1,1'-(1,2-乙二基)二[二苯基-氧膦] | 4141-50-8

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,1'-(1,2-乙二基)二[二苯基-氧膦]
• 英文名称: 1,2-bis(diphenylphosphinoyl)ethane
• 英文别名: ethane-1,2-diylbis(diphenylphosphine oxide)；1,2-bis(diphenylphosphino)ethane dioxide；2-(Diphenylphosphoryl)ethyl(diphenyl)phosphine oxide；[2-diphenylphosphorylethyl(phenyl)phosphoryl]benzene
• CAS: 4141-50-8
• 化学式: C₂₆H₂₄O₂P₂
• 分子量: 430.423
• InChiKey: YIMUMKVZUBHTPB-UHFFFAOYSA-N

物化性质

• 熔点：
  269-270 °C
• 沸点：
  553.7±33.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2902909090

反应信息

• 作为反应物：
  描述：

  1,1'-(1,2-乙二基)二[二苯基-氧膦] 在 三苯碳四(五氟苯基)硼酸盐 、 苯硅烷 作用下， 以 氘代甲苯 为溶剂， 反应 13.5h， 以97%的产率得到1,2-双(二苯基膦)乙烷
  参考文献：
  名称：

  三苯甲基阳离子介导的氧化膦还原

  摘要：

  描述了使用PhSiH 3作为还原剂和Ph 3 C + [B(C 6 F 5 ) 4 ] -作为引发剂将氧化膦还原成相应的膦。该方法效率很高，可以减少各种带有各种官能团的仲和叔烷基和芳基膦，收率通常很高。据信，该反应通过生成甲硅烷基阳离子进行，该阳离子与氧化膦反应提供鏻盐，进一步被硅烷还原以提供所需的膦和硅氧烷。

  DOI：

  10.1002/adsc.202100189
• 作为产物：
  描述：

  1,2-bis(diphenylphosphino)ethane bis(borane) 在 叔丁基过氧化氢 作用下， 以 丁酮 为溶剂， 以85%的产率得到1,1'-(1,2-乙二基)二[二苯基-氧膦]
  参考文献：
  名称：

  Chemo-, regio- and stereoselective conversion of P-chirogenic phosphorus borane complexes into their PO or PS derivatives

  摘要：

  Chiral and achiral organophosphorus borane complexes are readily transformed into their corresponding phosphoryl or thiophosphoryl compounds in high yields using one-pot procedures with stereoselectivities reaching 100% in many cases. Both oxidation and sulfuration were performed under neutral or mild conditions and were applied to various organophosphorus borane complexes (phosphines, phosphinates, chlorophosphines, aminophosphines, etc.). In the case of the dissymmetric diphosphine or aminophosphine phosphinite ligands, the reaction of their diborane complexes proceeds regiospecifically to a single phosphorus group, affording the corresponding hybrid derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00236-1
• 作为试剂：
  描述：

  十二烷二酸 在 氯化亚砜 、 1,1'-(1,2-乙二基)二[二苯基-氧膦] 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 4,6-(1,16-(2,15-diaza-3,14-dioxohexadecamethylene))-3,7-dimethyl-1,5-diazabicyclo<3.3.0>octa-3,6-diene-2,8-dione
  参考文献：
  名称：

  Bimane cyclic esters, possible stereologues of trypanothione as antitrypanosomal agents. Bimanes 29

  摘要：

  Tricyclic esters derived from bimanes have been synthesized with ring sizes near or equal to that of trypanothione disulfide (T(S)(2)), a bis-glutathionylspermidine that is involved in regulating the thiol status of Leishmania and other trypanosomatids. Modest activity for many of the compounds against Leishmania donovani with a maximum at the T(S)(2) ring size suggests that the esters act as T(S)(2) surrogates. However, no inhibition of T(S)(2)-reductase is observed for a number of the compounds. A series of tricyclic bimane amides with structures more closely analogous to T(S)2 are inactive in biological tests, New approaches were developed for the synthesis of the amides. The surprising effectiveness of the cyclic ester synthesis is explained. Acid chloride formation catalyzed by sulfides is briefly described.

  DOI：

  10.1016/0223-5234(96)88283-3

文献信息

• HYDROGENATION OF ESTERS OR CARBONYL GROUPS WITH PHOSPHINO-OXIDE BASED RUTHENIUM COMPLEXES
  申请人：Saudan Lionel

  公开号：US20110190523A1

  公开（公告）日：2011-08-04

  The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of specific ruthenium catalysts or pre-catalysts in hydrogenation processes for the reduction of ketones, aldehydes, esters or lactones into their corresponding alcohols or diols respectively. The preferred catalysts are ruthenium complexes comprising a ligand of the type (N—N) type and a ligand of the type (P—PO).

  本发明涉及催化加氢领域，更具体地涉及在加氢过程中使用特定的钌催化剂或前驱体，用于将酮、醛、酯或内酯还原为相应的醇或二醇。首选催化剂是包含(N—N)型配体和(P—PO)型配体的钌配合物。
• [EN] ARGINASE INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS D'ARGINASE ET PROCÉDÉS D'UTILISATION
  申请人：MERCK SHARP & DOHME

  公开号：WO2019177873A1

  公开（公告）日：2019-09-19

  Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.

  本文描述了化合物I的结构或其药用盐。化合物I作为精氨酸酶抑制剂，可用于预防、治疗或作为精氨酸酶相关疾病的治疗剂。
• Phosphine oxide complexes of thorium(IV), uranium(IV), neptunium(IV), and dioxouranium(VI) nitrates
  作者：Kenneth W. Bagnall、Malcolm W. Wakerley

  DOI：10.1039/dt9740000889

  日期：——

  Complexes of the actinoid tetranitrates with phosphine oxides, M(NO3)4,xR3PO (R = Me(tmpo), M = Th, U, X = 4 and M = Th, Np, x= 3; R = Prn(tprpo), M = Th, U, Np, x= 2·67; R = Bun(tbpo) M = Th, x= 4; R = Me2N(hmpa), M = Th, U, Np, x= 2; R = Ph(tppo), M = Np, x= 2) and with the bidentate phosphine oxides, octamethylpyrophosphoramide(ompa), Th(NO3)4,2·5ompa and M(NO3)4,1·5ompa (M = Th, U, Np), bis(diphenylphosphinyl)

  nit系四硝酸盐与氧化膦的复合物M（NO 3）4，x R 3 PO（R = Me（tmpo），M = Th，U，X = 4和M = Th，Np，x = 3; R = Pr n（tprpo），M = Th，U，Np，x = 2·67； R = Bu n（tbpo）M = Th，x = 4； R = Me 2 N（hmpa），M = Th，U， Np，x = 2； R = Ph（tppo），M = Np，x = 2）且带有二齿膦氧化物，八甲基吡咯磷酰胺（ompa），Th（NO 3）4，2 ·5ompa和M（NO 3）4制备了1,5ompa（M = Th，U，Np），双（二苯基膦基）甲烷（ppm），Th（NO 3）4 1·5ppm和双（二苯基膦基）乙烷，Th（NO 3）4 2ppe ，以及铀（VI）类似物UO 2（NO 3）2，x L（L = tprpo，x = 2； L = ppm，x = 1
• Isolable and Readily Handled Halophosphonium Pre-reagents for Hydro- and Deuteriohalogenation
  作者：Florian T. Schevenels、Minxing Shen、Scott A. Snyder

  DOI：10.1021/jacs.6b12653

  日期：2017.5.10

  and acid-sensitive moieties, particularly polyenes prone to cyclization. The process is also challenging when conducted on a small scale, and moreover, methods for the addition of their deuterated counterparts typically require special techniques, especially when control of stoichiometry is required. Herein is described a readily synthesized and handled reagent class which can accomplish the controlled

  尽管对跨烯烃添加酰卤进行了充分研究，但许多具有离去基团、多不饱和度和酸敏感部分的底物类别仍然存在局限性，特别是易于环化的多烯。该过程在小规模进行时也具有挑战性，此外，添加氘代对应物的方法通常需要特殊技术，尤其是在需要控制化学计量时。本文描述了一种易于合成和处理的试剂类，它可以在耐受不同功能的温和反应条件下，完成 HCl 和 HBr 跨几个烯烃类的受控和选择性马尔可夫尼科夫加成。该过程在实验室规模上特别有价值，并提供了与其他方法的直接比较。
• Iron(II) catalyzed reductive radical cyclization reactions of bromoacetals in the presence of NaBH4: optimization studies and mechanistic insights
  作者：Sara H. Kyne、Christophe Lévêque、Shiwen Zheng、Louis Fensterbank、Anny Jutand、Cyril Ollivier

  DOI：10.1016/j.tet.2016.08.039

  日期：2016.12

  5-Exo-trig radical reductive cyclization reactions of bromoacetals are catalyzed by iron in the presence of the reducing agent NaBH4. Both iron(II) and iron(III) were found to effectively mediate these reactions. As shown by cyclic voltammetry, iron(III) can be reduced to an iron(II) precatalyst before passing through an identical reaction mechanism in which monoelectronic activation of the substrate

  在还原剂NaBH 4的存在下，铁催化了溴乙缩醛的5- Exo- trig自由基还原环化反应。发现铁（II）和铁（III）均可有效介导这些反应。如循环伏安法所示，在通过相同的反应机理之前，铁（III）可以还原为铁（II）预催化剂，在该反应机理中，阴离子氢化铁（I）络合物会发生底物的单电子活化。进一步的研究已经确定，底物（碘衍生物与溴衍生物）和预催化混合物均对确定反应结果具有决定性作用。