灵芝醛A | 104700-98-3

• 物质功能分类: 天然产物 - 萜类
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 灵芝醛A
• 英文名称: ganoderal A
• 英文别名: (E,6R)-2-methyl-6-[(5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]hept-2-enal
• CAS: 104700-98-3
• 化学式: C₃₀H₄₄O₂
• 分子量: 436.7
• InChiKey: RHNFCIPJKSUUES-SPFFTVLFSA-N

物化性质

• 熔点：
  127-128℃
• 沸点：
  551.0±50.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)
• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

制备方法与用途

生物活性方面， Ganoderma A 是一种存在于灵芝中的氧化甾醇，能够抑制胆固醇的合成。

文献信息

• PROCESS FOR PREPARING DELTA-7,9(11) STEROIDS FROM GANODERMA LUCIDUM AND ANALOGS THEREOF
  申请人：Minto Robert

  公开号：US20130184244A1

  公开（公告）日：2013-07-18

  Processes for preparing lanostane triterpenes from the medicinal mushroom Ganoderma lucidum , and related compounds are described. Compounds, compositions, and methods for treating cancer are also described.

  本文介绍了从药用蘑菇灵芝中制备鲨烯三萜类化合物的过程，以及相关化合物。同时，还介绍了用于治疗癌症的化合物、组合物和方法。
• Agent hypocholestérolémiant
  申请人：SOCIETE DES PRODUITS NESTLE S.A.

  公开号：EP1228765A1

  公开（公告）日：2002-08-07

  La présente invention concerne un agent hypocholestérolémiant riche en dérivés naturels de lanostérol oxygénés issus de champignons comestibles. Un tel agent peut être additionné à des produits alimentaires. Procédé de fabrication d'un tel agent.

  本发明涉及一种富含从食用真菌中提取的天然含氧羊毛甾醇衍生物的降胆固醇剂。这种制剂可添加到食品中。 一种制造这种药剂的方法。
• Method for extracting oleaginous substances from ganoderma lucidum spores
  申请人：Liu, Xin

  公开号：EP1245235A2

  公开（公告）日：2002-10-02

  The present invention relates to a method for extracting the oleaginous substances from sporoderm-broken Ganoderma spores using SCF-CO2. The method contains the steps of breaking the Ganoderma spores by a mechanical means to obtain the sporoderm-broken spores; and extracting the oleaginous substances from the sporoderm-broken spores using a supercritical fluid - carbon dioxide (SCF-CO2) extraction method. Before breaking the spores by a mechanical means, there may be steps of inducing germination of Ganoderma spores by incubating the spores in a nutritional solution and activating the Ganoderma spores by placing the germination-induced spores in a well ventilated culture box kept at constant temperature and humidity to obtain the sporoderm-broken spores. As for SCF-CO2, the preferred supercritical conditions include 5 M to 60 M Pa of pressure; 32°C to 85°C of temperature; and 5 kg/h to 80 kg/h of flow capacity rate. The total extraction time in SCF-CO2 is between 0.5 hour to 6 hour. The method produces approximately 37% by weight of oleaginous substances from the sporoderm-broken Ganoderma spores. These oleaginous substances are transparent and contain the special fragrance of Ganoderma spores. There is no trace of deposit, solvent residue, or oxidization in the oleaginous substances.

  本发明涉及一种利用 SCF-CO2 从孢子皮破碎的灵芝孢子中提取含油物质的方法。该方法包括以下步骤：用机械方法破碎灵芝孢子，获得孢子破壁孢子；用超临界流体-二氧化碳（SCF-CO2）萃取法从孢子破壁孢子中提取含油物质。在用机械方法破碎孢子之前，可以有以下步骤：将孢子放在营养液中培养，诱导灵芝孢子发芽；将诱导发芽的孢子放在通风良好、恒温恒湿的培养箱中，激活灵芝孢子，以获得孢子皮破碎的孢子。至于 SCF-CO2，首选的超临界条件包括：压力 5 兆帕至 60 兆帕；温度 32 摄氏度至 85 摄氏度；流速 5 千克/小时至 80 千克/小时。在 SCF-CO2 中的总萃取时间为 0.5 小时至 6 小时。按重量计，该方法可从孢子皮破损的灵芝孢子中提取约 37% 的含油物质。这些油状物质是透明的，含有灵芝孢子的特殊香味。油状物质中没有沉淀物、溶剂残留物或氧化物的痕迹。
• METHOD FOR EXTRACTING OLEAGINOUS SUBSTANCES FROM GERMINATION-ACTIVATED GANODERMA LUCIDUM SPORES
  申请人：——

  公开号：US20020131977A1

  公开（公告）日：2002-09-19

  The present invention relates to a method for extracting the oleaginous substances from sporoderm-broken Ganoderma spores using SCF—CO 2 . The method contains the steps of: (1) inducing germination of Ganoderma spores by incubating the spores in a nutritional solution; (2) activating the Ganoderma spores by placing the germination-induced spores in a well ventilated culture box kept at constant temperature and humidity; (3) breaking the Ganoderma spores by a mechanical means to obtain the sporoderm-broken spores; and (4) extracting the oleaginous substances from the sporoderm-broken spores using a supercritical fluid—carbon dioxide (SCF—CO 2 ) extraction method. The preferred supercritical conditions include 5 M to 60 M Pa of pressure; 32° C. to 85° C. of temperature; and 5 kg/h to 80 kg/h of flow capacity rate. The total extraction time in SCF—CO 2 is between 0.5 hour to 6 hour. The method produces approximately 37% by weight of oleaginous substances from the sporoderm-broken Ganoderma spores. These oleaginous substances are transparent and contain the special fragrance of Ganoderma spores. There is no trace of deposit, solvent residue, or oxidization in the oleaginous substances.

  本发明涉及一种利用 SCF-CO 2 .该方法包括以下步骤(1) 将灵芝孢子置于营养液中培养，诱导灵芝孢子萌发； (2) 将诱导萌发的灵芝孢子置于通风良好的恒温恒湿培养箱中，激活灵芝孢子；(3) 用机械方法破碎灵芝孢子，获得孢子体破碎孢子；以及 (4) 用超临界流体-二氧化碳（SCF-CO 2 萃取法。优选的超临界条件包括：压力 5 兆帕至 60 兆帕；温度 32 摄氏度至 85 摄氏度；流速 5 千克/小时至 80 千克/小时。在 SCF-CO 2 中的总萃取时间为 0.5 小时至 6 小时。按重量计，该方法可从孢子皮破损的灵芝孢子中提取约 37% 的含油物质。这些油状物质是透明的，含有灵芝孢子的特殊香味。油状物质中没有沉淀物、溶剂残留物或氧化物的痕迹。
• External preparation for skin containing oleaginous substances extracted from Ganoderma lucidum and method of using the same
  申请人：Chung Chee-Keung

  公开号：US20050180988A1

  公开（公告）日：2005-08-18

  The present invention provides an external preparation for skin which contains, as a major ingredient, oleaginous substances extracted from sporoderm-broken spores from Ganoderma lucidum . The spores are preferably being treated with germination activation. The oleaginous substances are preferred to be extracted by a supercritical fluid-carbon dioxide (SCF-CO 2 ) method. The oleaginous substances prepared by SCF-CO 2 is transparent and odorless. They also demonstrates effects on skin smoothening, wrinkles reduction, aging defiance, inflammation lessening, pigmentation lightening, and irritation alleviation. The external preparation can be a cosmetic or a therapeutic composition.

  本发明提供了一种皮肤外用制剂，其主要成分含有从灵芝孢子-破壁孢子中提取的含油物质。 灵芝 .这些孢子最好经过发芽活化处理。油脂类物质最好通过超临界流体-二氧化碳（SCF-CO 2 )的方法提取。用 SCF-CO 2 制备的油脂类物质透明无味。它们还具有平滑皮肤、减少皱纹、抗衰老、减轻炎症、淡化色斑和减轻刺激的功效。外用制剂可以是化妆品，也可以是治疗组合物。