isopimaric acid | 514-08-9

• 物质功能分类: 天然产物 - 萜类
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: isopimaric acid
• 英文别名: Isopimarsaeure；7,15-Isopimaradien-18-oic acid; Isopimaric acid A; Delta7,15-Isopimaric acid；(1R,4aR,7S)-7-ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,8,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid
• CAS: 514-08-9；5835-26-7；19941-42-5；30951-15-6；94450-35-8；115333-97-6；141474-11-5
• 化学式: C₂₀H₃₀O₂
• 分子量: 302.457
• InChiKey: MXYATHGRPJZBNA-SSYYCLFMSA-N

物化性质

• 熔点：
  160°
• 比旋光度：
  D16 -3.6° (10.4% soln in 1:1 alcohol:chloroform)
• 沸点：
  383.47°C (rough estimate)
• 密度：
  1.0434 (rough estimate)
• 溶解度：
  二甲基亚砜：~26 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

制备方法与用途

生物活性方面，isopimaric acid 是一种有效的大型钙激活钾通道（大电导钙激活钾通道，简称 BK 通道）的开放剂。

反应信息

• 作为反应物：
  描述：

  isopimaric acid 在 草酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.33h， 生成 Methyl isopimarate
  参考文献：
  名称：

  一种7-羰基-8,15-异海松酸甲酯的制备方法

  摘要：

  本发明公开了一种7‑羰基‑8,15‑异海松酸甲酯的制备方法，具体方法为：将异海松酸甲酯溶于溶剂中配成溶液，用湿膜制备器在马口铁片上涂成均匀的液膜，以马口铁片为反应器，在紫外光照射下进行光催化空气氧化反应。用溶剂淋洗反应后的涂层，将得到的淋洗液蒸除溶剂得到氧化产物。氧化产物用溶剂溶解后，采用制备型薄层色谱分离和纯化后即得产品7‑羰基‑8,15‑异海松酸甲酯，经GC检验其纯度为98.5％。该制备方法操作简单，原料来源广泛，环境污染少，产品纯度高。

  公开号：

  CN104774146B

文献信息

• LABDANE DITERPENOID COMPOUNDS, SEMEN BIOTAE EXTRACT, AND PREPARATION METHOD AND USE THEREOF
  申请人：Sun Yat-Sen University

  公开号：EP2857391A1

  公开（公告）日：2015-04-08

  Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the present invention is a semen biotae extract comprising one or more labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases.

  本发明提供了各种唇形二萜化合物及其衍生物，用于制备预防或治疗神经退行性疾病的药物组合物。本发明还提供了一种精液生物提取物，其中包含一种或多种唇形二萜化合物及其衍生物，用于制备预防或治疗神经退行性疾病的药物组合物。
• PIGMENT DISPERSION AND PRODUCING METHOD THEREOF
  申请人：FUJIFILM Corporation

  公开号：EP3075787A1

  公开（公告）日：2016-10-05

  The present invention provides a pigment dispersion and a method of producing the pigment dispersion. The pigment dispersion includes: water; a pigment; a pigment dispersing polymer; and a rosin acid that includes at least one selected from the group consisting of abietic acid, salts of abietic acid, dihydroabietic acid and salts of dihydroabietic acid, and a total content of abietic acid, salts of abietic acid, dihydroabietic acid and salts of dihydroabietic acid is 50% by mass or higher with respect to a total mass of the rosin acid contained in the pigment dispersion. The pigment dispersion is excellent in terms of dispersibility, storage stability after dispersion, and jetability when used for an inkjet recording ink.

  本发明提供了一种颜料分散体和一种生产颜料分散体的方法。颜料分散体包括：水；颜料；颜料分散聚合物；以及松香酸，其中松香酸包括至少一种选自阿比特酸、阿比特酸的盐类、二氢松香酸和二氢松香酸的盐类，且阿比特酸、阿比特酸的盐类、二氢松香酸和二氢松香酸的盐类的总含量占颜料分散体所含松香酸总质量的 50%或更高。该颜料分散体在分散性、分散后的储存稳定性以及用于喷墨记录墨水时的喷射性方面都非常出色。
• Pigment dispersion and producing method thereof
  申请人：FUJIFILM CORPORATION

  公开号：US10280329B2

  公开（公告）日：2019-05-07

  The present invention provides a pigment dispersion and a method of producing the pigment dispersion. The pigment dispersion includes: water; a pigment; a pigment dispersing polymer; and a rosin acid that includes at least one selected from the group consisting of abietic acid, salts of abietic acid, dihydroabietic acid and salts of dihydroabietic acid, and a total content of abietic acid, salts of abietic acid, dihydroabietic acid and salts of dihydroabietic acid is 50% by mass or higher with respect to a total mass of the rosin acid contained in the pigment dispersion. The pigment dispersion is excellent in terms of dispersibility, storage stability after dispersion, and jettability when used for an inkjet recording ink.

  本发明提供了一种颜料分散体和一种生产颜料分散体的方法。颜料分散体包括：水；颜料；颜料分散聚合物；以及松香酸，松香酸至少包括选自阿比特酸、阿比特酸的盐类、二氢松香酸和二氢松香酸的盐类中的一种，且阿比特酸、阿比特酸的盐类、二氢松香酸和二氢松香酸的盐类的总含量占颜料分散体所含松香酸总质量的 50%或更高。该颜料分散体在用于喷墨记录墨水时，在分散性、分散后的储存稳定性和可润湿性方面都非常出色。
• Novel abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
  申请人：Jeong Tae-Sook

  公开号：US20070190192A1

  公开（公告）日：2007-08-16

  The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.
• NOVEL ABIETANE DITERPENOID COMPOUND, AND COMPOSITION COMPRISING EXTRACT OF TORREYA NUCIFERA, OR ABIETANE DITERPENOID COMPOUNDS OR TERPENOID COMPOUNDS ISOLATED FROM THEM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
  申请人：Jeong Tae-Sook

  公开号：US20080299238A1

  公开（公告）日：2008-12-04

  The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.