Ryanadol | 15662-33-6

• 物质功能分类: 天然产物 - 生物碱
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Ryanadol
• 英文别名: (2,6,9,11,13,14-hexahydroxy-3,7,10-trimethyl-11-propan-2-yl-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadecan-12-yl) 1H-pyrrole-2-carboxylate
• CAS: 15662-33-6
• 化学式: C₂₅H₃₅NO₉
• 分子量: 493.5
• InChiKey: JJSYXNQGLHBRRK-UHFFFAOYSA-N

物化性质

• 比旋光度：
  D25 +26° (methanol)
• 沸点：
  586.95°C (rough estimate)
• 密度：
  1.2805 (rough estimate)
• 溶解度：
  DMSO：可溶10mg/mL，澄清
• 熔点：
  219-220 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  173
• 氢给体数：
  7
• 氢受体数：
  9

安全信息

• 危险品标志：
  Xn,N
• 安全说明：
  S36/37,S60,S61
• 危险类别码：
  R21/22
• 危险品运输编号：
  UN 3077 9
• RTECS号：
  VM4025000

SDS

Name:	Ryanodine Material Safety Data Sheet
Synonym:	Ryanadol; 3-(1 H-pyrrole-2-carboxylate
CAS:	15662-33-6

Section 1 - Chemical Product MSDS Name:Ryanodine Material Safety Data Sheet
Synonym:Ryanadol; 3-(1 H-pyrrole-2-carboxylate

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
15662-33-6	Ryanodine		239-732-2

Hazard Symbols: XN
Risk Phrases: 20/22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
Harmful if swallowed.
Inhalation:
Harmful if inhaled. The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Deep freeze (below -20C).

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 15662-33-6: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 219-220 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: insoluble
Specific Gravity/Density:
Molecular Formula: C25H35NO9
Molecular Weight: 493.2463

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 15662-33-6: VM4025000 LD50/LC50:
CAS# 15662-33-6: Oral, mouse: LD50 = 650 mg/kg; Oral, rabbit: LD50 = 650 mg/kg; Oral, rat: LD50 = 750 mg/kg; Skin, rabbit: LD50 = >4 gm/kg.
Carcinogenicity:
Ryanodine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/22 Harmful by inhalation and if swallowed.
Safety Phrases:
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 15662-33-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 15662-33-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 15662-33-6 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

生物活性

Ryanodine 是一种可渗透细胞的兰尼碱受体调节剂。根据其浓度，Ryanodine 可以刺激或抑制 Ryanodine 介导的 Ca2+ 释放。在 Ryania speciosa 中发现了这种有毒二萜。

靶点

• Ryanodine receptor

体内研究

• Ryanodine (100-5000 nM, 30-120 分钟) 以剂量相关的方式不可逆地抑制快肌和慢肌的单收缩及 tetanic 张力。
• 在浓度超过 250 nM 时，Ryanodine 会诱导一种缓慢发展的、剂量依赖性的收缩，这种收缩无法被 5 mM Co2+ 阻断。

类别

农药

毒性分级

中毒

急性毒性

• 口服 - 大鼠 LD50: 750 毫克/公斤；
• 口服 - 小鼠 LD50: 650 毫克/公斤

可燃性危险特性

燃烧产生有毒氮氧化物气体

储运特性

库房通风、低温干燥；与食品原料分开储运

灭火剂

干粉、泡沫、砂土