N-甲基-2-硝基苯胺 | 612-28-2

• 物质功能分类: 有机原料 - 氨基化合物 - 环烷胺、芳香单胺、芳香多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-甲基-2-硝基苯胺
• 中文别名: N-甲邻硝苯胺
• 英文名称: 2-nitro-N-methylaniline
• 英文别名: N-methyl-2-nitroaniline；N-methyl-o-nitroaniline；N-methyl-2-nitrobenzenamine；o-nitro-N-methylaminobenzene
• CAS: 612-28-2
• 化学式: C₇H₈N₂O₂
• mdl: MFCD00007090
• 分子量: 152.153
• InChiKey: KFBOUJZFFJDYTA-UHFFFAOYSA-N

物化性质

• 熔点：
  35-38 °C (lit.)
• 沸点：
  294.61°C (rough estimate)
• 密度：
  1.2333 (estimate)
• 闪点：
  >230 °F
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）
• LogP：
  0.972
• 稳定性/保质期：

  性质与稳定性：

  常温常压下，该物质不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• TSCA：
  Yes
• 危险等级：
  6.1
• 危险品标志：
  T
• 安全说明：
  S36/37,S45
• 危险类别码：
  R23/24/25,R33
• WGK Germany：
  3
• RTECS号：
  BY5710000
• 包装等级：
  II
• 危险类别：
  6.1
• 危险品运输编号：
  2811
• 危险性防范说明：
  P280,P301+P310
• 危险性描述：
  H301+H311+H331,H373
• 储存条件：
  贮存： 将密封的药瓶放置于阴凉、干燥处，保存在密封的主容器中。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: N-Methyl 2-nitroaniline
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H301: Toxic if swallowed
H311: Toxic in contact with skin
H331: Toxic if inhaled
H373: May cause damage to organs through prolonged or repeated exposure
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
P280: Wear protective gloves/protective clothing/eye protection/face protection
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P311: Call a POISON CENTER or doctor/physician

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Section 3. Composition/information on ingredients.
Ingredient name: N-Methyl 2-nitroaniline
CAS number: 612-28-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C7H8N2O2
Molecular weight: 152.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
UN Number: UN2811 Class: 6.1 Packing group: II
Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (N-Methyl 2-nitroaniline)

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N-甲基-2-硝基苯胺 在 N,N-二异丙基乙胺 、 三苯基膦 作用下， 以 癸烷 为溶剂， 反应 12.0h， 生成 1,2-二甲基苯并咪唑
  参考文献：
  名称：

  通过邻硝基硝基苯胺的膦介导的还原环化反应合成苯并咪唑

  摘要：

  加热邻硝基N-酰苯胺1 - 3和2-甲基- ñ - （3-硝基吡啶-2-基）丙酰胺（5）与4当量。的导致了2-取代的苯并咪唑的膦6 - 8和所述咪唑并[4,5- b ]吡啶10分别在45和85％之间的收率。用（EtO）3 P加热1会实现环化和N乙基化，从而生成1乙基苯并咪唑6b。N-新戊酰硝基苯胺2b的缓慢环化可分离出中间体膦亚胺11慢慢转化为1 H-苯并咪唑7b。的结构11，通过晶体结构分析确定。当N-甲基化的邻-硝基乙酰苯胺3环化成1,2-二甲基-1 H-苯并咪唑（8）时，2-甲基丙酰苯胺4被转化为1-甲基-3-（1-甲基乙基）-2 H-苯并咪唑‐2‐1（9）。

  DOI：

  10.1002/hlca.201100123
• 作为产物：
  描述：

  N-甲基-1,2-苯二胺 在 二过氧壬二酸 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以89%的产率得到N-甲基-2-硝基苯胺
  参考文献：
  名称：

  Steric-Hindrance-Induced Regio- and Chemoselective Oxidation of Aromatic Amines

  摘要：

  Unusual regio- and chemoselective oxidation of aromatic amines hindered with ortho substituents (except -NH2, -NHCH3, and -OH) to the corresponding nitro compounds is described by use of nonanebis(peroxoic acid). The mechanistic investigation for selective oxidation of amines ortho-substituted with -NH2 or -OH showed the involvement of H-bonding between the ortho hydrogen of the adjacent -XH group (where X = NH, NR, or O) and an oxygen atom from the diperoxy acid. Various mono- and diamines are oxidized into corresponding mononitro derivatives in high yield and purity without employing any protection strategies. The protocol was also found to successful on the gram scale.

  DOI：

  10.1021/acs.joc.5b00582

文献信息

• Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators
  申请人：Egle Ian

  公开号：US20090192169A1

  公开（公告）日：2009-07-30

  Compounds of Formula I: wherein A, B, D, L, R 1 , R 2 , R 3 , R 4 , m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

  式I的化合物： 其中A、B、D、L、R1、R2、R3、R4、m和n的定义如描述中所定义。本发明还涉及制备这些化合物的方法，以及用于制备的新中间体，含有这些化合物的药物组合物，以及这些化合物在治疗中的应用。
• Ru@PsIL-Catalyzed Synthesis of <i>N</i> -Formamides and Benzimidazole by using Carbon Dioxide and Dimethylamine Borane
  作者：Vitthal B. Saptal、Takehiko Sasaki、Bhalchandra M. Bhanage

  DOI：10.1002/cctc.201800185

  日期：2018.6.21

  This work reports the synthesis and characterization of ruthenium nanoparticles (Ru NPs) supported on polymeric ionic liquids (PILs). This catalyst shows high catalytic activity towards the N‐formylation of amines and synthesis of benzimidazoles from 1,2‐diamines and carbon dioxide (CO2) by reductive dehydrogenation of dimethylamine borane. This methodology shows excellent functional group tolerance

  这项工作报告了载于聚合物离子液体（PIL）上的钌纳米颗粒（Ru NPs）的合成和表征。该催化剂对胺的N-甲酰化和由1,2-二胺和二氧化碳（CO 2）通过二甲胺硼烷的还原脱氢合成苯并咪唑具有很高的催化活性。该方法显示出优异的官能团耐受性，在合成N-甲酰胺和苯并咪唑的过程中具有广泛的底物范围。有趣的是，该协议还提供了串联减少2-硝基胺和CO 2的方法。合成苯并咪唑 提出了聚合物的离子液相起关键作用，例如帮助静电稳定纳米颗粒，提供离子环境并控制底物/试剂易于接近活性位。开发的方法利用CO 2作为C 1源和水/乙醇作为绿色溶剂系统。另外，发现该催化剂本质上是可再循环的，并且显示出连续五次循环运行而其活性没有明显损失。
• Diversified facile synthesis of benzimidazoles, quinazolin-4(3H)-ones and 1,4-benzodiazepine-2,5-diones via palladium-catalyzed transfer hydrogenation/condensation cascade of nitro arenes under microwave irradiation
  作者：Kaicheng Zhu、Jian-Hong Hao、Cheng-Pan Zhang、Jiajun Zhang、Yiqing Feng、Hua-Li Qin

  DOI：10.1039/c4ra15765f

  日期：——

  An efficient methodology for diversified preparation of benzimidazole, quinazolin-4(3H)-ones and 1,4-benzodiazepine-2,5-diones is established using a Pd-CTH/condensation cascade of nitro arenes in a TEA–formic acid mixture under microwave irradiation.

  一种高效的方法学已建立，用于在微波辐射下利用Pd-CTH/缩合级联反应在TEA-甲酸混合物中多样化制备苯并咪唑、喹唑啉-4(3H)-酮和1,4-苯二氮杂环己酮。
• An easy one-step photocatalytic synthesis of 1-aryl-2-alkylbenzimidazoles by platinum loaded TiO2 nanoparticles under UV and solar light
  作者：K. Selvam、M. Swaminathan

  DOI：10.1016/j.tetlet.2011.04.090

  日期：2011.6

  One-pot synthesis of disubstituted benzimidazoles from N-substituted 2-nitroanilines or 1,2-diamines with 3–12 nm-sized platinum particles loaded on the TiO2 using solar and UV-A light is described. 1-Aryl-2-alkylbenzimidazoles from 2-nitrodiphenylamines are formed by combined redox photocatalytic reaction, condensation and catalytic dehydrogenation on Pt-TiO2. In case of diamines, this reaction is

  描述了使用太阳光和UV-A光由N-取代的2-硝基苯胺或1,2-二胺与负载在TiO 2上的3–12 nm大小的铂颗粒一锅合成二取代的苯并咪唑。通过在Pt-TiO 2上进行氧化还原光催化反应，缩合反应和催化脱氢反应，由2-硝基二苯胺形成1-芳基-2-烷基苯并咪唑类化合物。在二胺的情况下，该反应通过Pt-TiO 2辅助的醇的光催化氧化和铂纳米颗粒表面上的中间体的催化脱氢而进行。在这两种情况下，产物的形成都是通过在Pt-TiO 2上进行串联光催化和催化反应来实现的。