12-chlorododecanol | 51309-14-9

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物 - 无环醇
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 12-chlorododecanol
• 英文别名: 12-chloro-dodecan-1-ol；12-Chlor-dodecan-1-ol；12-Chlor-dodecylalkohol；12-Chlorododecan-1-ol
• CAS: 51309-14-9
• 化学式: C₁₂H₂₅ClO
• 分子量: 220.783
• InChiKey: MJBHDNOMDYYFEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2905590090

反应信息

• 作为反应物：
  描述：

  12-chlorododecanol 在 盐酸 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 4-(十二烷氧基)苯胺盐酸盐
  参考文献：
  名称：

  Griffin, A. C.; Vaidya, S. R., Molecular Crystals and Liquid Crystals (1969-1991), 1989, vol. 173, p. 85 - 88

  摘要：

  DOI：
• 作为产物：
  描述：

  12-羟基十二酸 在 吡啶 、 氢氧化钾 、 氯化亚砜 、 dimethyl sulfide borane 、 四丁基氯化铵 作用下， 以 乙醚 为溶剂， 生成 12-chlorododecanol
  参考文献：
  名称：

  Bidd, Ilesh; Holdup, David W.; Whiting, Mark C., Journal of the Chemical Society. Perkin transactions I, 1987, p. 2455 - 2464

  摘要：

  DOI：

文献信息

• CONTACT-KILLING, QAC FUNCTIONALIZED THERMOPLASTIC POLYURETHANE FOR CATHETER APPLICATIONS
  申请人：THE UNIVERSITY OF AKRON

  公开号：US20190106525A1

  公开（公告）日：2019-04-11

  In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.

  在各种实施方式中，本发明提供了一种功能化的热塑性聚氨酯（TPU），其中包含大量引入或表面接枝的季铵化合物（QAC），用于接触杀灭多种微生物，其中QAC位于TPU表面，以提供一种无菌表面材料，防止通常涉及设备相关感染（DAIs）的细菌繁殖。本发明的功能化TPU可以形成多种三维形状，例如导管、医疗管、喉部或气管支架、缝合线、假体、伤口敷料和/或医疗设备的涂层，并包含含有二醇单体或烯功能二醇单体的QAC残留物，这使得TPU可以用含有二硫键或自由巯基化合物的QAC进行功能化，以形成具有用于医疗设备的抗菌性能的季铵功能化热塑性聚氨酯化合物。
• Macrocyclic oxalactones ( dioxacycloalkan-ones ) and their use as perfumes
  申请人：PFW AROMA CHEMICALS B.V.

  公开号：EP1099698A1

  公开（公告）日：2001-05-16

  The invention relates to a novel class of macrocyclic oxalactones which are highly useful for use as perfumes. The compounds according to the invention have a very desirable fresh and floral musk odor in combination with other advantageous properties, such as stability, and substantivity.

  该发明涉及一种新型的大环羧酸内酯类化合物，非常适用于作为香水使用。根据该发明的化合物具有非常理想的清新花香麝香气味，结合其他有利特性，如稳定性和持久性。
• [EN] ANTIMICROBIAL AGENT, COATING FORMULATION, COMPOSITE SURFACE COATING AND METHODS OF PREPARING THE SAME<br/>[FR] AGENT ANTIMICROBIEN, FORMULATION DE REVÊTEMENT, REVÊTEMENT DE SURFACE COMPOSITE ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2021107870A1

  公开（公告）日：2021-06-03

  There is provided an antimicrobial agent comprising at least one polymer comprising an optionally substituted heteroaryl amine salt moiety such as an imidazolium salt or an optionally substituted quaternary ammonium cation moiety. The polymer has terminal hydroxyl groups. A coating formulation comprising at least one sol-gel precursor and said antimicrobial agent, as well as a composite surface coating comprising said antimicrobial agent are also provided. Further provided are methods of preparing the antimicrobial agent, composite surface coating and use of the composite surface coating for antimicrobial applications.

  提供一种抗微生物剂，包括至少一种聚合物，其中该聚合物包含一个可选择取代的杂环胺盐基团，例如咪唑盐或可选择取代的季铵阳离子基团。该聚合物具有末端羟基。还提供一种包含至少一种溶胶-凝胶前体和该抗微生物剂的涂层配方，以及包含该抗微生物剂的复合表面涂层。还提供了制备抗微生物剂、复合表面涂层以及使用该复合表面涂层进行抗微生物应用的方法。
• A versatile process for the syntheses of very long chain alkanes, functionalised derivatives and some branched chain hydrocarbons
  作者：Gerald M. Brooke、Simon Burnett、Shahid Mohammed、David Proctor、Mark C. Whiting

  DOI：10.1039/p19960001635

  日期：——

  An earlier method for synthesising very long straight-chain alkanes of very specific lengths has been improved to give, in some cases, gram amounts of materials. Eleven compounds have been made: C98H198, C122H246, C162H326, C194H390, C198H398, C210H422, C242H486, C246H494, C258H518, C294H590 and C390H782. The self-condensation reaction of one of the intermediate aldehydes enabled two chain-branched hydrocarbons to be obtained: C96H193CHRC94H189 where R = CH3 and CH3(CH2)3. Three long-chain compounds containing carboxylic acid groups have been prepared: CH3(CH2)190CO2H,HO2C(CH2)48CO2H and HO2C(CH2)192CO2H.

  一种早期合成特定长度的长直链烷烃的方法已得到改进，在某些情况下可以得到克量的材料。已制备十一种化合物：C98H198、C122H246、C162H326、C194H390、C198H398、C210H422、C242H486、C246H494、C258H518、C294H590和C390H782。其中一种中间体醛的自缩合反应能够得到两种链支化烃：C96H193CHRC94H189，其中R = CH3和 (CH2)3。制备了三种含羧酸基团的长链化合物： ( )190CO2H、HO2C( )48CO2H和HO2C( )192CO2H。
• Highly birefringent liquid-crystalline polymers for photonic applications: synthesis of liquid-crystalline polymers with side-chain azo-tolane mesogens and their holographic properties
  作者：Kunihiko Okano、Atsushi Shishido、Osamu Tsutsumi、Takeshi Shiono、Tomiki Ikeda

  DOI：10.1039/b506131h

  日期：——

  We have synthesized highly birefringent liquid-crystalline polymers (LCPs) containing an azobenzene group directly connected to a tolane moiety (P3ATm), in which the alkyl spacer length (CH2)m was varied as m = 6, 9 and 12. All LCPs showed a nematic phase in a broad temperature range (>170 °C). The homogeneously aligned LCP films showed a high value of birefringence (about 0.4) and a large change in the birefringence could be induced by photoinduced alignment change. Grating formation of LCPs has been explored in a glassy state. The diffraction efficiency (η) showed a maximum when an order–disorder change was completed in the bright areas of the interference patterns. Studies on the effects of light intensity on the grating formation suggested that the diffraction efficiency was high (η = 20%) even though the alignment change of the azo-tolane moieties was small. Furthermore, the behavior of the grating formation was found to be dependent on the alkyl spacer length of P3ATm.

  我们合成了高双折射液晶聚合物 (LCP)，其中含有一个直接连接到甲苯分子的偶氮苯基 (P3ATm)，烷基间隔长度 (CH2)m 变化为 m = 6、9 和 12。所有 LCP 在较宽的温度范围内（>170 °C）都呈现出向列相。均匀配向的 LCP 薄膜显示出较高的双折射值（约 0.4），光诱导配向变化可引起双折射的大幅变化。在玻璃态中探索了 LCP 的光栅形成。当干涉图案的亮区完成有序-无序变化时，衍射效率（η）达到最大值。对光强对光栅形成影响的研究表明，即使偶氮-甲苯分子的排列变化很小，衍射效率也很高（η = 20%）。此外，研究还发现光栅形成的行为取决于 P3ATm 的烷基间隔长度。