7-triethylsilyl-2-debenzoyl-2-(3,3-dimethylpent-4-enoyl)baccatin | 286932-94-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-triethylsilyl-2-debenzoyl-2-(3,3-dimethylpent-4-enoyl)baccatin
• CAS: 286932-94-3
• 化学式: C₃₇H₅₈O₁₁Si
• 分子量: 706.946
• InChiKey: YYBGIAINJLVKCY-BJCBIALPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.97
• 重原子数：
  49.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  154.89
• 氢给体数：
  2.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  7-triethylsilyl-2-debenzoyl-2-(3,3-dimethylpent-4-enoyl)baccatin 在 吡啶 、 氢氟酸 、 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成 2-debenzoyl-2-(3,3-dimethylpent-4-enoyl)paclitaxel
  参考文献：
  名称：

  Structure–activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells

  摘要：

  A series of new taxoids modified at the C-3', C-3'N, C-10, C-2 and C-7 positions has been designed, synthesized and evaluated for their potency to induce NO and TNF production by peritoneal murine macrophages (Mphi) from LPS-responsive C3H/HeN and LPS-hyporesponsive C3H/HeJ strains and human blood cells, and for their ability to inhibit the growth of Mphi-like cell lines J774.1 and J7.DEF3. The SAR-study has shown that the nature of the substituents at these positions have critical effect on the induction of TNF and NO production by Mphi. Positions G-3' and C-10 are the most flexible and an intriguing effect of the length of the substituents at the C-10 position is observed for taxoids bearing a straight chain alkanoyl moiety. An aromatic group at the C-3'N and C-2 positions is required for the activity, while only hydroxyl or acetyl substituents seem to be tolerated at the C-7 position. The natural stereochemistry in the C-13 isoserine side chain of the taxoids is an absolute requirement for macrophage activation. It has also been clearly shown that there is no correlation between the ability of the taxoids to induce TNF/NO production in C3H/HeN M and the cytotoxicity against Mphi-like cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00181-0
• 作为产物：
  描述：

  10-脱乙酰基巴卡丁 III 在 吡啶 、 咪唑 、 4-二甲氨基吡啶 、 氢氟酸 、 N,N'-二环己基碳二亚胺 、 红铝 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 甲苯 、 乙腈 为溶剂， 反应 24.33h， 生成 7-triethylsilyl-2-debenzoyl-2-(3,3-dimethylpent-4-enoyl)baccatin
  参考文献：
  名称：

  Structure–activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells

  摘要：

  A series of new taxoids modified at the C-3', C-3'N, C-10, C-2 and C-7 positions has been designed, synthesized and evaluated for their potency to induce NO and TNF production by peritoneal murine macrophages (Mphi) from LPS-responsive C3H/HeN and LPS-hyporesponsive C3H/HeJ strains and human blood cells, and for their ability to inhibit the growth of Mphi-like cell lines J774.1 and J7.DEF3. The SAR-study has shown that the nature of the substituents at these positions have critical effect on the induction of TNF and NO production by Mphi. Positions G-3' and C-10 are the most flexible and an intriguing effect of the length of the substituents at the C-10 position is observed for taxoids bearing a straight chain alkanoyl moiety. An aromatic group at the C-3'N and C-2 positions is required for the activity, while only hydroxyl or acetyl substituents seem to be tolerated at the C-7 position. The natural stereochemistry in the C-13 isoserine side chain of the taxoids is an absolute requirement for macrophage activation. It has also been clearly shown that there is no correlation between the ability of the taxoids to induce TNF/NO production in C3H/HeN M and the cytotoxicity against Mphi-like cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00181-0

文献信息

• Macrocycle Formation by Ring-Closing Metathesis. Application to the Syntheses of Novel Macrocyclic Taxoids
  作者：Iwao Ojima、Songnian Lin、Tadashi Inoue、Michael L. Miller、Christopher P. Borella、Xudong Geng、John J. Walsh

  DOI：10.1021/ja000293w

  日期：2000.6.1

  synthesized. The syntheses of these macrocycles 6 and 6‘ were accomplished using the highly efficient ruthenium-catalyzed ring-closing metathesis (RCM) of taxoid-ω,ω‘-dienes 7 in the key step. Taxoid-ω,ω‘-dienes 7 were obtained through the ring-opening coupling of 4-alkenyl-β-lactams 9 with 2-alkenoylbaccatins 8 in good to high yields. Although various novel pentacyclic macrocycles 6 and 6‘ were successfully

  设计并合成了一系列新的大环紫杉类化合物 6 和 6'，带有连接 C-2 和 C-3' 位置的取代基的 16、17 和 18 元环。这些大环 6 和 6' 的合成是在关键步骤中使用紫杉醇-ω,ω'-二烯 7 的高效钌催化闭环复分解 (RCM) 完成的。通过 4-链烯基-β-内酰胺 9 与 2-链烯酰基浆果赤霉素 8 的开环偶联，以良好到高产率获得紫杉素-ω,ω'-二烯 7。尽管成功合成了各种新型五环大环 6 和 6'，但在某些情况下无法进行所需的 RCM。讨论了 RCM 在其应用于高度功能化的复杂基材的范围和限制。发现所有大环紫杉类化合物 6 和 6' 都具有细胞毒性，