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三白脂素 A | 88497-87-4

中文名称
三白脂素 A
中文别名
三白脂素A
英文名称
manassantin A
英文别名
1-(3,4-Dimethoxyphenyl)-2-[4-[5-[4-[1-(3,4-dimethoxyphenyl)-1-hydroxypropan-2-yl]oxy-3-methoxyphenyl]-3,4-dimethyloxolan-2-yl]-2-methoxyphenoxy]propan-1-ol
三白脂素 A化学式
CAS
88497-87-4
化学式
C42H52O11
mdl
——
分子量
732.868
InChiKey
ZGXXNVOBEIRACL-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    82-85℃
  • 沸点:
    836.0±65.0 °C(Predicted)
  • 密度:
    1.172±0.06 g/cm3 (20 ºC 760 Torr)

计算性质

  • 辛醇/水分配系数(LogP):
    6.8
  • 重原子数:
    53
  • 可旋转键数:
    16
  • 环数:
    5.0
  • sp3杂化的碳原子比例:
    0.43
  • 拓扑面积:
    124
  • 氢给体数:
    2
  • 氢受体数:
    11

安全信息

  • WGK Germany:
    3

反应信息

点击查看最新优质反应信息

文献信息

  • [EN] MANASSANTIN COMPOUNDS AND METHODS OF MAKING AND USING SAME<br/>[FR] COMPOSÉS DE MANASSANTIN ET LEURS PROCÉDÉS DE PRODUCTION ET D'UTILISATION
    申请人:UNIV DUKE
    公开号:WO2010059858A1
    公开(公告)日:2010-05-27
    Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further provided are pharmaceutical compositions comprising compounds according to Formula I. Also provided are methods of inhibiting HIF-1 in a cell, the methods comprising administering to the cell a compound according to Formula I.
    提供了manassantin化合物和使用该化合物的方法。提供了治疗疾病的方法,该方法包括给予符合公式I的化合物。另外提供了包含符合公式I的化合物的药物组合物。还提供了在细胞中抑制HIF-1的方法,该方法包括给予细胞符合公式I的化合物。
  • SAURURUS CERNUUS COMPOUNDS THAT INHIBIT CELLULAR RESPONSES TO HYPOXIA
    申请人:Nagle Dale G.
    公开号:US20090137664A1
    公开(公告)日:2009-05-28
    Compounds and compositions that effectively block hypoxia-inducible factor-1 function, and methods of use thereof. The compounds and compositions of the present invention are useful in the prevention and treatment of cancer, stroke, heart disease, ocular neovascular diseases, and arthritis.
  • MANASSATIN COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    申请人:Hong Jiyong
    公开号:US20110230540A1
    公开(公告)日:2011-09-22
    Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further provided are pharmaceutical compositions comprising compounds according to Formula I. Also provided are methods of inhibiting HIF-1 in a cell, the methods comprising administering to the cell a compound according to Formula I.
  • US8946289B2
    申请人:——
    公开号:US8946289B2
    公开(公告)日:2015-02-03
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