2-羟基-2-[(1-氧代-2-丙烯基)氨基]乙酸 | 6737-24-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-羟基-2-[(1-氧代-2-丙烯基)氨基]乙酸
• 中文别名: 乙酰胺甘醇酸；乙酰胺
• 英文名称: 2-acrylamidoglycolic acid
• 英文别名: hydroxy[(1-oxoallyl)amino]acetic acid；2-acrylamido-2-hydroxy-acetic acid；acrylamido glycolic acid；acrylamido-glycolic acid；acrylamidoglycolic acid；Acrylamido-N-glykolsaeure；Acetic acid, hydroxy[(1-oxo-2-propenyl)amino]-；2-hydroxy-2-(prop-2-enoylamino)acetic acid
• CAS: 6737-24-2
• 化学式: C₅H₇NO₄
• mdl: MFCD00010213
• 分子量: 145.115
• InChiKey: NEYTXADIGVEHQD-UHFFFAOYSA-N

物化性质

• 熔点：
  123-127 °C
• 沸点：
  264.2°C (rough estimate)
• 密度：
  0.82 g/mL at 20 °C
• 闪点：
  22 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 危险等级：
  8
• 危险品标志：
  Xn,Xi,C
• 安全说明：
  S16,S22,S24,S24/25,S26,S36,S36/37/39,S39,S45
• 危险类别码：
  R67,R36/37/38,R22,R10,R34,R41
• 海关编码：
  2924199090
• 包装等级：
  III
• 危险品运输编号：
  UN 1759

SDS

Name:	Acrylamido Glycolic Acid Anhydrous 98% Material Safety Data Sheet
Synonym:	2-Hydroxy-2-[(1-Oxo-2-Propenyl)amino]acetic Aci
CAS:	6737-24-2

Section 1 - Chemical Product MSDS Name:Acrylamido Glycolic Acid Anhydrous 98% Material Safety Data Sheet
Synonym:2-Hydroxy-2-[(1-Oxo-2-Propenyl)amino]acetic Aci

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
6737-24-2	Acrylamido Glycolic Acid	98	229-790-7

Hazard Symbols: C
Risk Phrases: 34

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.Light sensitive.Corrosive.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Causes skin burns.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns.
Inhalation:
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Use with adequate ventilation. Store protected from light. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Store protected from light.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 6737-24-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 125 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C5H7NO4
Molecular Weight: 145.11

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat, oxidizers.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 6737-24-2: AI2510000 LD50/LC50:
Not available.
Carcinogenicity:
Acrylamido Glycolic Acid - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE SOLID, N.O.S.*
Hazard Class: 8
UN Number: 1759
Packing Group: III
IMO
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing group: III

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 25 Avoid contact with eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 6737-24-2: No information available.
Canada
CAS# 6737-24-2 is listed on Canada's NDSL List.
CAS# 6737-24-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 6737-24-2 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  吩噻嗪 、 2-羟基-2-[(1-氧代-2-丙烯基)氨基]乙酸 在 硫酸 、 sodium carbonate 作用下， 以 乙醚 、 氯仿 为溶剂， 生成 甲基2-丙烯酰胺基-2-甲氧基乙酸酯
  参考文献：
  名称：

  Polyfunctional amine crosslinker, process for making same, and

  摘要：

  提供了一种无立体位阻的三官能原位胺。该化合物可用作含有胺反应性聚合物的交联剂。还提供了一种含有胺反应性聚合物和三官能原位胺的低温固化组合物，以及通过固化此类组合物获得的交联涂层。此外，还提供了一种合成新型三官能原位胺的方法。

  公开号：

  US04755623A1
• 作为产物：
  描述：

  丙烯酰胺 、 乙醛酸 在 4-甲氧基苯酚 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 3.0h， 以85.6 g的产率得到2-羟基-2-[(1-氧代-2-丙烯基)氨基]乙酸
  参考文献：
  名称：

  JP2015514071A5

  摘要：

  公开号：

  JP2015514071A5

文献信息

• Process for manufacturing N-acyl derivatives of hydroxy-arylglycines
  申请人：Nobel Hoechst Chimie

  公开号：US04105690A1

  公开（公告）日：1978-08-08

  Condensation of the addition product of glyoxylic acid and amides with hydroxyaryl compounds is effected by a first step, wherein the reaction is carried out hot, at a temperature below 60.degree. C, of an aliphatic amide having at the most 4 carbon atoms selected from the group of acetamide, chloracetamide, propionamide, acrylamide and butyramide, on an aqueous solution of glyoxylic acid. Then in a second step, after the addition of acetic acid and gaseous hydrochloric acid, condensation is effected at a temperature below 35.degree. C of the carboxamidoglycolic acid with an excess reaching 500% of hydroxyaryl compound selected from the group comprising phenol and its alkyl derivatives, their halogen derivatives, polyphenols and their ethers and betanaphthol. After the condensation of said second step, the volatile products are removed by vacuum distillation. When the hydroxyaryl compound is phenol, the crude product resulting from this distillation is taken up in nitromethane or water, which are a non-solvent of the N-acyl derivative of parahydroxyphenylglycine but a solvent of the corresponding ortho derivative; the proportion of the para derivative in the resulting compound is then of the order of 100%.

  甘氨酸和酰胺的加成产物与羟基芳基化合物的缩合作用是通过第一步实现的，其中反应在高温下进行，温度低于60摄氏度，在含有甘氨酸的水溶液中，作用于最多含有4个碳原子的脂肪酰胺，所述脂肪酰胺选自乙酰胺、氯乙酰胺、丙酰胺、丙烯酰胺和丁酰胺。然后，在第二步中，在加入乙酸和气态盐酸后，在温度低于35摄氏度下，将羧胺基甘氨酸与羟基芳基化合物缩合，所述缩合物中羟基芳基化合物的过量达到羟基芳基化合物的500%，所述羟基芳基化合物选自苯酚及其烷基衍生物、卤代衍生物、多酚及其醚和β-萘酚。在第二步的缩合后，通过真空蒸馏去除挥发性产物。当羟基芳基化合物为苯酚时，通过硝基甲烷或水将此蒸馏得到的粗产品溶解，硝基甲烷或水是对邻羟基苯甘氨酸的非溶剂但是对相应的邻位衍生物是溶剂；因此所得化合物中对位衍生物的比例约为100%。
• Ethers of acrylamidoglycolic acid and esters
  申请人：American Cyanamid Company

  公开号：US04656308A1

  公开（公告）日：1987-04-07

  Ethylenically unsaturated monomers containing activated ester groups are used to make polymers and copolymers which are useful in coatings, adhesives and moldings.

  含有活性酯基团的乙烯不饱和单体被用来制造在涂料、粘合剂和成型中有用的聚合物和共聚物。
• Bound textile sheet and procedure for its manufacture
  申请人：Rohm GmbH Chemische Fabrik

  公开号：US04689264A1

  公开（公告）日：1987-08-25

  A method for the manufacture of bound textile sheets, comprising treating a textile sheet substrate with a water dispersion of a mixed polymerizate binder of: (a) 80-99% by wt. of a C.sub.1-8 alkyl ester of acrylic acid, a C.sub.1-8 alkyl ester of methacrylic acid, or combination thereof, or a mixture of at least one of said acrylate or methacrylate esters with styrene, (b) 1-10% by wt. of an acrylamide glycolic acid monomer of the formula: ##STR1## wherein R is hydrogen or methyl, R' is alkyl and R" is hydrogen or alkyl, and (c) 0-20% by wt. of another comonomer.

  一种制造粘合纺织品片的方法，包括将纺织品片基材用混合聚合物粘合剂的水分散液处理，所述混合聚合物粘合剂包括：(a) 80-99%重量的丙烯酸C.sub.1-8烷基酯、甲基丙烯酸C.sub.1-8烷基酯或两者的组合物，或者至少其中一种丙烯酸酯或甲基丙烯酸酯与苯乙烯的混合物；(b) 1-10%重量的甘氨酸乙酰基丙烯酰胺单体，其化学式为：##STR1## 其中R为氢或甲基，R'为烷基，R"为氢或烷基；(c) 0-20%重量的另一种共聚单体。
• Activated ester monomers and polymers
  申请人：American Cyanamid Company

  公开号：US04778869A1

  公开（公告）日：1988-10-18

  Ethylenically unsaturated monomers containing activated ester groups are used to make polymers and copolymers which are useful in coatings, adhesives and moldings.

  含有活性酯基的乙烯不饱和单体被用于制造聚合物和共聚物，这些聚合物和共聚物在涂料、粘合剂和模塑方面非常有用。
• Schouteeten,A. et al., Bulletin de la Societe Chimique de France, 1978, vol. <II>, p. 248 - 254
  作者：Schouteeten,A. et al.

  DOI：——

  日期：——

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