[(己氧基)甲基]环氧乙烷 | 5926-90-9

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 环烃
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 中文名称: [(己氧基)甲基]环氧乙烷
• 英文名称: n-Hexyl-glycidylaether
• 英文别名: Hexyl glycidyl ether；2-(hexoxymethyl)oxirane
• CAS: 5926-90-9
• 化学式: C₉H₁₈O₂
• mdl: MFCD01697722
• 分子量: 158.241
• InChiKey: JPEGUDKOYOIOOP-UHFFFAOYSA-N

物化性质

• 沸点：
  223.34°C (rough estimate)
• 密度：
  0.9003 (rough estimate)
• 物理描述：
  Hexyl glycidyl ether is a clear colorless liquid. (NTP, 1992)
• 溶解度：
  less than 1 mg/mL at 73° F (NTP, 1992)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险类别码：
  R45,R46

反应信息

• 作为反应物：
  描述：

  [(己氧基)甲基]环氧乙烷 在 氯化亚砜 作用下， 以 水 、 苯 为溶剂， 生成 1-Diethylamino-2-chlor-3-hexyloxy-propan
  参考文献：
  名称：

  Mamedov,S. et al., Journal of Organic Chemistry USSR (English Translation), 1966, vol. 2, p. 1369 - 1372

  摘要：

  DOI：
• 作为产物：
  描述：

  5-己烯-1-醇 在 5percent Pd/C(en) sodium hydroxide 、 氢气 、 四丁基硫酸氢铵 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 [(己氧基)甲基]环氧乙烷
  参考文献：
  名称：

  Highly Chemoselective Hydrogenation with Retention of the Epoxide Function Using a Heterogeneous Pd/C-Ethylenediamine Catalyst and THF

  摘要：

  In general, palladium-carbon (Pd/C) catalyzed hydrogenation of epoxides affords the corresponding primary and secondary alcohols as a mixture. It has been found that the catalytic activity of a Pd/C -ethylenediamine complex catalyst [Pd/C(en)] in the hydrogenolysis of epoxide functions is drastically reduced. Herein we describe a mild and chemoselective method for the hydrogenation of olefin, nitro, and azide functions with retention of the epoxide function. The chemoselectivity was accomplished by using a combination of 5% Pd/C(en) and THF as solvent. A significant drop in the chemoselectivity of the hydrogenation is observed with 5% Pd/C(en) in MeOH. These results reinforce the utility of epoxides as important precursors of alcohols in synthetic chemistry.

  DOI：

  10.1002/1521-3765(20000616)6:12<2200::aid-chem2200>3.0.co;2-3

文献信息

• Silica-tethered cuprous acetophenone thiosemicarbazone (STCATSC) as a novel hybrid nano-catalyst for highly efficient synthesis of new 1,2,3-triazolyl-based metronidazole hybrid analogues having potent antigiardial activity
  作者：Mohammad Navid Soltani Rad、Somayeh Behrouz、Javad Mohammadtaghi-Nezhad、Elham Zarenezhad、Mahmoud Agholi

  DOI：10.1002/aoc.4799

  日期：2019.4

  varied promising antigiardial activity compare to metronidazole as a reference drug. Among the products, 1‐(4‐((2‐methyl‐5‐nitro‐1H‐imidazol‐1‐yl)methyl)‐1H‐1,2,3‐triazol‐1‐yl)‐3‐phenethoxypropan‐2‐ol and 1‐(4‐((2‐methyl‐5‐nitro‐1H‐imidazol‐1‐yl)methyl)‐1H‐1,2,3‐triazol‐1‐yl)‐3‐(3‐phenylpropoxy)propan‐2‐ol are demonstrated to exhibit the potent antigiardial activity even stronger than metronidazole.

  硅胶束缚的乙苯乙酮硫代氨基脲（STCATSC）作为新型杂化纳米催化剂的合成，表征和应用，用于合成新的1,2,3-三唑基甲硝唑杂化类似物。STCATSC具有多种不同的微观，光谱和物理技术，包括扫描电子显微镜（SEM），透射，X射线衍射（XRD），能量色散X射线光谱（EDS），热重分析（TGA），FT-红外和电感耦合等离子体（ICP）分析。该催化剂用于制备新的1,2,3-三唑基甲硝唑杂化类似物。2-甲基-5-硝基-1-丙-2-炔基-1 H的'点击'Huisgen环加成反应室温下，THF水介质中的具有各种β-叠氮基醇的咪唑为产品提供了良好的收率（使用STCATSC）。事实证明，STCATSC是一种稳定，低成本，可重复使用且对环境无害的混合催化剂。产品针对兰氏贾第鞭毛虫（G. lamblia）进行了体外测试，在该试验中，与甲硝唑作为参考药物相比，确定所有化合物均表现出不同的有希望的抗真菌活性。在这
• ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND BETA-DIKETONE COMPOUND
  申请人：Yamada Takashi

  公开号：US20100129753A1

  公开（公告）日：2010-05-27

  An alkali developable photosensitive resin composition contains (J) a photopolymerizable unsaturated compound having a structure resulting from the addition reaction of (B) a compound having a β-diketone moiety or a compound having a β-ketoester group to the (meth)acryloyl group of (A) a compound having at least two (meth)acryloyl groups and a hydroxyl group and subsequent esterification of the hydroxyl group of the resulting addition product with (C) a polybasic acid anhydride. The compound having a β-diketone moiety is preferably a novel β-diketone compound represented by general formula (I): wherein R 1 is a C1-C20 alkyl group; R 2 represents R 11 , OR 11 , COR 11 , SR 11 , CONR 12 R 13 , or CN; R 11 , R 12 , and R 13 are each hydrogen, a C1-C20 alkyl group, etc.; a is 0 to 3; and b is 0 to 4.

  一种可由碱显影的光敏树脂组合物，含有（J）一种光聚合不饱和化合物，该化合物的结构是由（B）含β-二酮基团或含β-酮酯基团的化合物与（A）含至少两个(甲基)丙烯酰基团和一个羟基的化合物中的(甲基)丙烯酰基团发生加成反应，并随后将所得加成产物的羟基与（C）多元酸酐进行酯化反应得到的。含β-二酮基团的化合物最好是表示为通用公式（I）的一种新型β-二酮化合物：其中R1是C1-C20烷基团；R2代表R11、OR11、COR11、SR11、CONR12R13或CN；R11、R12和R13分别是氢、C1-C20烷基团等；a是0到3；b是0到4。
• ORGANIC ELECTRONIC MATERIAL, POLYMERIZATION INITIATOR AND THERMAL POLYMERIZATION INITIATOR, INK COMPOSITION, ORGANIC THIN FILM AND PRODUCTION METHOD FOR SAME, ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, LIGHTING DEVICE, DISPLAY ELEMENT, AND DISPLAY DEVICE
  申请人：Ishitsuka Kenichi

  公开号：US20130037753A1

  公开（公告）日：2013-02-14

  Disclosed is an organic electronic material comprising charge transporting compounds and ionic compounds having electron-accepting properties and high solubility in a solvent. The organic electronic material is characterized by comprising charge transporting compounds and ionic compounds, and in that at least one of the ionic compounds is any one kind of compounds represented by general formulas (1b)-(3b). (In the formulas Y 1 -Y 6 each independently represent a divalent linking group, R 1 -R 6 each independently represent an electron-attracting organic substituent (these structures can further have substituents and hetero-atoms, and R 1 , R 2 and R 3 , or, R 4 -R 6 can respectively combine and become a ring shape or a polymer shape) and L + represents a monovalent cation.)

  本文揭示了一种有机电子材料，包括具有电荷传输化合物和具有接受电子性质且在溶剂中具有高溶解度的离子化合物。该有机电子材料的特点在于包括电荷传输化合物和离子化合物，并且至少其中一个离子化合物是由通用式（1b）-（3b）表示的化合物中的任意一种。（在式中，Y1-Y6分别表示二价连接基团，R1-R6分别表示吸引电子的有机取代基（这些结构可以进一步具有取代基和杂原子，且R1、R2和R3，或者R4-R6可以分别结合形成环状或聚合物形状），L+表示一价阳离子。）
• Method of using calcilytic compounds
  申请人：NPS Pharmaceuticals, Inc.

  公开号：US06022894A1

  公开（公告）日：2000-02-08

  The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.

  本发明涉及钙受体拮抗剂化合物。"钙受体拮抗剂化合物"指的是能够抑制钙受体活性的化合物。还描述了利用钙受体拮抗剂化合物来抑制钙受体活性和/或在患者中达到有益效果的方法；以及可用于获取额外钙受体拮抗剂化合物的技术。
• Thermal desulfurization of (alkoxymethyl)thiiranes
  作者：S. A. Nalet’ko、M. G. Pervova、T. I. Gorbunova、A. Ya. Zapevalov、M. S. Toporova、V. I. Saloutin

  DOI：10.1134/s1070363214110139

  日期：2014.11

  afforded the corresponding thiiranes, and catalyst-free thermal desulfurization of the products has been studied. The major products of desulfurization are alcohols and alkenes, both in the cases of (polyfluoroalkyloxymethyl)thiiranes and their non-fluorinated analogs. Longer alkyl chain in thiiranes favors formation of alcohols over alkenes formation in the course of desulfurization.

  （烷氧基甲基）氧杂环戊烷与硫脲在甲醇中的反应得到了相应的噻喃，并且已经研究了产物的无催化剂热脱硫。脱硫的主要产物是醇和烯烃，在（聚氟烷氧基甲基）硫杂环丁烷及其非氟化类似物的情况下。在脱硫过程中，硫烷中较长的烷基链比烯烃的形成更有利于醇的形成。