4-乙酰氧基-3-甲氧基肉桂酸 | 2596-47-6

• 物质功能分类: 香精与香料 - 合成香料 - 芳香肉桂酸、酯及衍生物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 中文名称: 4-乙酰氧基-3-甲氧基肉桂酸
• 英文名称: 3-(4-acetoxy-3-methoxyphenyl)prop-2-enoic acid
• 英文别名: 3-(4-acetoxy-3-methoxyphenyl)acrylic acid；acetylferulic acid；4-O-acetylferulic acid；3-methoxy-4-acetoxycinnamic acid；Acetylferulasaeure；4-Acetoxy-3-methoxy-cinnamic acid；3-(4-acetyloxy-3-methoxyphenyl)prop-2-enoic acid
• CAS: 2596-47-6
• 化学式: C₁₂H₁₂O₅
• 分子量: 236.224
• InChiKey: IHKNVZISLLDMOR-UHFFFAOYSA-N

物化性质

• 熔点：
  193-196°C
• 沸点：
  372℃
• 密度：
  1.265
• 闪点：
  142℃
• 稳定性/保质期：

  如果按照规格正确使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• TSCA：
  Yes
• 危险等级：
  IRRITANT
• 危险品标志：
  Xi,T
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 包装等级：
  III
• 危险类别：
  6.1
• 危险品运输编号：
  2811
• 储存条件：
  密封在阴凉干燥的环境中。

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : 4-Acetoxy-3-methoxycinnamic acid
CAS-No. : 2596-47-6
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Oral (Category 4)
Eye irritation (Category 2)
Respiratory sensitization (Category 1)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Harmful if swallowed. Irritating to eyes. May cause sensitization by skin contact.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Danger
Hazard statement(s)
H302 Harmful if swallowed.
H319 Causes serious eye irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary statement(s)
P261 Avoid breathing dust.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER or doctor/
physician.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R22 Harmful if swallowed.
R36 Irritating to eyes.
R43 May cause sensitization by skin contact.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36/37 Wear suitable protective clothing and gloves.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C12H12O5
Molecular Weight : 236,22 g/mol
Component Concentration
4-Acetoxy-3-methoxycinnamic acid
CAS-No. 2596-47-6 -

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- log Pow: 1,934
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
May cause sensitization by inhalation.
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion Harmful if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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SECTION 15 - REGULATORY INFORMATION
N/A

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-乙酰氧基-3-甲氧基肉桂酸 在 sodium hydroxide 、 sodium amalgam 、 水 作用下， 生成 3-(4-羟基-3-甲氧基苯基)丙酸
  参考文献：
  名称：

  Tiemann; Nagai, Chemische Berichte, 1878, vol. 11, p. 656

  摘要：

  DOI：
• 作为产物：
  描述：

  阿魏酸乙酯 在 三乙胺 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 4-乙酰氧基-3-甲氧基肉桂酸
  参考文献：
  名称：

  Synthesis of Some Phenylpropanoid Glycosides (PPGs) and Their Acetylcholinesterase/Xanthine Oxidase Inhibitory Activities

  摘要：

  在这项研究中，设计和合成了三类苯丙素糖苷（PPGs），以从红景天中分离的PPGs作为先导化合物。同时测试了它们对乙酰胆碱酯酶（AChE）和黄嘌呤氧化酶（XOD）的抑制能力。部分合成PPGs表现出了优异的酶抑制能力。

  DOI：

  10.3390/molecules16053580

文献信息

• Design, synthesis, and bioassay of 4-thiazolinone derivatives as influenza neuraminidase inhibitors
  作者：Mengwu Xiao、Lvjie Xu、Ding Lin、Wenwen Lian、Manying Cui、Meng Zhang、Xiaowei Yan、Shuishi Li、Jun Zhao、Jiao Ye、Ailin Liu、Aixi Hu

  DOI：10.1016/j.ejmech.2021.113161

  日期：2021.3

  A series of 4-thiazolinone derivatives (D1-D58) were designed and synthesized. All of the derivatives were evaluated in vitro for neuraminidase (NA) inhibitory activities against influenza virus A (H1N1), and the inhibitory activities of the five most potent compounds were further evaluated on NA from two different influenza viral subtypes (H3N2 and B), and then their in vitro anti-viral activities

  设计并合成了一系列4-噻唑啉酮衍生物（D1-D58）。在体外评估了所有衍生物对甲型流感病毒（H1N1）的神经氨酸酶（NA）抑制活性，并进一步评估了来自两种不同流感病毒亚型（H3N2和B）的五种最有效化合物对NA的抑制活性，然后使用细胞病变效应（CPE）降低法评估其体外抗病毒活性。结果表明，大多数目标化合物均显示出中等至良好的NA抑制活性。化合物D18对IC 50的抑制作用最强H1N1流感亚型的抗药性值为13.06μM。中所选择的化合物，D18和D41被证明是针对流感病毒 亚型的最有效的抑制剂（IC 50 = 15.00μM和IC 50 = 14.97μM，分别地）。D25是对抗B型流感最有效的化合物（IC 50 = 16.09μM）。此外，在细胞测定中，D41对N1-H275Y变体显示出比参考化合物Oseltamivir和Amantadine低的毒性和更高的效力。结构-活性关系（SAR）分析表明，引入4-CO
• Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity
  作者：Hai-Xia Ge、Jian Zhang、Ling Chen、Jun-Ping Kou、Bo-Yang Yu

  DOI：10.1016/j.bmc.2012.11.002

  日期：2013.1

  13273, whereas compounds 4a, 4b, 5h, and 5i were microbial glycosylation products by Gliocladium deliquescens NRRL1086. The bioassay results showed that compounds 3 (tetrahydroberberine), 10 (tetrahydroberberrubine), and 5f (cinnamyl ester of 5) and 5i (glycosidic product of 5), exhibited the most potential effects, with IC50 values of 8.35, 6.75, 3.75, and 8.79 nM, respectively. The preliminary structure

  为了发现对组织因子促凝活性的新抑制剂，在脂多糖刺激的人THP-1细胞模型上筛选了21种四氢小ber碱。化合物：在这些四氢原小檗碱，几个独特的化合物是通过微生物转化合成6（升-corydalmine）通过区域选择性脱甲基化，得到灰色链霉菌ATCC 13273，而化合物4A，4B，5H和5I由分别微生物糖基化产物粘帚deliquescens NRRL1086。生物测定结果表明，化合物3（四氢小ber碱），10（四氢小rub碱）和5f（5的肉桂酸酯）和5i（5的糖苷产物）表现出最大的潜在作用，IC 50值分别为8.35、6.75、3.75和8.79 nM。初步的结构和活性关系分析表明，A环的2，3-亚甲基二氧基是强抑制作用所必需的，手性中心C-14的R构型比S型产物具有更高的活性。化合物5的脂肪酸或芳香酸酯的形成，除了肉桂酸酯，将削弱其作用。还有趣的是注意到四氢小ber碱的糖基化将保持甚至增强抑
• Cu(II)-Mediated Decarboxylative Trifluoromethylthiolation of α,β-Unsaturated Carboxylic Acids
  作者：Zhi-Fei Cheng、Ting-Ting Tao、Yi-Si Feng、Wei-Ke Tang、Jun Xu、Jian-Jun Dai、Hua-Jian Xu

  DOI：10.1021/acs.joc.7b02232

  日期：2018.1.5

  A tunable method for the direct trifluoromethylthiolation of α,β-unsaturated carboxylic acids was developed to afford trifluoromethylthiolated ketones or alkenes. The reaction proceeds smoothly under mild conditions and shows an excellent functional group tolerance.

  已开发出一种直接对α，β-不饱和羧酸进行三氟甲基硫醇化的可调谐方法，以提供三氟甲基硫醇化的酮或烯烃。该反应在温和条件下平稳进行，并显示出优异的官能团耐受性。
• Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases
  作者：Aamer Saeed、Parvez Ali Mahesar、Sumera Zaib、Muhammad Siraj Khan、Abdul Matin、Mohammad Shahid、Jamshed Iqbal

  DOI：10.1016/j.ejmech.2014.03.015

  日期：2014.5

  The present study reports the synthesis of cinnamide derivatives and their biological activity as inhibitors of both cholinesterases and anticancer agents. Controlled inhibition of brain acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) may slow neurodegeneration in Alzheimer's diseases (AD). The anticholinesterase activity of phenylcinnamide derivatives was determined against Electric Eel

  本研究报告了肉桂酰胺衍生物的合成及其作为胆碱酯酶和抗癌剂抑制剂的生物活性。对大脑乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）的受控抑制可能会减缓阿尔茨海默氏病（AD）中的神经变性。确定了苯基肉桂酰胺衍生物对Eel乙酰胆碱酯酶（EeAChE）和马血清丁酰胆碱酯酶（hBChE）的抗胆碱酯酶活性，某些化合物似乎是EeAChE和hBChE的中等有效抑制剂。化合物3-（2-（苄氧基）苯基）-N-（3,4,5-三甲氧基苯基）丙烯酰胺（3i）具有IC 50的最大抗EeAChE活性0.29±0.21μM，而3-（2-氯-6-硝基苯基）-N-（3,4,5-三甲氧基苯基）丙烯酰胺（3k）被证明是hBChE最有效的抑制剂，IC 50为1.18± 1.31μM 。为了更好地了解最具活性的化合物对胆碱酯酶的酶-抑制剂相互作用，对高分辨率晶体学结构进行了分子建模研究。还评估了合成化合物对癌细胞系（肺癌）的抗癌作
• Novel Conjugates of Aspirin with Phenolic Acid as Anti-inflammatory Agents Having Significantly Reduced Gastrointestinal Toxicity
  作者：Shan Jiang、Ning Ding、Wei Zhang、Yichun Zhang、Meiyu Geng、Yingxia Li

  DOI：10.1002/ardp.200900217

  日期：2010.3.10

  series of novel conjugates of aspirin with natural phenolic acid antioxidants connected through a diol linker were designed and synthesized as potential bifunctional agents combining antioxidant and anti‐inflammatory activity for reducing gastrointestinal toxicity. In general, the conjugates were found to be efficient antioxidants and many of them demonstrated much more potent anti‐inflammatory activity

  阿司匹林与天然酚酸抗氧化剂通过二醇接头连接的一系列新型偶联物被设计和合成，作为潜在的双功能药物，结合抗氧化和抗炎活性以降低胃肠道毒性。总的来说，这些偶联物被发现是有效的抗氧化剂，其中许多表现出比阿司匹林更有效的抗炎活性。其中，与阿司匹林相比，具有最佳抗炎活性的 5a 和 5b 表现出显着降低的致溃疡效力和毒性。然而，很明显，这些双作用分子的体内抗炎活性与其体外抗氧化能力并不简单一致。