicarbazone, 9-anthraldehyde-N(4)-methylthiosemicarbazone, and 9-anthraldehyde-N(4)-ethylthiosemicarbazone. Fluorescence competition studies with ethidium bromide, along with viscometric measurements suggests that the complexes bind calf thymus

  一种新型的微波辅助合成方法已被用于合成一系列含有二亚胺和双齿缩氨基硫脲配体的混合配体钌 (II) 化合物。该化合物含有二亚胺 1,10-菲咯啉 (phen) 或 2,2'-联吡啶 (bpy)，而缩氨基硫脲衍生自 9-蒽醛。根据元素分析和光谱数据，这些化合物最好配制成 [(phen)(2)Ru(缩氨基硫脲)](PF(6))(2) 和 [(phen)(2)Ru(缩氨基硫脲)](PF (6))(2) 其中缩氨基硫腙= 9-蒽醛缩氨基硫脲、9-蒽醛-N(4)-甲基缩氨基硫脲和9-蒽醛-N(4)-乙缩氨基硫脲。与溴化乙锭的荧光竞争研究，与粘度测量一起表明，复合物通过可能涉及二亚胺配体的芳环的嵌入模式相对强烈地结合小牛胸腺 DNA (CTDNA)。该复合物对 MCF-7 和 MDA-MB-231（乳腺腺癌）以及 HCT 116 和 HT-29（结肠直肠癌）细胞系显示出良好的细胞毒性特征。
• Facile synthesis of size dependent Ru(ii)–carbohydrate dendrimers via click chemistry
  作者：Raghavendra Kikkeri、Xinyu Liu、Alexander Adibekian、Yu-Hsuan Tsai、Peter H. Seeberger

  DOI：10.1039/b925113h

  日期：——

  A facile and flexible approach for the preparation of Ru(II) complexes containing different carbohydrates based on the Cu(II)-catalyzed Huisgen-[3+2] cycloaddition is described.

  描述了一种基于Cu（II）催化的Huisgen- [3 + 2]环加成反应制备包含不同碳水化合物的Ru（II）配合物的简便灵活的方法。
• Ultrafast Energy Transfer in Dinuclear Complexes with Bridging 1,10-Phenanthroline-5,6-Dithiolate
  作者：Elisa Erdmann、Matthias Lütgens、Stefan Lochbrunner、Wolfram W. Seidel

  DOI：10.1021/acs.inorgchem.7b02840

  日期：2018.5.7

  femtosecond (fs)-resolution}. All measurements supported by DFT calculations show that the observed effective luminescence quenching by the dithiolate coordinated metal is caused by an ultrafast singlet–singlet Dexter energy transfer.

  我们在本文中报道了在二亚胺部分和Ni（dppe ）上带有Ru（bpy）2或Ir（ppy）2的桥联配体1,10-菲咯啉-5,6-二硫盐（phendt 2-）的双核配合物的制备和表征），Ni（dppf），CoCp，RhCp *和Ru（p -Me- i在二硫醇酯单元上的Pr-苯）。与合成中使用的单核前体相比，所有双核配合物的特征均在于吸收和光致发光光谱以及循环伏安法。由于Ir / Co配合物对于光驱动电荷分离具有有益的光谱和电化学性质，因此通过时间分辨发光nanosecond（ns）-resolution}和瞬态吸收光谱法（femtosecond（fs））对这种配合物进行了详细研究。 -解析度}。DFT计算支持的所有测量结果表明，观察到的由二硫醇盐配位的金属进行的有效发光猝灭是由超快速单重态-单重Dexter能量转移引起的。
• [EN] PHOTOACTIVATED MOLECULES FOR LIGHT-INDUCED MODULATION OF THE ACTIVITY OF ELECTRICALLY EXCITABLE CELLS AND METHODS OF USING SAME<br/>[FR] MOLÉCULES PHOTO-ACTIVÉES POUR PHOTO-MODULATION DE L'ACTIVITÉ DE CELLULES ÉLECTRIQUEMENT EXCITABLES ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2014100283A1

  公开（公告）日：2014-06-26

  Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A "patch" or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

  方法和配方调节电兴奋细胞的活动。光电池化合物，在受到光能照射时，增加或减少细胞电活动。这些补充和/或替代基于将光能转化为视觉系统内某些细胞的电能的视觉。一种“贴片”或桥梁，用以绕过视觉系统中的一个或多个缺陷、损坏或病变细胞。此外，在多种实施方式中，正常视力的受试者也可以从本公开的方法、配方、系统或设备中受益，因为正常视力可以增强。照射引发能量（例如，接收光能，转化为电能，并传递该电能）从光电池化合物到细胞，从而改变细胞的跨膜电位和/或打开一个或多个离子通道，从而调节电兴奋细胞的活动。
• Investigation of a new bis(carboxylate)triazole-based anchoring ligand for dye solar cell chromophore complexes
  作者：Alessandro Sinopoli、Fiona A. Black、Christopher J. Wood、Elizabeth A. Gibson、Paul I. P. Elliott

  DOI：10.1039/c6dt02905a

  日期：——

  A novel anchoring ligand for dye-sensitised solar cell chromophoric complexes, 1-(2,2′-bipyrid-4-yl)-1,2,3-triazole-4,5-dicarboxylic acid (dctzbpy), is described. The new dye complexes [Ru(bpy)2(dctzbpy)][PF6]2 (AS16), [Ir(ppy)2(dctzbpy)][PF6] (AS17) and [Re(dctzbpy)(CO)3Cl] (AS18) were prepared in a two stage procedure with intermediate isolation of their diester analogues, AS16-Et2, AS17-Et2 and

  描述了一种新型的染料敏化太阳能电池发色配合物的锚定配体，即1-（2,2'-联吡啶-4-基）-1,2,3-三唑-4,5-二羧酸（dctzbpy）。新型染料配合物[Ru（bpy）2（dctzbpy）] [PF 6 ] 2（AS16），[Ir（ppy）2（dctzbpy）] [PF 6 ]（AS17）和[Re（dctzbpy）（CO）3 C1]（AS18）以两步程序制备，分别分离其二酯类似物AS16-Et 2，AS17-Et 2和AS18-Et 2。AS16-Et 2的电化学分析，AS17-Et 2和AS18-Et 2揭示了-1.50至-1.59 V（相对于Fc + / Fc）范围内的还原电位，相对于模型复合物[Ru（bpy）2（dcbH 2）] 2+（1）（E red＝ -1.34 V，dcbH 2＝ 2，2′-联吡啶-4，4′-二羧酸）。因此，这表明配合物的LUMO被正确地定位以在光激发时有利地电子转移到TiO