泽兰苦素 | 6856-01-5

• 物质功能分类: 天然产物 - 倍半萜
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 泽兰苦素
• 英文名称: Eupatoriopicrin
• 英文别名: [(3aR,4R,6E,10E,11aR)-6,10-dimethyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-(hydroxymethyl)but-2-enoate
• CAS: 6856-01-5
• 化学式: C₂₀H₂₆O₆
• 分子量: 362.4
• InChiKey: VWJYWGYJIDQUEG-DKDOXNMLSA-N

物化性质

• 沸点：
  414.03°C (rough estimate)
• 密度：
  1.1481 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• ISOPRENOIDS AND METHODS OF MAKING THEREOF
  申请人：NORTH CAROLINA STATE UNIVERSITY

  公开号：US20220162188A1

  公开（公告）日：2022-05-26

  Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.

  本发明公开了制备异戊二烯基亚基的方法，以及利用这些异戊二烯基亚基合成异戊二烯类化合物的方法。还提供了使用本发明所述方法制备的异戊二烯类化合物。
• Hetero-substituted cyclic lactone analogues and uses thereof
  申请人：BioVentures, LLC

  公开号：US11021488B2

  公开（公告）日：2021-06-01

  The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.

  本公开提供了包含邻近内酯环的极性取代基的 SL 和 SL 衍生物。此外，本公开还提供了使用 SL 和 SL 衍生物抑制白血病癌细胞生长的方法。
• HETERO-SUBSTITUTED CYCLIC LACTONE ANALOGUES AND USES THEREOF
  申请人：BioVentures, LLC

  公开号：US20180319815A1

  公开（公告）日：2018-11-08

  The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
• [EN] HETERO-SUBSTITUTED CYCLIC LACTONE ANALOGUES AND USES THEREOF<br/>[FR] ANALOGUES DE LACTONE CYCLIQUES À SUBSTITUTION HÉTÉRO ET UTILISATIONS ASSOCIÉS
  申请人：UNIV ARKANSAS

  公开号：WO2017079429A1

  公开（公告）日：2017-05-11

  The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
• [EN] ISOPRENOIDS AND METHODS OF MAKING THEREOF<br/>[FR] ISOPRÉNOÏDES ET LEURS PROCÉDÉS DE FABRICATION
  申请人：UNIV NORTH CAROLINA STATE

  公开号：WO2020150340A1

  公开（公告）日：2020-07-23

  Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.